eLife

Latest preprint reviews

1. We couldn't get details of this article at this time:
   10.1101/2025.11.24.690102

2. Evaluation of antibiotic and peptide vaccine strategies for mirror bacterial infections

   This article has 3 authors:

   1. Alexander Kleinman
   2. Joe Torres
   3. Brian Wang

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study experimentally probes potential antibiotic activity against hypothetical "mirror bacteria" with reversed chirality, showing that D-enantiomers of several approved antibiotics largely lack activity against natural bacteria (as a proxy for mirror organisms) and that conjugated D-peptides can elicit strong binding antibody responses in mice when adjuvanted. The evidence is solid for these core observations but incomplete on issues of chiral purity, functional antibody assays, replicates, and pharmacodynamic readouts; the work also overreaches in extrapolations without deeper mechanistic integration or native-format validation. Overall, the work offers a cautious, relevant contribution to mirror microbiology discussions and will interest infectious disease researchers.

   Reviewed by eLife

3. Anesthesia Lowers Spatial Frequency Preference in the Primary Visual Cortex

   This article has 5 authors:

   1. Jiahao Wu
   2. Taisuke Yoneda
   3. Kallum Robinson
   4. Naotsugu Tsuchiya
   5. Yumiko Yoshimura

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This paper describes useful findings on the effects of isoflurane anesthesia on the visual cortical circuitry of the mouse. It provides solid evidence that the visual spatial frequency sensitivity becomes coarser (lower resolution) during anesthesia, with distinct effects described in excitatory neurons, and parvalbumin (PV) and somatostatin (SOM) positive interneurons. This study should be of interest to neuroscientists studying the mouse visual cortex and the effects of anesthesia on cortical circuitry.

   Reviewed by eLife

4. We couldn't get details of this article at this time:
   10.1101/2024.01.10.574926

5. Structural elucidation of the hexameric MmpS4-MmpL4 complex from Mycobacterium tuberculosis

   This article has 6 authors:

   1. Jennifer C Earp
   2. Nicolas P Lichti
   3. Alisa A Garaeva
   4. Virginia Meikle
   5. Michael Niederweis
   6. Markus A Seeger

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study provides valuable insights through the elucidation of the first full-length structure of the heterohexameric (MmpS4)₃-(MmpL4)₃ transporter complex from Mycobacterium tuberculosis, advancing understanding of its transport mechanism, linked to virulence and drug resistance. The structural analysis is convincing, offering a clear framework for future mechanistic studies. Major strengths include a comprehensive structural characterization of the complex, though some conclusions require further validation.

   Reviewed by eLife

6. White Matter Stratification in Depression Predicts Multidimensional Antidepressant Responses

   This article has 11 authors:

   1. Jiaolong Qin
   2. Xinyi Wang
   3. Huangjing Ni
   4. Ye Wu
   5. Haiyan Liu
   6. Lingling Hua
   7. Rui Yan
   8. Hao Tang
   9. Peng Zhao
   10. Zhijian Yao
   11. Qing Lu

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study presents valuable findings for identifying biotypes of depression patients using white matter measures, which are under-utilised and under-appreciated in current biological and computational psychiatry work. The evidence supporting the claims is solid, although enhanced interpretability of the identified biotypes across both white matter and symptom levels, and better justification of the choice of models would strengthen the paper. Overall, this study will be of interest to the broad community of neuroimagers, clinicians, and biological and computational psychiatry researchers.

   Reviewed by eLife

7. We couldn't get details of this article at this time:
   10.1101/2025.11.23.690026

8. We couldn't get details of this article at this time:
   10.64898/2026.01.24.701544

9. We couldn't get details of this article at this time:
   10.64898/2025.12.29.696817

10. Alternative splicing of PIF4 regulates plant development under heat stress

    This article has 6 authors:

    1. María Niño-González
    2. Benjamin Alary
    3. Dóra Szakonyi
    4. Tom Laloum
    5. Paula Duque
    6. Guiomar Martín

    This article has been curated by 1 group:

    • Curated by eLife

      eLife Assessment

      This manuscript identifies temperature-dependent alternative splicing of PIF4 in Arabidopsis thaliana and shows that heat stress promotes the accumulation of a short exon 5-skipping isoform that is predicted to encode a non-functional protein. This finding is important, and it provides an intriguing new layer of regulation for PIF4; however, the strength of the mechanistic conclusions is limited, and several key conclusions rely on indirect evidence. As a result, while the data robustly demonstrate heat-regulated alternative splicing of PIF4, the causal role of PIF4 isoforms' balance in shaping heat-induced developmental responses remains only partially supported and the strength of the evidence presented is incomplete. This work will be of interest to biologists working on alternative splicing.

    Reviewed by eLife