Latest preprint reviews

  1. The integration of Tgfβ and Egfr signaling programs confers the ability to lead heterogeneous collective invasion

    This article has 9 authors:
    1. Apsra Nasir
    2. Sharon Camacho
    3. Alec T. McIntosh
    4. Garrett T. Graham
    5. Raneen Rahhal
    6. Molly E. Huysman
    7. Fahda Alsharief
    8. Anna T. Riegel
    9. Gray W. Pearson
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This represents an important study that demonstrates a high degree of heterogeneity within trailblazer cells in clusters that participate in collective migration. Solid methods highlight this heterogeneity and show that in TNBC cancers, trailblazer cells are defined by vimentin (and not Keratin 14) and are dependent on both TGFbeta and EGFR signaling.

    Reviewed by eLife

    This article has 5 evaluationsAppears in 1 listLatest version Latest activity
  2. BATF relieves hepatic steatosis by inhibiting PD1 and promoting energy metabolism

    This article has 12 authors:
    1. Zhiwang Zhang
    2. Qichao Liao
    3. Tingli Pan
    4. Lin Yu
    5. Zupeng Luo
    6. Songtao Su
    7. Shi Liu
    8. Menglong Hou
    9. Yixing Li
    10. Turtushikh Damba
    11. Yunxiao Liang
    12. Lei Zhou
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This valuable study presents reports on the role of the transcription factor BATF and its target PD1 in lipid metabolism including a model of nonalcoholic fatty liver disease (NAFLD). Overall, the evidence supporting the conclusions is convincing. The work will be of interest to medical biologists working on NAFLD.

    Reviewed by eLife

    This article has 7 evaluationsAppears in 1 listLatest version Latest activity
  3. Repeatability of adaptation in sunflowers reveals that genomic regions harbouring inversions also drive adaptation in species lacking an inversion

    This article has 7 authors:
    1. Shaghayegh Soudi
    2. Mojtaba Jahani
    3. Marco Todesco
    4. Gregory L Owens
    5. Natalia Bercovich
    6. Loren H Rieseberg
    7. Sam Yeaman
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This is a valuable comparative study of local adaptation using gene-by-environment and gene-by-phenotype correlations. The analyses seemed still incomplete, as the biological take-home messages were obscured by the statistical approaches used, and it remains unclear how to best interpret the level of genome-wide convergence and in inversions. The repeatability of local adaptation across species, and the role of inversions in local adaptation, are questions of considerable empirical interest.

    Reviewed by eLife

    This article has 10 evaluationsAppears in 1 listLatest version Latest activity
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