Latest preprint reviews

  1. Broca’s area, variation and taxic diversity in early Homo from Koobi Fora (Kenya)

    This article has 2 authors:
    1. Amélie Beaudet
    2. Edwin de Jager
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This important study uses the brain endocast of a ~1.9-million-year-old hominin fossil from Kenya, attributed to genus Homo, to show that the organization of the Broca's area in members of early Homo was primitive. Specifically, the prefrontal sulcal pattern in this early Homo specimen more closely resembles that of chimpanzees than of modern humans. Because Broca's area is associated with speech function, the compelling evidence from this study is relevant for understanding the timing and trajectory of evolution of speech related traits in our genus. Coupled with its potential implications for taxonomic classification, this study will be of interest to paleoanthropologists, paleontologists, archaeologists, and neuroscientists.

    Reviewed by eLife

    This article has 10 evaluationsAppears in 1 listLatest version Latest activity
  2. Association between APOL1 risk variants and the occurrence of sepsis in Black patients hospitalized with infections: a retrospective cohort study

    This article has 12 authors:
    1. Lan Jiang
    2. Ge Liu
    3. Annette Oeser
    4. Andrea Ihegword
    5. Alyson L Dickson
    6. Laura L Daniel
    7. Adriana M Hung
    8. Nancy J Cox
    9. Cecilia P Chung
    10. Wei-Qi Wei
    11. C Michael Stein
    12. Qiping Feng
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      In this valuable study, patients homozygous for both minor frequency alleles of the APOL1 gene are shown to be at significant risk for progression into sepsis after infection. The study has enrolled a significant number of subjects and provides solid results. The study addresses to infectious diseases and critical care experts and one major weakness is the lack of inclusion of non-Black patients.

    Reviewed by eLife

    This article has 5 evaluationsAppears in 1 listLatest version Latest activity
  3. Molecular portraits of colorectal cancer morphological regions

    This article has 15 authors:
    1. Eva Budinská
    2. Martina Hrivňáková
    3. Tina Catela Ivkovic
    4. Marie Madrzyk
    5. Rudolf Nenutil
    6. Beatrix Bencsiková
    7. Dagmar Al Tukmachi
    8. Michaela Ručková
    9. Lenka Zdražilová Dubská
    10. Ondřej Slabý
    11. Josef Feit
    12. Mihnea-Paul Dragomir
    13. Petra Borilova Linhartova
    14. Sabine Tejpar
    15. Vlad Popovici
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This study presents a valuable finding on the putative molecular patterns underlying characteristic morphological regions observed in colorectal cancer (CRC). The authors provide a morphological framework through which clinicians might improve the performance of molecular signatures and consequently predict the clinical response of patients with better accuracy. The evidence supporting the claims of the authors is solid. The work will be of interest to clinicians and cancer biologists working in the field of CRC.

    Reviewed by eLife

    This article has 7 evaluationsAppears in 1 listLatest version Latest activity
  4. Evaluation of surface-based hippocampal registration using ground-truth subfield definitions

    This article has 10 authors:
    1. Jordan DeKraker
    2. Nicola Palomero-Gallagher
    3. Olga Kedo
    4. Neda Ladbon-Bernasconi
    5. Sascha EA Muenzing
    6. Markus Axer
    7. Katrin Amunts
    8. Ali R Khan
    9. Boris C Bernhardt
    10. Alan C Evans
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This paper presents an important contribution to the field of hippocampal registration by introducing a novel surface-based approach that utilizes the topological and morphological features of the hippocampus for anatomical registration across individuals, rather than volumetric-based methods commonly used in the literature. The study provides compelling evidence for the efficacy of this approach using histological samples from three different datasets and offers validation of the method through comparison with traditional volumetric registration. This is significant work given the large number of studies that examine hippocampal shape, thickness, and function in large cohorts, providing strong support for the use of hippocampal unfolding methods in future studies.

    Reviewed by eLife

    This article has 12 evaluationsAppears in 1 listLatest version Latest activity
  5. Zn2+ is essential for Ca2+ oscillations in mouse eggs

    This article has 3 authors:
    1. Hiroki Akizawa
    2. Emily M Lopes
    3. Rafael A Fissore
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This manuscript reports an important series of results showing the relationship between oscillatory zinc and calcium fluctuations during egg activation and fertilization. Compelling evidence using several complimentary approaches provides further insight into the signals for proper egg activation that underpin successful fertilization and embryo development. The findings are significant because they may lead to improvements in assisted reproduction methods.

    Reviewed by eLife

    This article has 9 evaluationsAppears in 1 listLatest version Latest activity
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