eLife

Latest preprint reviews

1. Prolonged nicotine exposure reduces aversion to the drug in mice by altering nicotinic transmission in the interpeduncular nucleus

   This article has 13 authors:

   1. Sarah Mondoloni
   2. Claire Nguyen
   3. Eléonore Vicq
   4. Maria Ciscato
   5. Joachim Jehl
   6. Romain Durand-de Cuttoli
   7. Nicolas Torquet
   8. Stefania Tolu
   9. Stéphanie Pons
   10. Uwe Maskos
   11. Fabio Marti
   12. Philippe Faure
   13. Alexandre Mourot

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     In the current study, Mondoloni and colleagues reveal how a selective nicotine receptor in the interpeduncular nucleus is involved in nicotine consumption, which is an important contribution to the understanding of individual differences in drug addiction. However, the preferred hypothesis would benefit from testing in additional experimental models, metabolic assessment, and cell-type specificity.

   Reviewed by eLife

2. cAMP−EPAC−PKCε−RIM1α signaling regulates presynaptic long-term potentiation and motor learning

   This article has 15 authors:

   1. Xin-Tai Wang
   2. Lin Zhou
   3. Bin-Bin Dong
   4. Fang-Xiao Xu
   5. De-Juan Wang
   6. En-Wei Shen
   7. Xin-Yu Cai
   8. Yin Wang
   9. Na Wang
   10. Sheng-Jian Ji
   11. Wei Chen
   12. Martijn Schonewille
   13. J Julius Zhu
   14. Chris I De Zeeuw
   15. Ying Shen

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     The cerebellum plays a critical role in motor learning, but exactly which forms of synaptic plasticity contribute to learning, as well as the underlying molecular mechanisms, remain poorly understood. In this study, Wang and colleagues show that presynaptic long-term potentiation at the parallel fiber to Purkinje cell synapse is required for one form of motor learning, and involves a previously-unknown signaling cascade, where EPAC activation leads to PKCε-dependent threonine phosphorylation of RIM1α. This study provides new insights into the underlying mechanisms and functional consequences of presynaptic LTP.

   Reviewed by eLife

3. Global change in brain state during spontaneous and forced walk in Drosophila is composed of combined activity patterns of different neuron classes

   This article has 4 authors:

   1. Sophie Aimon
   2. Karen Y Cheng
   3. Julijana Gjorgjieva
   4. Ilona C Grunwald Kadow

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This paper expands on prior work by using whole-brain calcium imaging in Drosophila to examine how spontaneous and forced walking and turning affect neural activity in the brain. The measurements presented will serve as a valuable resource for the fly systems neuroscience community and suggest many testable hypotheses that may serve as the basis for future studies. Analyses of the data are solid, but conclusions drawn should be presented with more caveats. This article will be of interest to neuroscientists engaged with the central problem of how behavior modulates neural activity.

   Reviewed by eLife

4. Optical tools for visualizing and controlling human GLP-1 receptor activation with high spatiotemporal resolution

   This article has 8 authors:

   1. Loïc Duffet
   2. Elyse T Williams
   3. Andrea Gresch
   4. Simin Chen
   5. Musadiq A Bhat
   6. Dietmar Benke
   7. Nina Hartrampf
   8. Tommaso Patriarchi

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This valuable Tools and Resources paper presents new tools for investigating GLP-1 signaling: a genetically-encoded sensor constructed from a mutated GLP1R receptor as well as a caged agonist peptide. The evidence for these tools working as advertised is solid and they may be helpful for screening compounds that bind to GLP1R.

   Reviewed by eLife

5. Autoinhibited kinesin-1 adopts a hierarchical folding pattern

   This article has 8 authors:

   1. Zhenyu Tan
   2. Yang Yue
   3. Felipe Leprevost
   4. Sarah Haynes
   5. Venkatesha Basrur
   6. Alexey I Nesvizhskii
   7. Kristen J Verhey
   8. Michael A Cianfrocco

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This paper will be of significant interest to the research community working on cytoplasmic transport and microtubule motors, offering important insights into the structural arrangement of autoinhibited Kinesin-1. The paper reports a structural model of full-length kinesin-1 describing its autoinhibitory mechanism using cryo-EM, Alphafold structural predictions, cross-linking, and mass spectrometry. The data are of high quality and together offer a compelling model for how Kinesin-1 is autoinhibited, indicating that auto-inhibition does not rely on the IAK motif alone but on a more extensive intramolecular interface.

