eLife

Latest preprint reviews

1. Small brown planthopper infestation enhances it reproduction and insecticide tolerance by manipulating glucose distribution and levels in rice

   This article has 8 authors:

   1. Hainan Zhang
   2. Qi Zhang
   3. Huichen Ge
   4. Jiaping Wei
   5. Kun Qian
   6. Xiaolong Liu
   7. Hai Li
   8. Jianjun Wang

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study investigates how infestation by the small brown planthopper (Laodelphax striatellus) reshapes rice carbohydrate allocation and demonstrates that host-derived glucose enhances insect fecundity and imidacloprid tolerance, through the activation of conserved nutrient-sensing and endocrine pathways. Across extensive and complementary approaches, including plant manipulations, glucose supplementation, RNAi, pharmacological inhibition, rescue experiments, and biochemical assays, the authors provide strong evidence that glucose activates the TOR-juvenile hormone-vitellogenin axis to promote reproduction and co-regulates GST-mediated detoxification via both TOR-JH signaling and GCL-GSH metabolism. The mechanistic framework is coherent and well supported by hierarchical validation and functional assays. While minor weaknesses exist regarding the generalizability of the findings and the identification of upstream initiating signals, the work provides a compelling framework linking nutrient sensing to pest adaptation.

   Reviewed by eLife

2. ARID5B mutations cause a neurodevelopmental syndrome with neuroinflammation episodes

   This article has 62 authors:

   1. Hendrikus J van Heesbeen
   2. Nazim Rabouhi
   3. Aurélie Gouronc
   4. Angéline Preto
   5. Justine Rousseau
   6. Jade Charbonneau
   7. Antonio Vitobello
   8. Ange-Line Bruel
   9. Anne-Sophie Denommé-Pichon
   10. Estelle Colin
   11. Bertrand Isidor
   12. Sophie Nambot
   13. Desiree DeMille
   14. Pinar Bayrak-Toydemir
   15. Nicola Longo
   16. Boris Keren
   17. Alexandra Afenjar
   18. Jolien S Klein Wassink-Ruiter
   19. Ingrid PC Krapels
   20. Hannah Titheradge
   21. Gavin Ryan
   22. Matias Wagner
   23. Jill A Rosenfeld
   24. David R Witt
   25. Anirudh Saronwala
   26. Yaping Yang
   27. Annick Rein-Rothschild
   28. Ortal Barel
   29. Reena Jethva
   30. Saskia B Wortmann
   31. Katharina Diepold
   32. Kevin Rostasy
   33. Lola K Clarkson
   34. Kathryn T Drazba
   35. Raymond J Louie
   36. Himanshu Goel
   37. Outi Kuismin
   38. Pekka Nokelainen
   39. Jianling Ji
   40. Ashley Mills
   41. Matthew A Deardorff
   42. María Palomares-Bralo
   43. María-Ángeles Gómez-Cano
   44. Alberto Fernández-Jaén
   45. Peter J Hulick
   46. Maureen Jacob
   47. Benjamin Cogne
   48. Kandamurugu Manickam
   49. Xueqi Wang
   50. Gail Graham
   51. Bert Callewaert
   52. Mercedes Zoeteman
   53. Michael L Raff
   54. Marion Aubert Mucca
   55. Médéric Jeanne
   56. Grace Raines
   57. Amy Crunk
   58. Sureni V Mullegama
   59. Taila Hartley
   60. Kristin Kernohan
   61. Kym Boycott
   62. Philippe M Campeau

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This valuable study identifies a novel neurodevelopmental syndrome caused by variants in ARID5B, supported by solid human genetic evidence from a well-characterized cohort. While the clinical data establish a clear genotype-phenotype correlation, the functional evidence regarding the proposed molecular mechanisms remains incomplete. Addressing the gaps in the functional characterization and refining the clinical assertions would significantly strengthen the conclusions.

   Reviewed by eLife

3. Dual Inhibition of MYRF Cleavage by Its JM Region and PAN-1 CCT Gates Developmental Timing in C. elegans

   This article has 9 authors:

   1. Zhimin Xu
   2. Xiaoting Feng
   3. Haochen Lyu
   4. Yong-Hong Yan
   5. Yongqi Zhou
   6. Zhizhi Wang
   7. Fang Bai
   8. Meng-Qiu Dong
   9. Yingchuan B Qi

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study advances our understanding of developmental timing mechanisms by studying the cleavage, nuclear translocation, and oscillation of the transcription factor MYRF-1 (vertebrate MYRF) during C. elegans larval development. The evidence supporting the conclusions is solid, with elegant genome engineering experiments and state-of-the-art microscopy. The work will be of broad interest to cell and developmental biologists.

