eLife

Latest preprint reviews

1. A pathogenic human Orai1 mutation unmasks STIM1-independent rapid inactivation of Orai1 channels

   This article has 3 authors:

   1. Priscilla S-W Yeung
   2. Megumi Yamashita
   3. Murali Prakriya

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This manuscript reports novel and important findings on the mechanisms of regulation of CRAC channels. Collectively, the work represents an important conceptual advancement, showing that stromal interaction molecule-1 is not necessary for Ca2+-dependent inactivation of the Orai1 channel and that Orai1 likely contains a Ca2+ sensor for autoregulatio. The experiments are carefully conducted, and the data is of high quality and support the major conclusions of the authors.

   Reviewed by eLife

2. Vernalization-triggered expression of the antisense transcript COOLAIR is mediated by CBF genes

   This article has 9 authors:

   1. Myeongjune Jeon
   2. Goowon Jeong
   3. Yupeng Yang
   4. Xiao Luo
   5. Daesong Jeong
   6. Jinseul Kyung
   7. Youbong Hyun
   8. Yuehui He
   9. Ilha Lee

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important paper advances the understanding, in the model plant Arabidopsis thaliana, of the molecular basis of the promotion of flowering in the spring by exposure to winter cold through a process known as vernalization. In Arabidopsis, there are two classes of long non-coding RNAs produced only when plants are in the cold, and this work provides compelling evidence that the cold-induced expression of one of these (COOLAIR) involves C-repeat binding factor proteins that bind to cognate binding elements in the COOLAIR promoter, but also that COOLAIR is not required for the vernalization-mediated promotion of flowering under standard laboratory conditions in which the vernalization response is measured.

   Reviewed by eLife

3. Proliferative exhausted CD8+ T cells exacerbate long-lasting anti-tumor effects in human papillomavirus-positive head and neck squamous cell carcinoma

   This article has 33 authors:

   1. Danni Cheng
   2. Ke Qiu
   3. Yufang Rao
   4. Minzi Mao
   5. Li Li
   6. Yan Wang
   7. Yao Song
   8. Junren Chen
   9. Xiaowei Yi
   10. Xiuli Shao
   11. Shao Hui Huang
   12. Yi Zhang
   13. Xuemei Chen
   14. Sisi Wu
   15. Shuaishuai Yu
   16. Jun Liu
   17. Haiyang Wang
   18. Xingchen Peng
   19. Daibo Li
   20. Lin Yang
   21. Li Chen
   22. Zhiye Ying
   23. Yongbo Zheng
   24. Meijun Zheng
   25. Binwu Ying
   26. Xiaoxi Zeng
   27. Wei Zhang
   28. Wei Xu
   29. Geoffrey Liu
   30. Fei Chen
   31. Haopeng Yu
   32. Yu Zhao
   33. Jianjun Ren

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study provides fundamental insight into the functional impact of CDK4 inhibition on cells in the tumor microenvironment, which is of high importance and interest to the field. The compelling conclusion that proliferative exhausted T cells are associated with response in HPV+ head and neck cancer is supported by the cohort of 14 patients with paired tumor and adjacent normal tissue and rigorous bioinformatic analysis of nearly 50,000 single CD3+ T cell transcriptomes. This work will be of interest to researchers across tumor types and in other immunological fields of study.

   Reviewed by eLife

4. A unified neural account of contextual and individual differences in altruism

   This article has 3 authors:

   1. Jie Hu
   2. Arkady Konovalov
   3. Christian C Ruff

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This paper will be of considerable interest to researchers studying the psychological and neural basis of variation in prosocial behavior. The authors use a sophisticated combination of computational modeling and EEG to show that variation in generosity produced by changes in context (i.e., disadvantageous vs. advantageous inequality) and variation due to individual differences in concern for others both seem to occur early, during the perceptual or valuation stage of a choice, rather than later on during choice comparison. However, these two sources of variation also appear to operate through distinct mechanisms during this stage of processing, which spurs further questions about the drivers of human prosocial behavior.

   Reviewed by eLife

5. Tomosyn affects dense core vesicle composition but not exocytosis in mammalian neurons

   This article has 7 authors:

   1. Aygul Subkhangulova
   2. Miguel A Gonzalez-Lozano
   3. Alexander JA Groffen
   4. Jan RT van Weering
   5. August B Smit
   6. Ruud F Toonen
   7. Matthijs Verhage

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     The authors examine the function of Tomosyn, in dense core vesicle fusion in neuronal cultures from mice expressing conditional alleles of tomosyn and tomosyn-2. The authors show here that while loss of tomosyns did not affect dense core vesicle exocytosis, it reduced the expression of several key dense core cargos, including BDNF. However, "rescue" experiments are needed to validate the specificity of the effects.

   Reviewed by eLife

6. Cardiac electrophysiological remodeling associated with enhanced arrhythmia susceptibility in a canine model of elite exercise

   This article has 23 authors:

   1. Alexandra Polyák
   2. Leila Topal
   3. Noémi Zombori-Tóth
   4. Noémi Tóth
   5. János Prorok
   6. Zsófia Kohajda
   7. Szilvia Déri
   8. Vivien Demeter-Haludka
   9. Péter Hegyi
   10. Viktória Venglovecz
   11. Gergely Ágoston
   12. Zoltán Husti
   13. Péter Gazdag
   14. Jozefina Szlovák
   15. Tamás Árpádffy-Lovas
   16. Muhammad Naveed
   17. Annamária Sarusi
   18. Norbert Jost
   19. László Virág
   20. Norbert Nagy
   21. István Baczkó
   22. Attila S Farkas
   23. András Varró

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study presents valuable comprehensive data that underpin the enhanced ventricular arrhythmogenesis in elite trained athletes. The study is logistical challenge and the multiscale approaches used is a strength of the study. The data presented are strong and support most of the authors' claims.

