eLife

Latest preprint reviews

1. Dynamic regulation of inter-organelle communication by ubiquitylation controls skeletal muscle development and disease onset

   This article has 18 authors:

   1. Arian Mansur
   2. Remi Joseph
   3. Euri S Kim
   4. Pierre M Jean-Beltran
   5. Namrata D Udeshi
   6. Cadence Pearce
   7. Hanjie Jiang
   8. Reina Iwase
   9. Miroslav P Milev
   10. Hashem A Almousa
   11. Elyshia McNamara
   12. Jeffrey Widrick
   13. Claudio Perez
   14. Gianina Ravenscroft
   15. Michael Sacher
   16. Philip A Cole
   17. Steven A Carr
   18. Vandana A Gupta

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important work utilizes a model organism, zebrafish, to explore changes to the proteome and the role of KLHL40, a component of the ubiquitin-proteasome system, in the development of skeletal muscle disease. Using mass spectrometry, the authors demonstrate a major and selective role for proteome remodeling in development. They identify a specific role for KLHL40 deletion in regulating the expression of Sar1 - a key component of biosynthetic secretion, where the resulting elevated levels of Sar1 expression potentially lead to collagen secretion defects in the disease state. The findings are incomplete as further experimental characterization of the overall morphological changes and secretion defects, in particular ones derived from the deregulation of Sar1 levels, is required.

   Reviewed by eLife

2. The mutational signatures of poor treatment outcomes on the drug-susceptible Mycobacterium tuberculosis genome

   This article has 5 authors:

   1. Yiwang Chen
   2. Qi Jiang
   3. Mijiti Peierdun
   4. Howard E Takiff
   5. Qian Gao

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     In this useful study, a GWAS-type analysis is applied to clinical Mycobacterium tuberculosis isolates to discover genetic polymorphisms linked to poor tuberculosis outcomes. The evidence for the detected associations is still incomplete, as the corresponding polymorphisms are not adequate to power a prediction model for infection outcome, although key host factors - including patient age, sex, and duration of diagnostic delay (which have stronger predictive value) - appear to enhance predictive capacity.

   Reviewed by eLife

3. Single-cell transcriptomic atlas of lung microvascular regeneration after targeted endothelial cell ablation

   This article has 9 authors:

   1. Rafael Soares Godoy
   2. Nicholas D Cober
   3. David P Cook
   4. Emma McCourt
   5. Yupu Deng
   6. Liyuan Wang
   7. Kenny Schlosser
   8. Katelynn Rowe
   9. Duncan J Stewart

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment:

     The manuscript by Godoy and colleagues is an important contribution to the understanding of how lung endothelial regeneration progresses following endothelial ablation. The novelty and elegance of this study are rooted in the regional and specific ablation of lung endothelial cells using diphtheria toxin without the massive inflammatory activation that is seen with lung injury induced by bacterial infections, viral infections, or lipopolysaccharide. The data convincingly demonstrate that there is an emergence of a highly proliferative lung endothelial subpopulation that drives endothelial regeneration. The translational implications of the study include the identification of potential therapeutic targets to augment endothelial regeneration as a treatment for ALI/ARDS. This study will be of interest to vascular biologists, lung biologists, and researchers studying adult tissue regeneration.

   Reviewed by eLife

4. Proteomic characteristics reveal the signatures and the risks of T1 colorectal cancer metastasis to lymph nodes

   This article has 12 authors:

   1. Aojia Zhuang
   2. Aobo Zhuang
   3. Yijiao Chen
   4. Zhaoyu Qin
   5. Dexiang Zhu
   6. Li Ren
   7. Ye Wei
   8. Pengyang Zhou
   9. Xuetong Yue
   10. Fuchu He
   11. Jianmin Xu
   12. Chen Ding

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This is an important contribution to colorectal cancer research to understand how we can predict high-risk patients for recurrence. The strength of the evidence is solid and looks at a novel approach but an approach that still has opportunities to improve.

   Reviewed by eLife

5. Impact of social isolation on grey matter structure and cognitive functions: A population-based longitudinal neuroimaging study

   This article has 11 authors:

   1. Laurenz Lammer
   2. Frauke Beyer
   3. Melanie Luppa
   4. Christian Sanders
   5. Ronny Baber
   6. Christoph Engel
   7. Kerstin Wirkner
   8. Markus Loffler
   9. Steffi G Riedel-Heller
   10. Arno Villringer
   11. A Veronica Witte

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study provides an important demonstration that loneliness is associated with smaller hippocampal volume, reduced cortical thickness, and worse cognition in healthy older adults. This has theoretical or practical implications beyond a single subfield. The strength of evidence is solid given the cross-sectional and longitudinal design with a few weaknesses. With the analytical and interpretational part strengthened, this paper would be of interest to gerontologists, and dementia/cognitive aging researchers.

