eLife

Latest preprint reviews

1. Butyrate rescues chlorpyrifos-induced social deficits through inhibition of class I histone deacetylases

   This article has 14 authors:

   1. Leonardo Diaz
   2. Ally Xinyi Kong
   3. Ping Zhang
   4. Jinhua Chi
   5. Khoa Pham
   6. Maja Johnson
   7. Aiden Eno
   8. Isabelle Douglas
   9. Yuxuan Mao
   10. James W MacDonald
   11. Julia Yue Cui
   12. Theo Bammler
   13. Haiwei Gu
   14. Yijie Geng

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This valuable manuscript demonstrates that embryonic exposure to the pesticide chlorpyrifos (CPF) impairs juvenile zebrafish social behavior and sets out to define the underlying mechanism. The authors provide solid evidence that butyrate and class I histone deacetylases are involved, as their modulation rescues the phenotype. However, claims that CPF acts through the microbiome and nitric oxide signaling remain correlative and incomplete. Additional validation would strengthen the intriguing hypotheses raised by this work.

   Reviewed by eLife

2. Mycobacterium tuberculosis suppresses protective Th17 responses during infection

   This article has 7 authors:

   1. Alex Zilinskas
   2. Amir Balakhmet
   3. Douglas Fox
   4. Heyuan Michael Ni
   5. Carolina Agudelo
   6. Helia Samani
   7. Sarah A Stanley

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study investigates the mechanisms by which Mycobacterium tuberculosis suppresses protective Th17 differentiation during infection. Using ESX-1- and PDIM-deficient mutants of M. tuberculosis, which lack functional eccC1 and fadD28 respectively, the authors demonstrate that these virulence factors actively restrict IL-17 responses via a T-bet-dependent pathway, independent of overall bacterial attenuation or infection duration. While the precise molecular interactions by which ESX-1 and PDIM modulate Th17 differentiation warrant further elucidation, the experiments are rigorously designed, the findings are clearly presented, and the evidence is solid for a specific role for these factors in limiting protective IL-17 immunity in M. tuberculosis infection.

   Reviewed by eLife

3. We couldn't get details of this article at this time:
   10.1101/2025.11.07.687167

4. We couldn't get details of this article at this time:
   10.64898/2026.01.29.702641

5. We couldn't get details of this article at this time:
   10.64898/2026.01.06.697926

6. We couldn't get details of this article at this time:
   10.64898/2026.01.02.697350

7. Neural Mechanisms of Willed Attention Control

   This article has 7 authors:

   1. Changhao Xiong
   2. Qiang Yang
   3. Sungkean Kim
   4. Sreenivasan Meyyappan
   5. Jesse J Bengson
   6. George R Mangun
   7. Mingzhou Ding

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This useful study supplements previous publications of willed attention by addressing a frontoparietal network that supports internal goal generation. The evidence is solid in analyzing two datasets collected at different independent sites, using the same willed-attention paradigm and combining fMRI and EEG. This work will interest cognitive psychologists and neuroscience researchers.

   Reviewed by eLife

8. We couldn't get details of this article at this time:
   10.1101/2025.10.23.25338642

9. We couldn't get details of this article at this time:
   10.1101/2025.03.02.641008

10. We couldn't get details of this article at this time:
    10.1101/2025.06.13.659479