   Reviewed by eLife

6. A simple mechanism for integration of quorum sensing and cAMP signalling in Vibrio cholerae

   This article has 6 authors:

   1. Lucas M Walker
   2. James RJ Haycocks
   3. Julia C Van Kessel
   4. Triana N Dalia
   5. Ankur B Dalia
   6. David C Grainger

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This paper provides valuable new information on the mechanisms by which Vibrio cholerae integrates and responds to environmental signals. The strength of the evidence provided in support of the conclusions made and the model proposed is solid. The revision resolved many of the issues raised by the reviewers and improved the manuscript. The work is relevant for a broad audience of microbiologists interested in the mechanisms by which bacteria sense their environment.

   Reviewed by eLife

7. Rapid, DNA-induced interface swapping by DNA gyrase

   This article has 6 authors:

   1. Thomas RM Germe
   2. Natassja G Bush
   3. Victoria M Baskerville
   4. Dominik Saman
   5. Justin LP Benesch
   6. Anthony Maxwell

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This is an important study on DNA gyrase that provides further evidence for its mode of action via a double-stranded DNA break and against a recently-proposed alternative mechanism. The evidence presented is solid and is derived from state-of-the-art techniques. The work casts new light on the interactions that occur between gyrase molecules and will be of interest to biochemists and cell biologists.

   Reviewed by eLife

8. Importance of glutamine in synaptic vesicles revealed by functional studies of SLC6A17 and its mutations pathogenic for intellectual disability

   This article has 10 authors:

   1. Xiaobo Jia
   2. Jiemin Zhu
   3. Xiling Bian
   4. Sulin Liu
   5. Sihan Yu
   6. Wenjun Liang
   7. Lifen Jiang
   8. Renbo Mao
   9. Wenxia Zhang
   10. Yi Rao

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study makes a valuable contribution to our functional understanding of the atypical amino-acid transporter SLC6A177 at nerve cell synapses and the role of SLC6A17 variants in certain forms of intellectual disability. The reported evidence that disease-linked SLC6A17 variants cause behavioral abnormalities is convincing. However, corresponding molecular underpinnings, i.e. the molecular role of SLC6A17 in synapses and the functional molecular consequences of disease-related SLC6A17 variations, remain unclear because corresponding informative experimental approaches are missing - most importantly direct measurements of the transport activity of SLC6A17 in the various genetic contexts studied. This limits the robustness and validity of key mechanistic conclusions drawn from the present work.

   Reviewed by eLife

9. Targeted memory reactivation in human REM sleep elicits detectable reactivation

   This article has 4 authors:

   1. Mahmoud EA Abdellahi
   2. Anne CM Koopman
   3. Matthias S Treder
   4. Penelope A Lewis

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This valuable work in human subjects reports that sounds that were associated with specific memories during waking behaviors can trigger the reactivation of these memory representations during REM sleep. However, the evidence supporting the conclusions is currently incomplete. Still, the work has the potential to expand our understanding of memory processing during sleep.

   Reviewed by eLife

10. Large depth differences between target and flankers can increase crowding: Evidence from a multi-depth plane display

    This article has 4 authors:

    1. Samuel P Smithers
    2. Yulong Shao
    3. James Altham
    4. Peter J Bex

    This article has been curated by 1 group:

    • Curated by eLife

      eLife Assessment

      Using a novel multi-depth plan display, this study reveals a valuable finding regarding crowding - it decreases with small depth differences between the target and flankers but increases with larger depth differences. The evidence supporting this finding is convincing, although the explanation of the findings is somewhat speculative. This paper will be of interest to visual scientists, neuroscientists, and ophthalmologists, especially those working on visual crowding and depth perception.

    Reviewed by eLife