   Reviewed by eLife

6. Microtubule-mediated GLUT4 trafficking is disrupted in insulin-resistant skeletal muscle

   This article has 13 authors:

   1. Jonas R Knudsen
   2. Kaspar W Persson
   3. Carlos Henriquez-Olguin
   4. Zhencheng Li
   5. Nicolas Di Leo
   6. Sofie A Hesselager
   7. Steffen H Raun
   8. Janne R Hingst
   9. Raphaël Trouillon
   10. Martin Wohlwend
   11. Jørgen FP Wojtaszewski
   12. Martin AM Gijs
   13. Thomas Elbenhardt Jensen

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This paper provides strong evidence for the important point that microtubule function is required for the proper localization of Glut4 glucose transporters in an insulin responsive compartment. This membrane localization is required in turn for effective translocation of Glut4 to the muscle cell surface in response to the hormone.

   Reviewed by eLife

7. Precise temporal control of neuroblast migration through combined regulation and feedback of a Wnt receptor

   This article has 7 authors:

   1. Erik S Schild
   2. Shivam Gupta
   3. Clément Dubois
   4. Euclides E Fernandes Póvoa
   5. Marie-Anne Félix
   6. Andrew Mugler
   7. Hendrik C Korswagen

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This paper deals with an important unsolved problem in developmental biology of how cells execute their dynamics at the right time. The study combines compelling quantitative single cell and single transcript experiments with genetic perturbations and computational modelling and provides important insights into how the timing of transcription is regulated. The work would be strengthened by better integration of modeling and data.

   Reviewed by eLife

8. Projected long-term effects of colorectal cancer screening disruptions following the COVID-19 pandemic

   This article has 9 authors:

   1. Pedro Nascimento de Lima
   2. Rosita van den Puttelaar
   3. Anne I Hahn
   4. Matthias Harlass
   5. Nicholson Collier
   6. Jonathan Ozik
   7. Ann G Zauber
   8. Iris Lansdorp-Vogelaar
   9. Carolyn M Rutter

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important study uses two well-established colorectal cancer models to estimate the potential impact of disruptions in screening caused by the COVID-19 pandemic. By dividing the population into separate cohorts based on age and pre-pandemic screening status, the authors provide convincing evidence for the adverse impact of delays in screening, switching regimens, and screening discontinuation. The finding that discontinuation has a much greater impact on screening-associated gains in life expectancy than shorter-term delays or switching of regimens suggests that access-related barriers to screening resumption may lead to the worsening of current disparities.

   Reviewed by eLife

9. Differential ripple propagation along the hippocampal longitudinal axis

   This article has 2 authors:

   1. Roberto De Filippo
   2. Dietmar Schmitz

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This is an interesting study investigating the propagation dynamics of ripples recorded from the dorsal hippocampus of mice using an open-access dataset. Findings may have theoretical and practical implications for the study and manipulation of sharp-wave ripples, a main oscillatory event underlying memory consolidation. While the strength of evidence is solid and claims broadly supported, there are some points requiring additional analysis to clarify issues regarding the anatomical axes involved and to reinforce mechanistic insights.

   Reviewed by eLife

10. Integrated signaling and transcriptome analysis reveals Src family kinase individualities and novel pathways controlled by their constitutive activity

    This article has 8 authors:

    1. Nikolaos Koutras
    2. Vasileios Morfos
    3. Kyriakos Konnaris
    4. Adamantia Kouvela
    5. Athanasios-Nasir Shaukat
    6. Constantinos Stathopoulos
    7. Vassiliki Stamatopoulou
    8. Konstantina Nika

    This article has been curated by 1 group:

    • Curated by eLife

      **eLife assessment
      **
      This study presents valuable findings on how the ectopic expression of the Lck protein tyrosine kinase in Chronic Lymphocytic Leukemias (CLL) contributes to malignant transformation. The evidence supporting the claims of the authors is solid, although the use of gene editing to directly explore the functions unique to LCK in a CLL model would increase the appeal of the work.

    Reviewed by eLife