   Reviewed by eLife

7. Interplay between external inputs and recurrent dynamics during movement preparation and execution in a network model of motor cortex

   This article has 3 authors:

   1. Ludovica Bachschmid-Romano
   2. Nicholas G Hatsopoulos
   3. Nicolas Brunel

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     The study provides a recurrent network model of M1 for center-out reaches. The "neurons" in the model show uncorrelated tuning for movement direction during preparation and execution with dynamic transition between the two states. The continuous attractor model provides an interesting example of flexible switching between neural representations.

   Reviewed by eLife

8. Antibodies to repeat-containing antigens in Plasmodium falciparum are exposure-dependent and short-lived in children in natural malaria infections

   This article has 14 authors:

   1. Madhura Raghavan
   2. Katrina L Kalantar
   3. Elias Duarte
   4. Noam Teyssier
   5. Saki Takahashi
   6. Andrew F Kung
   7. Jayant V Rajan
   8. John Rek
   9. Kevin KA Tetteh
   10. Chris Drakeley
   11. Isaac Ssewanyana
   12. Isabel Rodriguez-Barraquer
   13. Bryan Greenhouse
   14. Joseph L DeRisi

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study describes the use of a new and valuable tool, namely phage display of Plasmodium falciparum proteome-wide peptides, for profiling of antibody targets. The study, conducted using plasma from Ugandan children and adults, represents an important aspect of naturally acquired antibodies with seroreactive responses to the intra-and inter-protein repeat regions. The results are, however, so far incomplete, and confirmatory data that antibodies to inter-protein repeat motifs do cross-react are needed.

   Reviewed by eLife

9. Specific targeting of inflammatory osteoclastogenesis by the probiotic yeast S. boulardii CNCM I-745 reduces bone loss in osteoporosis

   This article has 21 authors:

   1. Maria-Bernadette Madel
   2. Julia Halper
   3. Lidia Ibáñez
   4. Lozano Claire
   5. Matthieu Rouleau
   6. Antoine Boutin
   7. Adrien Mahler
   8. Rodolphe Pontier-Bres
   9. Thomas Ciucci
   10. Majlinda Topi
   11. Christophe Hue
   12. Jerome Amiaud
   13. Salvador Iborra
   14. David Sancho
   15. Dominique Heymann
   16. Henri-Jean Garchon
   17. Dorota Czerucka
   18. Florence Apparailly
   19. Isabelle Duroux-Richard
   20. Abdelilah Wakkach
   21. Claudine Blin-Wakkach

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     In this work, the authors provide convincing evidence about the existence of two distinct osteoclast populations with specific expression profiles and properties and show that the probiotic yeast S. boulardii may be useful in managing inflammation-mediated bone loss, including estrogen deprivation-mediated osteoporosis. The reported study aims to bring the concept of heterogeneous osteoclasts into a proof-of-principle therapeutic application, which may mean that the use of probiotics might combat osteoporosis towards a better bone quality than current therapies. The molecular mechanism of how the probiotic yeast S. boulardii treatment acts via the receptors remains obscure since it might act via changes in the gut permeability or by components directly released by the fungus.

   Reviewed by eLife

10. Pharmacometrics of high-dose ivermectin in early COVID-19 from an open label, randomized, controlled adaptive platform trial (PLATCOV)

    This article has 38 authors:

    1. William HK Schilling
    2. Podjanee Jittamala
    3. James A Watson
    4. Maneerat Ekkapongpisit
    5. Tanaya Siripoon
    6. Thundon Ngamprasertchai
    7. Viravarn Luvira
    8. Sasithorn Pongwilai
    9. Cintia Cruz
    10. James J Callery
    11. Simon Boyd
    12. Varaporn Kruabkontho
    13. Thatsanun Ngernseng
    14. Jaruwan Tubprasert
    15. Mohammad Yazid Abdad
    16. Nattaporn Piaraksa
    17. Kanokon Suwannasin
    18. Pongtorn Hanboonkunupakarn
    19. Borimas Hanboonkunupakarn
    20. Sakol Sookprome
    21. Kittiyod Poovorawan
    22. Janjira Thaipadungpanit
    23. Stuart Blacksell
    24. Mallika Imwong
    25. Joel Tarning
    26. Walter RJ Taylor
    27. Vasin Chotivanich
    28. Chunlanee Sangketchon
    29. Wiroj Ruksakul
    30. Kesinee Chotivanich
    31. Mauro Martins Teixeira
    32. Sasithon Pukrittayakamee
    33. Arjen M Dondorp
    34. Nicholas PJ Day
    35. Watcharapong Piyaphanee
    36. Weerapong Phumratanaprapin
    37. Nicholas J White
    38. on behalf of the PLATCOV Collaborative Group

    This article has been curated by 1 group:

    • Curated by eLife

      eLife assessment

      This highly important paper uses a Bayesian linear regression approach in a clinical trial to establish that ivermectin does not increase the clearance rate of SARS-CoV-2 relative to no study drug. The strength of evidence is compelling. Particular strengths are that the paper is clearly written, a novel and important adaptive study design, and linear mixed modeling to account for participant heterogeneity. The work will be of interest to clinicians, statisticians, and public health departments.

    Reviewed by eLife