eLife

Latest preprint reviews

1. Centriolar satellites expedite mother centriole remodeling to promote ciliogenesis

   This article has 19 authors:

   1. Emma A Hall
   2. Dhivya Kumar
   3. Suzanna L Prosser
   4. Patricia L Yeyati
   5. Vicente Herranz-Pérez
   6. Jose Manuel García-Verdugo
   7. Lorraine Rose
   8. Lisa McKie
   9. Daniel O Dodd
   10. Peter A Tennant
   11. Roly Megaw
   12. Laura C Murphy
   13. Marisa F Ferreira
   14. Graeme Grimes
   15. Lucy Williams
   16. Tooba Quidwai
   17. Laurence Pelletier
   18. Jeremy F Reiter
   19. Pleasantine Mill

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This manuscript will be of interest to centrosome and cilia cell biologists. It evaluates the in vivo and in vitro role of PCM1, and by extension, centriole satellites in ciliogenesis. The major strength of this study is the detailed characterisation of Pcm1-/- mutant mice, which reveals a role for PCM1 in biogenesis of specific types of cilia, such as motile cilia on ependymal cells. The claims are generally well supported by the data, but the mechanistic basis for the cell-type specific requirement for PCM1 in ciliogenesis remains to be fully clarified.

   Reviewed by eLife

2. Neural circuits underlying habituation of visually evoked escape behaviors in larval zebrafish

   This article has 2 authors:

   1. Haleh Fotowat
   2. Florian Engert

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     In the present study, the authors discovered the inhibitory neurons that are potentiated during the repetitive visual stimuli and control neurons that transmit looming information to evoke escape responses. Thus, the study elucidated a principle of habituation using a model vertebrate zebrafish.

   Reviewed by eLife

3. HUWE1 controls tristetraprolin proteasomal degradation by regulating its phosphorylation

   This article has 15 authors:

   1. Sara Scinicariello
   2. Adrian Soderholm
   3. Markus Schäfer
   4. Alexandra Shulkina
   5. Irene Schwartz
   6. Kathrin Hacker
   7. Rebeca Gogova
   8. Robert Kalis
   9. Kimon Froussios
   10. Valentina Budroni
   11. Annika Bestehorn
   12. Tim Clausen
   13. Pavel Kovarik
   14. Johannes Zuber
   15. Gijs A Versteeg

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     The RNA-binding protein Tristetraprolin (TPP) regulates the abundance of mRNAs encoding proinflammatory cytokines. The study by Scinicariello and collaborators examined mechanisms regulating the turnover of TTP in cultured cells and identified the ubiquitin E3 ligase HUWE1 as a regulator of TPP degradation. The conclusions are largely supported by the cellular and biochemical experiments. This paper thus implicates the HUWE1-TPP axis in regulating macrophage inflammatory responses at the post-transcriptional steps.

   Reviewed by eLife

4. Nitrogenase resurrection and the evolution of a singular enzymatic mechanism

   This article has 7 authors:

   1. Amanda K Garcia
   2. Derek F Harris
   3. Alex J Rivier
   4. Brooke M Carruthers
   5. Azul Pinochet-Barros
   6. Lance C Seefeldt
   7. Betül Kaçar

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This manuscript reports valuable findings regarding the evolution of nitrogenases through ancestral sequence reconstruction and resurrection. The results are solid and support the conclusions of the study, and highlight the historical constraints that have been acting on this enzyme. The findings will be of interest for people interested in enzyme evolution in general and particularly for those interested in the evolution of nitrogenases.

   Reviewed by eLife

5. Regulatory and coding sequences of TRNP1 co-evolve with brain size and cortical folding in mammals

   This article has 12 authors:

   1. Zane Kliesmete
   2. Lucas Esteban Wange
   3. Beate Vieth
   4. Miriam Esgleas
   5. Jessica Radmer
   6. Matthias Hülsmann
   7. Johanna Geuder
   8. Daniel Richter
   9. Mari Ohnuki
   10. Magdelena Götz
   11. Ines Hellmann
   12. Wolfgang Enard

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This is an important paper that combines comparative analysis and experimental assays to investigate the role of protein-coding and regulatory changes at TRNP1 in mammalian brain evolution. The evidence supporting a contribution of TRNP1 is convincing, although the link between protein-coding changes and trait evolution is stronger and more readily interpretable than the data on gene regulation. The work will be of interest to researchers in the areas of mammalian evolution, brain evolution, and evolutionary genetics.

   Reviewed by eLife

6. Nutrigenomic regulation of sensory plasticity

   This article has 6 authors:

   1. Hayeon Sung
   2. Anoumid Vaziri
   3. Daniel Wilinski
   4. Riley KR Woerner
   5. Lydia Freddolino
   6. Monica Dus

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important work identifies new proteins and outlines the interactions between molecular players that control diet-induced plasticity in sensory neuron function in the Drosophila taste system. The authors provide solid evidence in support of their working model and open clear avenues to follow up on downstream molecular mechanisms.

   Reviewed by eLife

7. Coarsening dynamics can explain meiotic crossover patterning in both the presence and absence of the synaptonemal complex

   This article has 3 authors:

   1. John A Fozard
   2. Chris Morgan
   3. Martin Howard

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     During meiotic prophase I, protein complexes essential for crossover recombination are distributed non-randomly along chromosomes. With mathematical modelling and based on results from super-resolution microscopy, the authors introduce a second type of coarsening of protein ensembles between chromosome axes and nucleoplasm between chromosomes and nucleoplasm to support the random distribution of the complexes in the synapsis-defective mutant. The new model is interesting and may be applied to other chromosomal events accompanied by the formation of large protein ensembles on the chromosomes. The work is of interest to colleagues studying recombination and meiosis.

   Reviewed by eLife

8. Syncytin-mediated open-ended membrane tubular connections facilitate the intercellular transfer of cargos including Cas9 protein

   This article has 2 authors:

   1. Congyan Zhang
   2. Randy Schekman

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This convincing demonstration of intercellular transfer of material and its subsequent function in the acceptor cell lends important evidence for the membrane tubular systems' role in cell communication. Importantly a fusogenic protein, syncytin, is shown to play a role in providing an open connection between the cytoplasms of both the acceptor and donor cells. The work has implications for how cells can influence each other's functions.

   Reviewed by eLife

9. A case–control study based on the National Health and Nutrition Examination Survey to evaluate the effects of human papilloma virus on bone health in women

   This article has 3 authors:

   1. Xiang Li
   2. Guangjun Jiao
   3. Yunzhen Chen

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     The study presents a useful finding on a potential link between two common public health issues, namely HPV infection and osteoporosis. The evidence supporting the claims of the authors is incomplete as a more robust statistical methodology would have strengthened the study. The work will be of interest to epidemiologists working on associations of infectious diseases with other health issues.

   Reviewed by eLife

10. Development of frequency tuning shaped by spatial cue reliability in the barn owl’s auditory midbrain

    This article has 2 authors:

    1. Keanu Shadron
    2. José Luis Peña

    This article has been curated by 1 group:

    • Curated by eLife

      eLife assessment

      This is a valuable study that uses an innovative approach to show how the statistics of sound stimulation influence neural coding in an experience-dependent fashion in the developing barn owl brain. The paper will therefore be of interest to the fields of developmental and sensory neuroscience. In its present form, however, the evidence presented to support the main claims of the paper is incomplete and could be strengthened in various ways.

    Reviewed by eLife