eLife

Latest preprint reviews

1. Telocytes regulate macrophages in periodontal disease

   This article has 6 authors:

   1. Jing Zhao
   2. Anahid A Birjandi
   3. Mohi Ahmed
   4. Yushi Redhead
   5. Jose Villagomez Olea
   6. Paul Sharpe

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     Drs Zhao and Sharpe have highlighted the role of a relatively understudied cell type, the telocyte, in periodontitis, using a mouse model. Periodontitis is a widely occurring inflammatory disease of the gums, that will eventually progress to bone resorption and teeth that are embedded less favorably and will eventually fall out. This disease is linked to many other illnesses, such as rheumatoid arthritis, cardiac disease and even Alzheimer's disease, so more in depth knowledge is needed on cell types that play a role in the progression of the disease.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #3 agreed to share their name with the authors.)

   Reviewed by eLife

2. Fibroblast-derived Hgf controls recruitment and expansion of muscle during morphogenesis of the mammalian diaphragm

   This article has 7 authors:

   1. Elizabeth M Sefton
   2. Mirialys Gallardo
   3. Claire E Tobin
   4. Brittany C Collins
   5. Mary P Colasanto
   6. Allyson J Merrell
   7. Gabrielle Kardon

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     Sefton et al. analyze how fibroblast-derived HGF integrates muscle and nerve development during morphogenesis of the mammalian diaphragm. The new findings are based on in-depth analyses of the development of the diaphragm muscle, and the role of Met and HGF in the process. The work is relevant for the understanding of muscle development, and congenital disease (hernia).

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 and Reviewer #2 agreed to share their names with the authors.)

   Reviewed by eLife

3. The mini-IDLE 3D biomimetic culture assay enables interrogation of mechanisms governing muscle stem cell quiescence and niche repopulation

   This article has 6 authors:

   1. Erik Jacques
   2. Yinni Kuang
   3. Allison P Kann
   4. Fabien Le Grand
   5. Robert S Krauss
   6. Penney M Gilbert

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This Methods paper seeks procedures evaluating the balance between muscle cell quiescence and activation. These could well permit investigations of long-standing questions in key areas of muscle function. The latter include the regulation of adult stem cell pool size and functional heterogeneities in this, as well as regulators of muscle quiescence.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #2 agreed to share their name with the authors.)

   Reviewed by eLife

4. Fine-grained functional parcellation maps of the infant cerebral cortex

   This article has 9 authors:

   1. Fan Wang
   2. Han Zhang
   3. Zhengwang Wu
   4. Dan Hu
   5. Zhen Zhou
   6. Jessica B Girault
   7. Li Wang
   8. Weili Lin
   9. Gang Li

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     There is currently a lack of available fine-grained infant-dedicated cortical parcellation maps. The present study fills an important gap in the research of infant brain development by generating an age-dependent functional brain parcellation from birth to 24 months, leveraging on the 1064 high-resolution longitudinal resting-state fMRI scans from 197 infants. These age-specific parcellation maps have the potential to facilitate scientific discoveries, comparisons, and validations in brain functional development. Moreover, the proposed method of establishing functional correspondences across individuals using functional gradient densities can also be applied to study brain changes across lifespan.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 and Reviewer #2 agreed to share their name with the authors.)

   Reviewed by eLife

5. Inhibition is a prevalent mode of activity in the neocortex around awake hippocampal ripples in mice

   This article has 5 authors:

   1. Javad Karimi Abadchi
   2. Zahra Rezaei
   3. Thomas Knöpfel
   4. Bruce L McNaughton
   5. Majid H Mohajerani

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This paper will be of interest to neurophysiologists and system neuroscientists interested in memory and more specifically in hippocampo-cortical interactions. Using a combination of imaging and electrophysiological techniques, the study characterizes neocortical activity patterns around awake hippocampal ripples. Unlike sleep ripples, cortical activity seems to be dominated by inhibition around ripples but differences between intrinsic activity and synaptic transmission highlight complex interactions in the underlying neuronal circuits and dynamics.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #3 agreed to share their name with the authors.)

