eLife

Latest preprint reviews

1. We couldn't get details of this article at this time:
   10.1101/2021.11.08.467457

2. We couldn't get details of this article at this time:
   10.1101/2023.06.02.543421

3. We couldn't get details of this article at this time:
   10.1101/2023.06.07.543949

4. Condensin positioning at telomeres by shelterin proteins drives sister-telomere disjunction in anaphase

   This article has 13 authors:

   1. Léonard Colin
   2. Celine Reyes
   3. Julien Berthezene
   4. Laetitia Maestroni
   5. Laurent Modolo
   6. Esther Toselli
   7. Nicolas Chanard
   8. Stephane Schaak
   9. Olivier Cuvier
   10. Yannick Gachet
   11. Stephane Coulon
   12. Pascal Bernard
   13. Sylvie Tournier

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This is an important study that characterises the involvement of condensin complexes in the segregation of telomeres in fission yeast. The authors present convincing evidence to support their claims, employing a diverse range of complementary techniques. This research will be of interest to cell biologists working on chromosome biology and cell division.

   Reviewed by eLife

5. Evolution of a functionally intact but antigenically distinct DENV fusion loop

   This article has 10 authors:

   1. Rita M Meganck
   2. Deanna Zhu
   3. Stephanie Dong
   4. Lisa J Snoderly-Foster
   5. Yago R Dalben
   6. Devina Thiono
   7. Laura J White
   8. Arivianda M DeSilva
   9. Ralph S Baric
   10. Longping V Tse

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This valuable study describes engineered dengue virus variants that can be used to dissect epitope specificities in polyclonal sera, and to design candidate vaccine antigens that dampen antibody responses against undesirable epitopes. While the major claims are supported by solid evidence, experiments to distinguish the impact on antibody binding from neutralizing activities would have strengthened the study. This work will be of interest to virologists and structural biologists working on antibody responses to flaviviruses.

   Reviewed by eLife

6. FSHβ links photoperiodic signaling to seasonal reproduction in Japanese quail

   This article has 6 authors:

   1. Gaurav Majumdar
   2. Timothy A Liddle
   3. Calum Stewart
   4. Christopher J Marshall
   5. Maureen Bain
   6. Tyler Stevenson

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important article provides insights into the neural centers and hormonal modulations underlying seasonal changes associated with photoperiod-induced life-history states in birds. The physiological and transcriptomic analyses of the mediobasal hypothalamus and pituitary gland offer convincing evidence for a timing mechanism for measuring day length, which is relevant for the field of seasonal biology. The study's experiments and findings have the potential to captivate the attention of molecular and organismal endocrinologists and chronobiologists.

   Reviewed by eLife

7. Analysis of RNA processing directly from spatial transcriptomics data reveals previously unknown regulation

   This article has 2 authors:

   1. Julia Olivieri
   2. Julia Salzman

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment:

     This important study describes spatial RNA processing events by combining methods for single-cell transcriptomics data with spatial transcriptomics data. The evidence supporting the claims of the authors is solid, although the analysis could be further strengthened by including a broader range of samples as well as orthogonal validation either by experimental methods or simulated data. The work will be of general interest to researchers in the spatial transcriptomics field as well as researchers investigating alternative pre-mRNA processing across diverse tissues.

   Reviewed by eLife

8. PI(3,4,5)P3 allosteric regulation of repressor activator protein 1 controls antigenic variation in trypanosomes

   This article has 7 authors:

   1. Abdoulie O Touray
   2. Rishi Rajesh
   3. Tony Isebe
   4. Tamara Sternlieb
   5. Mira Loock
   6. Oksana Kutova
   7. Igor Cestari

   Reviewed by eLife

9. We couldn't get details of this article at this time:
   10.1101/2022.10.26.513902

10. Influenza virus transcription and progeny production are poorly correlated in single cells

    This article has 6 authors:

    1. David J Bacsik
    2. Bernadeta Dadonaite
    3. Andrew Butler
    4. Allison J Greaney
    5. Nicholas S Heaton
    6. Jesse D Bloom

    This article has been curated by 1 group:

    • Curated by eLife

      eLife assessment

      This important paper reports a novel, compelling method, based on barcoding viral genes and next-generation sequencing, to quantify both viral transcription levels and progeny virus production in influenza virus-infected cells at the single-cell level. The authors show that viral transcription and progeny virus production are unexpectedly poorly correlated, and that cells in which viral RNAs are transcribed at high levels are not necessarily those producing the most progeny virions. Because of its novelty, the study will be of interest to the broader virology community.

    Reviewed by eLife