   Reviewed by eLife

4. Rescuing the Function of Missense-Mutated Tumor Suppressor VHL using Stabilizing Small Molecules

   This article has 16 authors:

   1. Mariam Ahmed Fouad
   2. Christopher S Parry
   3. Sven A Miller
   4. Shipra Malhotra
   5. Glenn A Doyle
   6. Ezra Shimabenga
   7. Mashhura Nurilloeva
   8. Elena Bondarenko
   9. Grigorii V Andrianov
   10. Wayne Childers
   11. Benjamin E Blass
   12. Petr B Makhov
   13. Johnathan R Whetstine
   14. Margie L Clapper
   15. Erica A Golemis
   16. John Karanicolas

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study presents important findings by identifying small molecules that can stabilize and refold missense-mutated VHL tumor suppressor protein, offering a potential therapeutic approach for clear cell renal cell carcinoma. The computational design approach is well-executed, but the evidence is incomplete due to insufficient demonstration that HIF2 downregulation occurs through on-target VHL rescue rather than off-target effects. Additional experiments with appropriate controls are needed to establish the specificity of the mechanism.

   Reviewed by eLife

5. Amino acid homorepeats act as buffers to maintain proteostasis and constrain the compatible sequence space of proteomes

   This article has 7 authors:

   1. Yukihiro Murase
   2. Naoki Kitamura
   3. Shotaro Namba
   4. Ayano Satoh
   5. Takashi Makino
   6. Ayako Moriya
   7. Hisao Moriya

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study analyzed the impact of amino acid homorepeats on protein expression and solubility in yeast and E. coli. The authors provided convincing evidence that hydrophobic and positively charged amino acids are toxic and that counterselection during evolution reduced the occurrence of such proteotoxic protein sequences. This study will be of interest to cell biologists and biochemists, particularly those working on proteostasis.

   Reviewed by eLife

6. We couldn't get details of this article at this time:
   10.1101/2025.10.09.681472

7. Miniscope Processing Suite (MPS): An Intuitive, No-Code, Scalable Pipeline for Long-Duration Calcium Imaging

   This article has 4 authors:

   1. Ari Peden-Asarch
   2. Meredith Weinstock
   3. Kevin R Coffey
   4. John F Neumaier

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This valuable study introduces MPS, an open-source pipeline that addresses a significant technical bottleneck by making miniscope data analysis more accessible. Characterized by speed and a low barrier to entry, the software's performance is supported by solid evidence. This work will be of interest to miniscope users seeking a streamlined, memory-efficient, end-to-end analysis solution.

   Reviewed by eLife

8. We couldn't get details of this article at this time:
   10.1101/2024.10.15.618375

9. We couldn't get details of this article at this time:
   10.1101/2025.02.19.639148

10. A hypothalamo-septo-hippocampal circuit for REM sleep-dependent consolidation of social memory

    This article has 13 authors:

    1. Tingliang Jian
    2. Wenjun Jin
    3. Mengru Liang
    4. Xiang Liao
    5. Kuan Zhang
    6. Shanshan Liang
    7. Chunqing Zhang
    8. Chao He
    9. Hongbo Jia
    10. Yanjiang Wang
    11. Jian Han
    12. Xiaowei Chen
    13. Han Qin

    This article has been curated by 1 group:

    • Curated by eLife

      eLife Assessment

      This study systematically characterizes the activity patterns of a lateral supramammillary nucleus (SuM)-medial septum (MS)-hippocampus circuit across sleep-wake cycles and its role in memory consolidation. This work is fundamental because it identifies a previously unrecognized brain hub that helps coordinate how different types of memory are supported during a specific sleep state, advancing our understanding of how sleep contributes to memory organization. The work is well-designed, and the data are solid, supporting clear and significant conclusions; however, some mechanistic details and causal relationships would benefit from further clarification or additional experiments. The paper provides new insights into how distinct memory modalities could be processed by parallel, sleep-active subcortical-hippocampal circuits, which would be of general interest to a broad neuroscience audience.

    Reviewed by eLife