eLife

Latest preprint reviews

1. scRNA-sequencing in chick suggests a probabilistic model for cell fate allocation at the neural plate border

   This article has 7 authors:

   1. Alexandre P Thiery
   2. Ailin Leticia Buzzi
   3. Eva Hamrud
   4. Chris Cheshire
   5. Nicholas M Luscombe
   6. James Briscoe
   7. Andrea Streit

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     The study of Thiery et al. details the heterogeneous expression of a very large number of genes presumably associated with cell fate decisions in the ectoderm at the neural plate border in early avian embryos. The authors mostly succeed in presenting their very complex strategy of data analysis in a clear way but the work is incomplete with some conceptual weaknesses in how the authors describe and interpret their results. By focusing on one of the earliest cell fate decisions in the ectoderm of a vertebrate embryo, this study will be valuable to a broad range of developmental biologists.

   Reviewed by eLife

2. Inconsistencies between human and macaque lesion data can be resolved with a stimulus-computable model of the ventral visual stream

   This article has 2 authors:

   1. Tyler Bonnen
   2. Mark AG Eldridge

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study presents a useful application of a prior model published by the authors to a new dataset. The results from this approach were interesting and solid but the conclusions that one can make from the application of the model to only one paper are limited in scope and would depend on further probing to know if the model itself has face validity as a model of ventral visual stream function.

   Reviewed by eLife

3. We couldn't get details of this article at this time:
   10.1101/2022.11.23.517579

4. Opposing, spatially-determined epigenetic forces impose restrictions on stochastic olfactory receptor choice

   This article has 17 authors:

   1. Elizaveta V Bashkirova
   2. Nell Klimpert
   3. Kevin Monahan
   4. Christine E Campbell
   5. Jason Osinski
   6. Longzhi Tan
   7. Ira Schieren
   8. Ariel Pourmorady
   9. Beka Stecky
   10. Gilad Barnea
   11. Xiaoliang Sunney Xie
   12. Ishmail Abdus-Saboor
   13. Benjamin M Shykind
   14. Bianca J Marlin
   15. Richard M Gronostajski
   16. Alexander Fleischmann
   17. Stavros Lomvardas

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This is an important paper that revises the canonical model of how olfactory sensory neurons choose which odor receptor to express. The data presented in the paper are convincing and the model proposed is provocative and likely to enable future work.

   Reviewed by eLife

5. We couldn't get details of this article at this time:
   10.1101/2023.02.28.530337

6. We couldn't get details of this article at this time:
   10.1101/2023.03.30.534894

7. Robust membrane protein tweezers reveal the folding speed limit of helical membrane proteins

   This article has 4 authors:

   1. Seoyoon Kim
   2. Daehyo Lee
   3. WC Bhashini Wijesinghe
   4. Duyoung Min

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This work presents an important methodological advance for single-molecule force spectroscopy of membrane proteins providing a new robust design of the linkage between a target single molecule and solid support. The data provide compelling evidence of the improved mechanical stability of the pulling system. Allowing more statistically reliable force measurements of biomolecules, this method may be broadly applicable in the field of single-molecule biophysics.

   Reviewed by eLife

8. Cell Rearrangement Generates Pattern Emergence as a Function of Temporal Morphogen Exposure

   This article has 9 authors:

   1. Timothy Fulton
   2. Kay Spiess
   3. Lewis Thomson
   4. Yuxuan Wang
   5. Bethan Clark
   6. Seongwon Hwang
   7. Brooks Paige
   8. Berta Verd
   9. Benjamin Steventon

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     The authors present an exciting idea about how to integrate morphogens into a gene regulatory network with the dynamics of morphogenesis and cell movement. It represents a novel methodology, but in its current form the hypotheses, data and relationships described do not provide a sufficiently compelling model to disentangle cause and effect or elucidate the impact of cell movements on differentiation dynamics the zebrafish mesoderm.

   Reviewed by eLife, preLights

9. We couldn't get details of this article at this time:
   10.1101/2022.05.24.493217

10. Structural and mechanistic insights into the MCM8/9 helicase complex

    This article has 9 authors:

    1. Zhuangfeng Weng
    2. Jiefu Zheng
    3. Yiyi Zhou
    4. Zuer Lu
    5. Yixi Wu
    6. Dongyi Xu
    7. Huanhuan Li
    8. Huanhuan Liang
    9. Yingfang Liu

    This article has been curated by 1 group:

    • Curated by eLife

      eLife assessment

      This paper presents important findings on the hexametric structure of MCM8/9, which potentially explain its role as a DNA helicase in homologous recombination. This solid work will be of interest to biologists studying DNA transactions.

    Reviewed by eLife