   Reviewed by eLife

6. Spinosaurus is not an aquatic dinosaur

   This article has 9 authors:

   1. Paul C Sereno
   2. Nathan Myhrvold
   3. Donald M Henderson
   4. Frank E Fish
   5. Daniel Vidal
   6. Stephanie L Baumgart
   7. Tyler M Keillor
   8. Kiersten K Formoso
   9. Lauren L Conroy

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     The Cretaceous dinosaur Spinosaurus has recently drawn significant attention as it was hypothesized to be the first aquatic dinosaur, using tail-powered swimming in surface waters and at depth. In a reappraisal of the "aquatic hypothesis", new lines of evidence – including the CT-based skeletal restoration of Spinosaurus and biomechanical tests – support the alternative "semi-aquatic hypothesis". This article will be of interest to vertebrate paleontologists and functional morphologists, as well as wider academic and non-academic audiences.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1, Reviewer #2 and Reviewer #3 agreed to share their name with the authors.)

   Reviewed by eLife

7. An atrial fibrillation-associated regulatory region modulates cardiac Tbx5 levels and arrhythmia susceptibility

   This article has 8 authors:

   1. Fernanda M Bosada
   2. Karel van Duijvenboden
   3. Alexandra E Giovou
   4. Mathilde R Rivaud
   5. Jae-Sun Uhm
   6. Arie O Verkerk
   7. Bastiaan J Boukens
   8. Vincent M Christoffels

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This manuscript presents an interesting and informative study on two regulatory elements found near atrial fibrillation-associated regions and their effect on Tbx5 expression and arrhythmia susceptibility in a mouse model. The multilevel approaches and analyses are rigorous, and the conclusions are justified by the data. Tbx5 expression may be of relevance for human atrial fibrillation and disease risk in patients, and the work is of potential interest to scientists in the fields of gene dosage, gene regulation, genetic susceptibility, genetic variants and cardiovascular biology.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 and Reviewer #2 agreed to share their name with the authors.)

   Reviewed by eLife

8. Neural learning rules for generating flexible predictions and computing the successor representation

   This article has 4 authors:

   1. Ching Fang
   2. Dmitriy Aronov
   3. LF Abbott
   4. Emily L Mackevicius

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This important work provides compelling evidence for the biological plausibility of the Successor Representation (SR) algorithm. The SR is a leading computational hypothesis to explore whether neural representations are consistent with the hypothesis that the neural networks in specific brain area perform predictive computations. Establishing a biologically plausible learning rule for SR representations to form is of high importance in the field of neuroscience. This is also important for comparing the predictive ability of neural circuits with other predictive frameworks designed in machine learning.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 and Reviewer #2 agreed to share their name with the authors.)

   Reviewed by eLife

9. Individual behavioral trajectories shape whole-brain connectivity in mice

   This article has 10 authors:

   1. Jadna Bogado Lopes
   2. Anna N Senko
   3. Klaas Bahnsen
   4. Daniel Geisler
   5. Eugene Kim
   6. Michel Bernanos
   7. Diana Cash
   8. Stefan Ehrlich
   9. Anthony C Vernon
   10. Gerd Kempermann

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This is an important paper that is methodologically solid and highlights structural covariance as the neuroanatomical basis underlying individuality in genetically identical mice. The approach to individuality is very well designed, and the use of brain imaging and anatomical covariance as the underlying mechanism is well thought out. The statistical methods, while overall sound, require further justification and exploration. This paper will be of broad interest to neuroscientists, especially those working in brain plasticity or understanding unique and shared environmental influences on individuality.

   Reviewed by eLife

10. Rapid reconstruction of neural circuits using tissue expansion and light sheet microscopy

    This article has 19 authors:

    1. Joshua L Lillvis
    2. Hideo Otsuna
    3. Xiaoyu Ding
    4. Igor Pisarev
    5. Takashi Kawase
    6. Jennifer Colonell
    7. Konrad Rokicki
    8. Cristian Goina
    9. Ruixuan Gao
    10. Amy Hu
    11. Kaiyu Wang
    12. John Bogovic
    13. Daniel E Milkie
    14. Linus Meienberg
    15. Brett D Mensh
    16. Edward S Boyden
    17. Stephan Saalfeld
    18. Paul W Tillberg
    19. Barry J Dickson

    This article has been curated by 1 group:

    • Curated by eLife

      Evaluation Summary:

      This paper introduces a light microscopy pipeline for imaging and fast reconstruction of the synaptic connections of individual neuronal types in the fruit fly and for correlated investigation of circuit structure, function and behavior in the same animal. Because of its speed and accessibility, this approach enables mapping of selected neuronal circuits of multiple animals across different conditions and behavioral states, thus filling an important gap in brain research.

      (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

    Reviewed by eLife