eLife

Latest preprint reviews

1. Germinal center B cells that acquire nuclear proteins are specifically suppressed by follicular regulatory T cells

   This article has 7 authors:

   1. Fang Ke
   2. Zachary L Benet
   3. Mitra P Maz
   4. Jianhua Liu
   5. Alexander L Dent
   6. Joanne Michelle Kahlenberg
   7. Irina L Grigorova

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     It is well known that Tfr cells have the capacity to preferentially suppress autoimmune antibody responses, but it is not known why such specificity exists. This important work provides new information as to how self-reactive antibody responses are regulated and has significant implications to the fields of autoimmunity and vaccine design. The overall experimental designs and the data quality are largely convincing, but the authors should include more careful controls.

   Reviewed by eLife

2. Time-varying and tissue-dependent effects of adiposity on leptin levels: A Mendelian randomization study

   This article has 3 authors:

   1. Tom G Richardson
   2. Genevieve M Leyden
   3. George Davey Smith

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     The authors have combined their two recently developed novel approaches to Mendelian randomization studies (1) Lifecourse mendelian randomization which relates genes to the outcome, eg obesity, at different stages of life, and (2) Tissue partitioned mendelian randomization to determine if there are different genetic effects in different tissues. They have successfully combined these two approaches to investigate the influence of adiposity on circulating leptin in childhood and adulthood to demonstrate the value/proof of concept of combining these two techniques. This is very clearly presented and well-conducted work showing both new methodology and compelling results and will be important to both those who use Mendelian randomization and those who are interested in obesity.

   Reviewed by eLife

3. Liver type 1 innate lymphoid cells lacking IL-7 receptor are a native killer cell subset fostered by parenchymal niches

   This article has 13 authors:

   1. Takuma Asahi
   2. Shinya Abe
   3. Guangwei Cui
   4. Akihiro Shimba
   5. Tsukasa Nabekura
   6. Hitoshi Miyachi
   7. Satsuki Kitano
   8. Keizo Ohira
   9. Johannes M Dijkstra
   10. Masaki Miyazaki
   11. Akira Shibuya
   12. Hiroshi Ohno
   13. Koichi Ikuta

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study provides important insights on the developmental process and functional heterogeneity of liver ILC1s, especially how IL-7R+ and IL-7R- ILC1s are generated. Authors present compelling evidence on the dependence of ILC1s on IL-7R- precursor and their reliance on IL-15 to develop cytotoxic functions. The work will be of broad interest to immunologists and liver biologists.

   Reviewed by eLife

4. Imprinted Dlk1 dosage as a size determinant of the mammalian pituitary gland

   This article has 8 authors:

   1. Valeria Scagliotti
   2. Maria Lillina Vignola
   3. Thea Willis
   4. Mark Howard
   5. Eugenia Marinelli
   6. Carles Gaston-Massuet
   7. Cynthia Andoniadou
   8. Marika Charalambous

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important study uses elegant in vivo experiments combined with expression data on an imprinted gene, Dlk1, to demonstrate its role in pituitary gland size in mice. The evidence supporting the claims of the authors is solid, although the inclusion of both sexes and a rescue model would have strengthened the study. The work will be of interest to developmental biologists working on the pituitary and hypothalamus.

   Reviewed by eLife

5. Theta-phase-specific modulation of dentate gyrus memory neurons

   This article has 10 authors:

   1. Bahar Rahsepar
   2. Jacob F Norman
   3. Jad Noueihed
   4. Benjamin Lahner
   5. Melanie H Quick
   6. Kevin Ghaemi
   7. Aashna Pandya
   8. Fernando R Fernandez
   9. Steve Ramirez
   10. John A White

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study represents an important step toward unifying two strains of inquiry, one related to the functional role of hippocampal theta oscillations and one related to the behavioral impact of engram reactivation, and thus the findings have implications for our understanding of memory that will impact multiple subfields. In combination with additional context from the literature, the important findings are supported by solid evidence supporting the conclusion that memory recall operations occur preferentially at a specific phase of theta.

