eLife

Latest preprint reviews

1. Magnesium and the magnesium transporter UEX regulate sleep via Ca ²⁺ -dependent CREB signaling and a CNK-ERK pathway

   This article has 6 authors:

   1. Xin Yuan
   2. Huimei Zheng
   3. Xiao Xu
   4. Huan Deng
   5. Xiaohang Yang
   6. Yongmei Xi

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This manuscript provides valuable evidence for the role of magnesium homeostasis and relevant signaling pathway in Drosophila sleep regulation. It will be of interest to cellular biologists and neuroscientists interested in sleep:wake behavior and the potential role of magnesium in promoting sleep. Nevertheless, the evidence for the key claims of the manuscript is incomplete and is not fully supported by the data as reasonable alternative explanations exist.

   Reviewed by eLife

2. Quantitative analysis of rabies virus-based synaptic connectivity tracing

   This article has 3 authors:

   1. Alexandra Tran-Van-Minh
   2. Zhiwen Ye
   3. Ede Rancz

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     Tran-Van-Minh et al., attempt to develop a statistical approach which will allow consolidation of new, as well as previously-acquired datasets, to yield biologically significant insights into the logic underlying rabies vectors' expansion from single starter cells. While such work is called for, many of the premises presented here will need to be significantly adjusted, before the approach could be put into widespread use.

   Reviewed by eLife

3. Interdependent progression of bidirectional sister replisomes in E. coli

   This article has 6 authors:

   1. Po Jui Chen
   2. Anna B McMullin
   3. Bryan J Visser
   4. Qian Mei
   5. Susan M Rosenberg
   6. David Bates

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This paper reports a fundamental set of new results describing replisome organization and dynamics in E. coli. Cellular sites of active DNA replication (forks) spatially co-localize into structures termed replication factories, but the biological rationale for this fork co-localization has remained unknown. In an elegant study, the authors provide strong evidence that these factories are necessary to both coordinate and promote the progression of colocalized forks, and to help prevent them from spontaneously and prematurely dissociating. Through these findings, it is shown, for the first time, that replisomes' association has a beneficial impact on the bacterium. This is important work that provides robust data in favor of the factory and splitting model.

   Reviewed by eLife

4. Clarifying the role of an unavailable distractor in human multiattribute choice

   This article has 2 authors:

   1. Yinan Cao
   2. Konstantinos Tsetsos

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study presents an important finding on the decoy effect in multiattribute economic choices in humans. It makes a compelling case for the conclusion that the distractor effect reported in previous articles was confounded with the additive utility difference between the available alternatives. Though the contribution is somewhat narrowly focused with respect to the phenomenon that it addresses - the distractor effect in risky choice, it is important for understanding this particular phenomenon. The main weakness is the complexity of the current manuscript.

   Reviewed by eLife

5. Axo-vascular coupling mediated by oligodendrocytes

   This article has 9 authors:

   1. Alejandro Restrepo
   2. Andrea Trevisiol
   3. Camilo Restrepo-Arango
   4. Constanze Depp
   5. Andrew Octavian Sasmita
   6. Annika Keller
   7. Iva D. Tzvetanova
   8. Johannes Hirrlinger
   9. Klaus-Armin Nave

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This manuscript provides the first cellular analysis of how neuronal activity in axons (in this case the optic nerve) regulates the diameter of nearby blood vessels and hence the energy supply to neuronal axons and their associated cells. This is an important subject because, in a variety of neurological disorders, there is damage to the white matter that may result from a lack of sufficient energy supply. This paper will stimulate work on this important subject.

