eLife

Latest preprint reviews

1. In vitro reconstitutions suggest a general model for paradoxical activation of ARAF, BRAF, and CRAF by diverse RAF inhibitor types that does not rely on negative allostery

   This article has 5 authors:

   1. Emre Tkacik
   2. Dong Man Jang
   3. Kayla Boxer
   4. Byung Hak Ha
   5. Michael J Eck

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This paper's biochemical studies of the mechanisms underlying paradoxical activation of RAF family kinases by small-molecule inhibitors have uncovered some important new features of this process by establishing a role for the N-terminal acidic (NtA) motif and showing that CRAF and ARAF can also exhibit paradoxical activation. However, there are substantial criticisms that can be made regarding the data analysis and the evidence for the authors' new model that paradoxical activation does not rely on negative allostery is considered incomplete.

   Reviewed by eLife

2. We couldn't get details of this article at this time:
   10.1101/2024.09.23.614335

3. Engineering ATP Import in Yeast Uncovers a Synthetic Route to Extend Cellular Lifespan

   This article has 11 authors:

   1. Naci Oz
   2. Hetian Su
   3. Vedat Sari
   4. Praveen Patnaik
   5. Rohil Hameed
   6. Jong Hee Song
   7. Derek C Prosser
   8. Vyacheslav M Labunskyy
   9. Vadim N Gladyshev
   10. Nan Hao
   11. Alaattin Kaya

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This manuscript addresses an important and conceptually ambitious question by using a synthetic biology strategy to perturb ATP homeostasis in yeast and examine its causal relationship with lifespan. While the experimental approach and lifespan data are intriguing, the current evidence is incomplete and internally inconsistent, particularly regarding intracellular ATP measurements, transporter directionality, mitochondrial dependence, and the proposed mechanistic model. Substantial clarification, additional controls, and further experimentation will be necessary before the main conclusions can be considered robust and the biological significance of the findings can be fully assessed.

   Reviewed by eLife

4. Inhibition of Slc17a7 expressing neurons in the basolateral amygdala which project to the nucleus accumbens shapes the fidelity of motivated behavior

   This article has 7 authors:

   1. William D Mercer
   2. Iltan Aklan
   3. Nathaniel E Connolly
   4. Shivangi M Inamdar
   5. Benjamin L Fisher
   6. Chase M Larsson
   7. Kyle H Flippo

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This useful study uses in vitro electrophysiology, projection-specific chemogenetics, and different behavioural tasks to investigate the role of Vglut1-expression in basolateral amygdala neurons projecting to the nucleus accumbens in aspects of motivated behaviour. Although the manuscript is clearly written, the strength of the evidence supporting claims about the role of this pathway is incomplete. Currently, the work may be of interest to some behavioural neuroscientists, but additional controls and further clarification of specific analyses would strengthen their broader significance.

   Reviewed by eLife

5. Cortex-wide Dynamics of Internal Decisions About Behavioral Context

   This article has 5 authors:

   1. Joshua Calder-Travis
   2. Ruud L van den Brink
   3. Saanchi Thawani
   4. Lars Schwabe
   5. Tobias H Donner

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     In this study, the authors investigated how inference about the current task context, by weighting evidence based on surprise and uncertainty in the environment, is encoded in the cortex. Using MEG imaging and an impressive amount of analytic work based on normative decision modeling, they provided solid evidence for the involvement of the visual and parietal cortex. These results are a valuable complement to and extension of a previous study using fMRI measurements, by identifying the candidate regions that are of importance for the inference process, not just for encoding the end product.

   Reviewed by eLife

6. We couldn't get details of this article at this time:
   10.1101/2025.09.24.678251

7. Early Sleep-Dependent Sensory Gating in the Olfactory System

   This article has 8 authors:

   1. Diego Serantes
   2. Diego Gallo
   3. Anttonella García
   4. Joaquín González
   5. Mateo Mendoza
   6. Patricia Lagos
   7. Pablo Torterolo
   8. Matías Cavelli

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study presents a well-executed investigation into how the olfactory system disconnects from the environment during sleep and anesthesia, identifying a potential gating mechanism at the earliest synaptic stages of the olfactory bulb. The findings are important, as they challenge current theories by demonstrating that sensory gating occurs in non-thalamic pathways even under controlled airflow conditions. The strength of evidence is solid, supported by rigorous multimodal recordings, although the reliance on anesthetic models to draw conclusions about natural sleep is a limitation that requires further contextualization.

   Reviewed by eLife

8. We couldn't get details of this article at this time:
   10.64898/2026.01.16.699953

9. We couldn't get details of this article at this time:
   10.64898/2026.01.02.697337

10. We couldn't get details of this article at this time:
    10.64898/2025.12.25.696505