Latest preprint reviews

  1. Sensory neurons couple arousal and foraging decisions in Caenorhabditis elegans

    This article has 2 authors:
    1. Elias Scheer
    2. Cornelia I Bargmann
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This is an important study on how behavioral context affects decision making in the nematode C. elegans. Behavioral analyses at multiple time scales combined with genetic and neuronal manipulations revealed how arousal states affect decision making. The results and interpretations are convincing. This work will be of interest to both neuroscientists and ecologists.

    Reviewed by eLife

    This article has 9 evaluationsAppears in 1 listLatest version Latest activity
  2. Network-level changes in the brain underlie fear memory strength

    This article has 2 authors:
    1. Josue Haubrich
    2. Karim Nader
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This important study provides convincing data in support of the conclusion that weak but not strong fear memories are more easily modified using behavioural and pharmacological approaches potentially as a result of differential connectivity with the amygdala showing greater connectivity through the brain in weak compared to strong memories. The scope of the paper would be strengthened if both sexes were examined and more varied definitions of weak vs. strong memories were used. This paper is of interest to behavioural and neuroscience researchers studying learning, memory, and/or neural networks.

    Reviewed by eLife

    This article has 8 evaluationsAppears in 1 listLatest version Latest activity
  3. A computationally informed comparison between the strategies of rodents and humans in visual object recognition

    This article has 4 authors:
    1. Anna Elisabeth Schnell
    2. Maarten Leemans
    3. Kasper Vinken
    4. Hans Op de Beeck
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      Schnell et al report important differences between the strategies used by rodents and humans when discriminating different visual objects. The evidence supporting these findings is convincing, showing that rat performance was influenced far more by low-level cues compared to humans. It is, however, unclear to what extent these differences can be explained by the lower visual acuity of rats. This work will be of general interest to vision and cognition researchers, particularly those studying object vision.

    Reviewed by eLife

    This article has 8 evaluationsAppears in 1 listLatest version Latest activity
  4. C-type natriuretic peptide improves maternally aged oocytes quality by inhibiting excessive PINK1/Parkin-mediated mitophagy

    This article has 12 authors:
    1. Hui Zhang
    2. Chan Li
    3. Qingyang Liu
    4. Jingmei Li
    5. Hao Wu
    6. Rui Xu
    7. Yidan Sun
    8. Ming Cheng
    9. Xiaoe Zhao
    10. Menghao Pan
    11. Qiang Wei
    12. Baohua Ma
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment:

      This study presents valuable findings on the impact of C-natriuretic peptide (CNP) treatment in vivo on the fertility of aged mice. Solid data indicate CNP induces the cAMP-PKA pathway, causing reduced recruitment of Parkin protein to mitochondria in oocytes, resulting in reduced mitophagy, which may be significant for increased mitochondrial bioenergetics and improved cytoplasmic and nuclear maturation. The authors make additional claims regarding the mechanisms by which CNP impacts oocyte quality in vivo for which the evidence is inconclusive. This work will be of interest to reproductive biologists and clinical infertility specialists.

    Reviewed by eLife

    This article has 6 evaluationsAppears in 1 listLatest version Latest activity
  5. SIRT-1 is required for release of enveloped enteroviruses

    This article has 8 authors:
    1. Alagie Jassey
    2. James Logue
    3. Stuart Weston
    4. Michael A Wagner
    5. Ganna Galitska
    6. Katelyn Miller
    7. Matthew Frieman
    8. William T Jackson
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      The presence or absence of a surrounding envelope, previously a clear distinguishing feature of different viruses, has been blurred by the recent recognition that many so-called 'nonenveloped' viruses are released from cells as quasi-enveloped virions cloaked in host cell membranes. This mechanism of viral egress allows for non-lytic infection, and has potentially important implications for pathogenesis. In this manuscript, Jassey and colleagues provide solid evidence that the protein deacetylase SIRT-1 is required for the non-lytic release of enteroviruses in extracellular vesicles.

    Reviewed by eLife

    This article has 6 evaluationsAppears in 1 listLatest version Latest activity
  6. Genetic and karyotype divergence between parents affect clonality and sterility in hybrids

    This article has 12 authors:
    1. Anatolie Marta
    2. Tomáš Tichopád
    3. Oldřich Bartoš
    4. Jiří Klíma
    5. Mujahid Ali Shah
    6. Vendula Šlechtová Bohlen
    7. Joerg Bohlen
    8. Karel Halačka
    9. Lukáš Choleva
    10. Matthias Stöck
    11. Dmitrij Dedukh
    12. Karel Janko
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This paper provides important insights into how asexual reproduction can arise in interspecific hybrids. The evidence supporting the conclusions is compelling, with rigorous molecular cytogenetic experiments showing the production of clonal gametes is common across hybrids between closely to moderately divergent sexual species. By highlighting the potential for asexuality to evolve in hybrids during a narrow window of species divergence, this work will be of broad interest to evolutionary biologists.

    Reviewed by eLife

    This article has 7 evaluationsAppears in 1 listLatest version Latest activity
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