   Reviewed by eLife

6. Bilateral JNK activation is a hallmark of interface surveillance and promotes elimination of aberrant cells

   This article has 5 authors:

   1. Deepti Prasad
   2. Katharina Illek
   3. Friedericke Fischer
   4. Katrin Holstein
   5. Anne-Kathrin Classen

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This is an interesting study investigating a mechanism for the elimination of aberrant cells from epithelial tissues dependent on the contractility of the interface between cells with different fates regulated by JNK activity. This work offers insights into robustness and error correction mechanisms that help understand cell-cell competition and the origin of tumors. The study should be relevant for cell, developmental and cancer biologists.

   Reviewed by eLife

7. Structural features stabilized by divalent cation coordination within hepatitis E virus ORF1 are critical for viral replication

   This article has 7 authors:

   1. Robert LeDesma
   2. Brigitte Heller
   3. Abhishek Biswas
   4. Stephanie Maya
   5. Stefania Gili
   6. John Higgins
   7. Alexander Ploss

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     The paper aims to provide structural and functional information on the hepatitis E virus replication complex. The study will be of interest to a broad number of people studying at virus replication, since the replication complex are targets for therapeutic interventions.

   Reviewed by eLife

8. Enteroendocrine cell lineages that differentially control feeding and gut motility

   This article has 7 authors:

   1. Marito Hayashi
   2. Judith A Kaye
   3. Ella R Douglas
   4. Narendra R Joshi
   5. Fiona M Gribble
   6. Frank Reimann
   7. Stephen D Liberles

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     As digested food moves through the intestines specialized epithelial cells (called Enterochromaffin Cells or EECs) sense and respond to the constituent chemicals. The current work utilizes single-cell transcriptomic analyses and intersectional approaches to define and genetically manipulate subsets of EECs. Key findings are that direct stimulation of EEC subtypes influences key aspects of feeding, specifically gut transit, ingestion, and food preference.

   Reviewed by eLife

9. Cohesin-independent STAG proteins interact with RNA and R-loops and promote complex loading

   This article has 13 authors:

   1. Hayley Porter
   2. Yang Li
   3. Maria Victoria Neguembor
   4. Manuel Beltran
   5. Wazeer Varsally
   6. Laura Martin
   7. Manuel Tavares Cornejo
   8. Dubravka Pezić
   9. Amandeep Bhamra
   10. Silvia Surinova
   11. Richard G Jenner
   12. Maria Pia Cosma
   13. Suzana Hadjur

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study provides evidence that the Stromalin Antigen (SA) proteins known to ubiquitously interact with cohesins, retain their capacity to bind CTCF and chromatin in the absence of RAD21 cohesin component. Authors imply that SA has an independent function in addition to its joint role with RAD21 and CTCF, providing experiments that make them suggest that SA proteins organize around RNA:DNA regions in the absence of cohesin, contributing to R-loop regulation and linking chromatin on structure to cohesin loading. The paper is a nice piece of work of interest to readers in the field of cohesin biology and genome organization. However, additional, experiments would be required to strengthen some of the conclusions.

   Reviewed by eLife

10. Palmitoylation regulates neuropilin-2 localization and function in cortical neurons and conveys specificity to semaphorin signaling via palmitoyl acyltransferases

    This article has 7 authors:

    1. Eleftheria Koropouli
    2. Qiang Wang
    3. Rebeca Mejías
    4. Randal Hand
    5. Tao Wang
    6. David D Ginty
    7. Alex L Kolodkin

    This article has been curated by 1 group:

    • Curated by eLife

      eLife assessment

      Signaling mediated by Semaphorins and their receptors Nrp1 and Nrp2 is crucial for regulating the morphology of dendritic spines and dendritic arborization during development. In this manuscript, the authors found that the post-translational modification of S-palmitoylation dictates the subcellular localization and trafficking of Nrp2, but not Nrp1, and is required for Sema3F-dependent pruning of spines on the apical dendrites of layer V cortical neurons. The study provides important insights into how semaphorin signaling achieves spatial specificity on diverse downstream cellular events.

    Reviewed by eLife