eLife

Latest preprint reviews

1. We couldn't get details of this article at this time:
   10.1101/2023.01.03.522583

2. Mesotrode allows chronic simultaneous mesoscale cortical imaging and subcortical or peripheral nerve spiking activity recording in mice

   This article has 3 authors:

   1. Dongsheng Xiao
   2. Yuhao Yan
   3. Timothy H Murphy

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This valuable study combines chronic widefield calcium imaging of dorsal cortex activity at the mesoscale level with electrical recording of single neurons in specific cortical and subcortical locations. This work provides compelling evidence for recording neuronal activity at multiple temporal and spatial scales by combination of optical and electrophysiological methods. This work will be of broad interest to system neuroscientists studying neural circuits.

   Reviewed by eLife

3. We couldn't get details of this article at this time:
   10.1101/2023.01.19.521267

4. Approach-avoidance reinforcement learning as a translational and computational model of anxiety-related avoidance

   This article has 3 authors:

   1. Yumeya Yamamori
   2. Oliver J Robinson
   3. Jonathan P Roiser

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This is a valuable paper demonstrating the validity of a novel task that could advance the field of reinforcement learning to better incorporate threat processing in approach-avoidance-conflict. A compelling methodology includes the use of online samples and computational modelling, psychometrics, discovery/replication and pre-registration. This work provides a foundation for future work, which is required to establish this task as relevant to psychopathology and treatment.

   Reviewed by eLife

5. We couldn't get details of this article at this time:
   10.1101/2023.02.11.528119

6. Mechanism of stepwise electron transfer in six-transmembrane epithelial antigen of the prostate (STEAP) 1 and 2

   This article has 6 authors:

   1. Kehan Chen
   2. Lie Wang
   3. Jiemin Shen
   4. Ah-Lim Tsai
   5. Ming Zhou
   6. Gang Wu

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study provides useful insights into the mechanisms of electron transport in STEAP proteins, consistent with current models. The work strengthens and supports previously published biochemical and structural data, and the experimental results are of solid technical quality. The manuscript will be of interest to colleagues who work on STEAP proteins and related electron transfer systems.

   Reviewed by eLife

7. We couldn't get details of this article at this time:
   10.1101/2023.02.02.526762

8. Bactabolize is a tool for high-throughput generation of bacterial strain-specific metabolic models

   This article has 9 authors:

   1. Ben Vezina
   2. Stephen C Watts
   3. Jane Hawkey
   4. Helena B Cooper
   5. Louise M Judd
   6. Adam WJ Jenney
   7. Jonathan M Monk
   8. Kathryn E Holt
   9. Kelly L Wyres

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study presents Bactabolize, a valuable tool for the rapid genome-scale reconstruction of bacteria and the prediction of growth phenotypes. Using validated methodology, the tool relies on a reference pan-genome model to create strain-specific draft metabolic models, as demonstrated in this study using Klebsiella pneumoniae. While the evidence in this specific case is solid, validation across diverse bacterial species is yet to be confirmed.

   Reviewed by eLife

9. We couldn't get details of this article at this time:
   10.1101/2023.02.25.530042

10. Replisome loading reduces chromatin motion independent of DNA synthesis

    This article has 13 authors:

    1. Maruthi Kumar Pabba
    2. Christian Ritter
    3. Vadim O Chagin
    4. Janis Meyer
    5. Kerem Celikay
    6. Jeffrey H Stear
    7. Dinah Loerke
    8. Ksenia Kolobynina
    9. Paulina Prorok
    10. Alice Kristin Schmid
    11. Heinrich Leonhardt
    12. Karl Rohr
    13. M Cristina Cardoso

    This article has been curated by 1 group:

    • Curated by eLife

      eLife assessment

      This is a valuable investigation of the chromatin dynamics throughout the cell cycle by using fluorescence signals and patterns of GFP-PCNA and CY3-dUTP, which labels newly synthesized DNA. The authors report reduced chromatin mobility in S relative to G1 phase. The technology and methods used are solid. The data will be of interest to researchers working on chromatin dynamics.

    Reviewed by eLife