eLife

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1. We couldn't get details of this article at this time:
   10.1101/2023.02.20.529215

2. Maternal group 2 innate lymphoid cells contribute to fetal growth and protection from endotoxin-induced abortion in mice

   This article has 15 authors:

   1. Elisa Balmas
   2. Batika MJ Rana
   3. Russell S Hamilton
   4. Norman Shreeve
   5. Jens Kieckbusch
   6. Irving Aye
   7. Delia A Hawkes
   8. Sophie Trotter
   9. Jorge López-Tello
   10. Hannah EJ Yong
   11. Salvatore Valenti
   12. Amanda N Sferruzi-Perri
   13. Francesca Gaccioli
   14. Andrew NJ McKenzie
   15. Francesco Colucci

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important study describes the protective role of group 2 innate lymphoid cells (ILC2s) in tissue physiology and contributes to immunity, inflammatory pathology, and metabolism in maintaining homeostasis during pregnancy. The authors provide convincing evidence that ILC2s have new roles distinct from parasite protection and allergy inducers. Uterine ILC2s are key immune cells during normal and complicated pregnancies.

   Reviewed by eLife

3. Loss of the extracellular matrix protein Perlecan disrupts axonal and synaptic stability during Drosophila development

   This article has 4 authors:

   1. Ellen J Guss
   2. Yulia Akbergenova
   3. Karen L Cunningham
   4. J Troy Littleton

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study presents valuable new insights into the role of the extracellular matrix component (ECM) Perlecan in axon integrity, with downstream consequences for the maintenance of synaptic structures. The evidence for Perlecan's role in this process is solid, although negative results for Perlecan's mechanism of action should be strengthened with the addition of appropriate controls centered on the relevant pathways and mechanisms involved as well as more careful analyses and interpretations. The authors provide convincing data identifying and describing the cellular sequence from ECM perturbations to axonal and synaptic degeneration, but additional data pinpointing the requirements of Perlecan for axonal maintenance would further improve the impact of this study.

   Reviewed by eLife

4. Spatiotemporal dynamics of sensory neuron and Merkel-cell remodeling are decoupled during epidermal homeostasis

   This article has 3 authors:

   1. Rachel C. Clary
   2. Blair A. Jenkins
   3. Ellen A. Lumpkin

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     The present study offers valuable insights into the remodeling of Merkel cells and their innervating sensory axons in the skin. This remodelling seems to be mostly played out independently between the two synaptic partners revealing significant Merkel cell turnover and axonal plasticity. The authors employed live imaging and quantification tools using genetic models in which parts of the mechanosensory organs of the skin are labelled with distinct fluorescent proteins. While most of the data, and their interpretations are solid, the analyses of Merkel cell number homeostasis remain incomplete.

   Reviewed by eLife

5. We couldn't get details of this article at this time:
   10.1101/2023.03.08.23286896

6. We couldn't get details of this article at this time:
   10.1101/2022.08.15.504010

7. Scorpionfish BPI is highly active against multiple drug-resistant Pseudomonas aeruginosa isolates from people with cystic fibrosis

   This article has 11 authors:

   1. Jonas Maurice Holzinger
   2. Martina Toelge
   3. Maren Werner
   4. Katharina Ursula Ederer
   5. Heiko Ingo Siegmund
   6. David Peterhoff
   7. Stefan Helmut Blaas
   8. Nicolas Gisch
   9. Christoph Brochhausen
   10. André Gessner
   11. Sigrid Bülow

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     In this useful study, Holzinger et al. present compelling evidence that scorpionfish bactericidal/permeability-increasing protein (scoBPI) exhibits remarkable antibacterial activity against multi-drug resistant Pseudomonas aeruginosa. These findings open new avenues of research for identifying novel chemotherapies to treat Pseudomonas infections and have broader implications in developing chemotherapies against other drug-resistant Gram-negative bacterial infections. The work will be of interest to individuals investigating novel cystic fibrosis antimicrobials.

   Reviewed by eLife

8. Epigenetically distinct synaptic architecture in clonal compartments in the teleostean dorsal pallium

   This article has 8 authors:

   1. Yasuko Isoe
   2. Ryohei Nakamura
   3. Shigenori Nonaka
   4. Yasuhiro Kamei
   5. Teruhiro Okuyama
   6. Naoyuki Yamamoto
   7. Hideaki Takeuchi
   8. Hiroyuki Takeda

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment:

     This important paper highlights the clonal organization of the dorsal telencephalon, a major region of the vertebrate brain, and analyzes the distinctive gene expression and chromatin accessibility present in each clonal using the adult teleost fish medaka. High-quality data were collected using convincing and solid methods and these were used to identify synaptic genes with a distinct chromatin landscape and expression in one of the regions of the dorsal pallium, with the goal of ascribing an evolutionary origin to these neurons.

   Reviewed by eLife

9. Adult-born granule cells improve stimulus encoding and discrimination in the dentate gyrus

   This article has 3 authors:

   1. Diego M Arribas
   2. Antonia Marin-Burgin
   3. Luis G Morelli

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This paper is of potential interest to both the hippocampal and computational neuroscience fields because it provides a framework for understanding how adult-born granule cells in the hippocampus contribute to network processing. It contains novel interesting ideas, such as the analysis of input-output transformation by SRM models and the establishment of "greedy networks". However, not all major conclusions are sufficiently supported by the data. The paper demonstrates that mixed networks show better encoding performance than pure networks, but the differences are small and only visible with specific performance metrics. Intuitive explanations are not provided.

   Reviewed by eLife

10. The yeast endocytic early/sorting compartment exists as an independent sub-compartment within the trans-Golgi network

    This article has 7 authors:

    1. Junko Y Toshima
    2. Ayana Tsukahara
    3. Makoto Nagano
    4. Takuro Tojima
    5. Daria E Siekhaus
    6. Akihiko Nakano
    7. Jiro Toshima

    This article has been curated by 1 group:

    • Curated by eLife

      eLife assessment

      In this study, the authors use high-speed and high-resolution imaging to investigate the role of the yeast syntaxin homolog Tlg2p in endocytic vesicle sorting. They obtain compelling data to show that the Tlg2p-residing compartment within the trans-Golgi network functions as an early/sorting compartment, where endocytic cargos are sorted to either the recycling pathway or the endo-lysosomal pathway. The authors also describe additional molecular details of this sorting process, and overall provide important insights into the mechanism of endocytic vesicle sorting in budding yeast.

    Reviewed by eLife