   Reviewed by eLife

6. Ultrastructural effects of sleep and wake on the parallel fiber synapses of the cerebellum

   This article has 11 authors:

   1. Sophia S Loschky
   2. Giovanna Maria Spano
   3. William Marshall
   4. Andrea Schroeder
   5. Kelsey Marie Nemec
   6. Shannon Sandra Schiereck
   7. Luisa de Vivo
   8. Michele Bellesi
   9. Sebastian Weyn Banningh
   10. Giulio Tononi
   11. Chiara Cirelli

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study provides compelling structural evidence on regulation of cerebellar synapses by sleep-wake states. The authors used serial block face scanning electron microscopy to obtain 3D reconstruction of more than 7,000 spines and their parallel fiber synapses in the mouse posterior vermis. The analysis shows that sleep increases the fraction of the 'naked' spines that don't carry a presynaptic partner at Purkinje cells. The authors propose that sleep promotes the pruning of branched synapses to single spines. This is an elegant and thorough study and the observations are important in light of the circuit-specific mechanisms by which sleep modulate synaptic structure and function.

   Reviewed by eLife

7. Single-cell transcriptomic profiling of the zebrafish inner ear reveals molecularly distinct hair cell and supporting cell subtypes

   This article has 8 authors:

   1. Tuo Shi
   2. Marielle O Beaulieu
   3. Lauren M Saunders
   4. Peter Fabian
   5. Cole Trapnell
   6. Neil Segil
   7. J Gage Crump
   8. David W Raible

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important study describes transcriptomic profiles of sensory and non-sensory cells of the zebrafish inner ear at single-cell resolution in embryonic through adult stages. These solid results catalogue transcriptomic data and show evidence that distinct cell subtypes exist between cells of the ear and the lateral line as well as within subcellular compartments in the inner ear. These findings provide information toward comparison studies of inner ear hair cell function in zebrafish and mammals.

   Reviewed by eLife

8. Nazo, the Drosophila homolog of the NBIA-mutated protein–c19orf12, is required for triglyceride homeostasis

   This article has 7 authors:

   1. Perinthottathil Sreejith
   2. Sara Lolo
   3. Kristen R. Patten
   4. Maduka Gunasinghe
   5. Neya More
   6. Leo J. Pallanck
   7. Rajnish Bharadwaj

   Reviewed by eLife

9. Soluble amyloid-β precursor peptide does not regulate GABAB receptor activity

   This article has 17 authors:

   1. Pascal Dominic Rem
   2. Vita Sereikaite
   3. Diego Fernández-Fernández
   4. Sebastian Reinartz
   5. Daniel Ulrich
   6. Thorsten Fritzius
   7. Luca Trovo
   8. Salomé Roux
   9. Ziyang Chen
   10. Philippe Rondard
   11. Jean-Philippe Pin
   12. Jochen Schwenk
   13. Bernd Fakler
   14. Martin Gassmann
   15. Tania Rinaldi Barkat
   16. Kristian Strømgaard
   17. Bernhard Bettler

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study refuted earlier work on the same subject. The two reviewers felt the manuscript was accurate, concise, and unbiased. The experimental evidence were thorough and supported the conclusions. The reviewers concurred the overall significance and quality of the experimental research were compelling and addressed previous work on this problem.

   Reviewed by eLife

10. Svep1 is a binding ligand of Tie1 and affects specific aspects of facial lymphatic development in a Vegfc-independent manner

    This article has 10 authors:

    1. Melina Hußmann
    2. Dörte Schulte
    3. Sarah Weischer
    4. Claudia Carlantoni
    5. Hiroyuki Nakajima
    6. Naoki Mochizuki
    7. Didier YR Stainier
    8. Thomas Zobel
    9. Manuel Koch
    10. Stefan Schulte-Merker

    This article has been curated by 1 group:

    • Curated by eLife

      eLife assessment

      This work reveals that lymphatic vascular development can occur independent of VegfC signaling, and that genetic interactions between a large extracellular matrix protein Svep1 and Tie1 receptor are important for the development of facial lymphatics and other aspects of lymphatic vascular development. The data link Svep1 to Tie1 signaling via elegant genetic experiments and provide important insights into a complex signaling pathway that is widely utilized in vascular development. The genetic evidence is convincing in supporting the findings that Tie1 but not Tie2 interacts with Svep1 in aspects of lymphangiogenesis.

    Reviewed by eLife