eLife

Latest preprint reviews

1. Transcriptional control of motor pool formation and motor circuit connectivity by the LIM-HD protein Isl2

   This article has 13 authors:

   1. Yunjeong Lee
   2. In Seo Yeo
   3. Namhee Kim
   4. Dong-Keun Lee
   5. Kyung-Tai Kim
   6. Jiyoung Yoon
   7. Jawoon Yi
   8. Young Bin Hong
   9. Byung-Ok Choi
   10. Yoichi Kosodo
   11. Daesoo Kim
   12. Jihwan Park
   13. Mi-Ryoung Song

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This paper will be of interest to developmental biologists who study the gene regulatory mechanisms necessary for neuronal identity and circuit assembly. The study presents important findings regarding the role of the LIM homeodomain transcription factor Isl2 in the development of spinal motor neurons. While the importance of Isl2 for the acquisition of axial and visceral motor neuron development was already described in the literature, the data convincingly describe an additional role in the differentiation of a subset of limb-innervating motor neurons.

   Reviewed by eLife

2. Down-regulated GAS6 impairs synovial macrophage efferocytosis and promotes obesity-associated osteoarthritis

   This article has 14 authors:

   1. Zihao Yao
   2. Weizhong Qi
   3. Hongbo Zhang
   4. Zhicheng Zhang
   5. Liangliang Liu
   6. Yan Shao
   7. Hua Zeng
   8. Jianbin Yin
   9. Haoyan Pan
   10. Xiongtian Guo
   11. Anling Liu
   12. Daozhang Cai
   13. Xiaochun Bai
   14. Haiyan Zhang

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     The authors demonstrate that patients with obesity-associated osteoarthritis and mice with the ApoE gene deficiency showed phenotypes of synovitis and enhanced macrophage infiltration in synovial tissues. Overall, this potentially important study is well-designed and carefully executed, although additional evidence is needed to fully support the authors' conclusions.

   Reviewed by eLife

3. MHC class I and MHC class II reporter mice enable analysis of immune oligodendroglia in mouse models of multiple sclerosis

   This article has 9 authors:

   1. Em P Harrington
   2. Riley B Catenacci
   3. Matthew D Smith
   4. Dongeun Heo
   5. Cecilia E Miller
   6. Keya R Meyers
   7. Jenna Glatzer
   8. Dwight E Bergles
   9. Peter A Calabresi

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study reports an important new resource, MHC class I and MHC class II reporter mice, which provide a means to monitor MHC activation in vivo. The authors use these mice to study inflammatory demyelination in two mouse models of multiple sclerosis. The study provides a compelling demonstration of the new reporter lines as a valuable tool for analysis of inflammation and neurodegeneration.

   Reviewed by eLife

4. TMS-evoked responses are driven by recurrent large-scale network dynamics

   This article has 3 authors:

   1. Davide Momi
   2. Zheng Wang
   3. John D Griffiths

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This manuscript presents a valuable new approach to modelling patterns of brain activity evoked by non-invasive brain stimulation, shedding light on how such stimulation drives neuronal dynamics. The performance of the model is impressive and its validity is supported by solid evidence. This work will be of interest to researchers working in computational neuroscience, neuroimaging, and non-invasive brain stimulation.

   Reviewed by eLife

5. Testing the ion-current model for flagellar length sensing and IFT regulation

   This article has 5 authors:

   1. Hiroaki Ishikawa
   2. Jeremy Moore
   3. Dennis R Diener
   4. Markus Delling
   5. Wallace F Marshall

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This paper is valuable and of interest to scientists studying primary cilia/flagellar formation and regulation. It addresses how ciliary/flagellar length is controlled and whether calcium negatively regulates Intraflagellar transport (IFT) injection. The study convincingly demonstrates that calcium influx correlates with flagellar length, but calcium does not appear to work as a negative regulator of IFT injection, which challenges a previous model. The models and methods are generally sound, but some conclusions would be strengthened by additional experimental support.

   Reviewed by eLife

6. In-line swimming dynamics revealed by fish interacting with a robotic mechanism

   This article has 2 authors:

   1. Robin Thandiackal
   2. George Lauder

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     Why do fish school together? Energetic benefits have long been considered a key factor in motivating fish to swim together and tune their tail beat to exploit the whirling wake generated by conspecifics. This study clearly demonstrates that fish benefit from swimming in a two-dimensional vortical wake by locating their body in the vortical low-pressure zones that passively impart a net thrust force on their oscillating bodies. The behavioral and biofluid mechanical findings will interest comparative biomechanists, movement ecologists, evolutionary biologists, fluid mechanists, and bioinspired roboticists.

   Reviewed by eLife

7. Cryo-EM structures of mitochondrial respiratory complex I from Drosophila melanogaster

   This article has 5 authors:

   1. Ahmed-Noor A Agip
   2. Injae Chung
   3. Alvaro Sanchez-Martinez
   4. Alexander J Whitworth
   5. Judy Hirst

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important study advances our understanding of respiratory complex I. The authors present convincing structural data for the enzyme from Drosophila melanogaster although the interpretation of conformational states is still not conclusively settled. This work will be of interest to researchers studying respiratory enzymes, the evolution of respiration, and mitochondrial diseases.

   Reviewed by eLife

8. Single-cell transcriptome profiles of Drosophila fruitless-expressing neurons from both sexes

   This article has 6 authors:

   1. Colleen M Palmateer
   2. Catherina Artikis
   3. Savannah G Brovero
   4. Benjamin Friedman
   5. Alexis Gresham
   6. Michelle N Arbeitman

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This manuscript will be of interest to both developmental biologists and neuroscientists. The data suggest that most (but not all) neuronal types are present in both Drosophila sexes, and the existence of mostly shared scSeq clusters suggests that sex-specific versions of the transcription factor Fruitless can modify neural function in a sex-specific way without completely altering core neural identity. This cell type gene expression atlas should prove valuable in future efforts to understand mechanisms of sex-specific development, as well as the molecular and developmental-genetic basis of sex differences in behaviour.

   Reviewed by eLife

9. Structure-based prediction of T cell receptor:peptide-MHC interactions

   This article has 1 author:

   1. Philip Bradley

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     The author customises an alpha-fold multimer neural network to predict TCR-pMHC and applies this to the problem of identifying peptides from a limited library, that might engage TCR with a known sequence from a limited list of potential peptides. This is an important structural problem and a useful step that can be further improved through better metrics, comparison to existing approaches, and consideration of the sensitivity of the recognition processes to small changes in structure.

   Reviewed by eLife

10. Nucleotide binding is the critical regulator of ABCG2 conformational transitions

    This article has 11 authors:

    1. Zsuzsanna Gyöngy
    2. Gábor Mocsár
    3. Éva Hegedűs
    4. Thomas Stockner
    5. Zsuzsanna Ritter
    6. László Homolya
    7. Anita Schamberger
    8. Tamás I Orbán
    9. Judit Remenyik
    10. Gergely Szakacs
    11. Katalin Goda

    This article has been curated by 1 group:

    • Curated by eLife

      eLife assessment

      The ABC transporter ABCG2 extrudes chemotherapy reagents and other xenobiotics from a number of different tissues. How ABCG2 operates at the molecular level has been largely derived from structures and dynamics carried out in non-physiological environments. The paper presents convincing cell-based evidence describing the relationship between structural changes of ABCG2 and substrate binding using flow cytometry, confocal microscopy, and fluorescence-correlation spectroscopy methods. Both the mechanistic conclusions and methodology employed offer important insights, which will be of general interest to the biochemistry and transport biology communities.

    Reviewed by eLife