eLife

Latest preprint reviews

1. Multifunctional requirements for ERK1/2 signaling in the development of ganglionic eminence derived glia and cortical inhibitory neurons

   This article has 14 authors:

   1. Sara J. Knowles
   2. Michael C. Holter
   3. Guohui Li
   4. George R. Bjorklund
   5. Katherina P. Rees
   6. Johan S. Martinez-Fuentes
   7. Kenji J. Nishimura
   8. Ariana E. Afshari
   9. Noah Fry
   10. April M Stafford
   11. Daniel Vogt
   12. Marco Mangone
   13. Trent Anderson
   14. Jason M. Newbern

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This is an important study on the role of the Ras/MEK/Erk signaling cascade in brain development, with both theoretical and practical implications in multiple fields. The authors reveal functional redundancy and shared function for Erk1 and Erk2 in determining medial ganglionic eminence derived glial number, and exclude a role for Erk1 and Erk2 in the regulation of GABAergic neuron number or initial specification of GABAergic identity. They combine multiple methods including Ribotags, electrophysiology, and chemogenetic stimulation using DREADDs towards comprehensive conclusions. Reviewers expressed concerns about the coherence of the findings, and about the selection of controls mouse lines. Heterozygous ERK1/2 mice are used as 'het controls' throughout the manuscript, however, reviewers felt that there was not sufficient evidence that ERK levels in heterozygous mice are similar to wildtype mice. Nevertheless, these compelling findings will be of interest to a broad readership, and especially readers interested in kinase function and neurodevelopmental syndromes.

   Reviewed by eLife

2. We couldn't get details of this article at this time:
   10.1101/2022.08.17.504249

3. We couldn't get details of this article at this time:
   10.1101/2023.03.04.531109

4. Identifying metabolic features of colorectal cancer liability using Mendelian randomization

   This article has 22 authors:

   1. Caroline Bull
   2. Emma Hazelwood
   3. Joshua A Bell
   4. Vanessa Tan
   5. Andrei-Emil Constantinescu
   6. Carolina Borges
   7. Danny Legge
   8. Kimberley Burrows
   9. Jeroen R Huyghe
   10. Hermann Brenner
   11. Sergi Castellvi-Bel
   12. Andrew T Chan
   13. Sun-Seog Kweon
   14. Loic Le Marchand
   15. Li Li
   16. Iona Cheng
   17. Rish K Pai
   18. Jane C Figueiredo
   19. Neil Murphy
   20. Marc J Gunter
   21. Nicholas J Timpson
   22. Emma E Vincent

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     The manuscript by Bull et al provides valuable information on the relationship between metabolic features, in particular different lipoproteins and fatty acids, and colorectal cancer. They use solid methods and combine different data sources to analyze forward and reverse Mendelian Randomizations that support their claims.

   Reviewed by eLife

5. We couldn't get details of this article at this time:
   10.1101/2023.06.12.544638

6. We couldn't get details of this article at this time:
   10.1101/2023.05.10.540098

7. We couldn't get details of this article at this time:
   10.1101/2023.05.03.539131

8. Understanding disruptions in cancer care to reduce increased cancer burden

   This article has 8 authors:

   1. Kia L Davis
   2. Nicole Ackermann
   3. Lisa M Klesges
   4. Nora Leahy
   5. Callie Walsh-Bailey
   6. Sarah Humble
   7. Bettina Drake
   8. Vetta L Sanders Thompson

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     The study presents patterns of cancer care disruption in southern Illinois and eastern Missouri in the summer of 2020. Survey results show factors that impact cancer care during the COVID-19 pandemic, including group differences by race. The important findings provide solid evidence about variation in cancer care disruptions and opportunities to improve return to care.

   Reviewed by eLife

9. A hierarchical model for external electrical control of an insect, accounting for inter-individual variation of muscle force properties

   This article has 3 authors:

   1. Dai Owaki
   2. Volker Dürr
   3. Josef Schmitz

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This valuable work presents new results to characterize the relationship between electrical excitation and torque generation in stick insect joints. The evidence supporting this work is a series of torque-voltage measurements across individuals. The strength of evidence is solid in supporting the outcomes, but some details of the methodology, which could potentially shed light on the sources of this variation, are missing.

   Reviewed by eLife

10. ONC201/TIC10 enhances durability of mTOR inhibitor everolimus in metastatic ER+ breast cancer

    This article has 7 authors:

    1. Elena Farmaki
    2. Aritro Nath
    3. Rena Emond
    4. Kimya L Karimi
    5. Vince K Grolmusz
    6. Patrick A Cosgrove
    7. Andrea H Bild

    This article has been curated by 1 group:

    • Curated by eLife

      eLife assessment

      This study presents a valuable finding on the combination treatment of ONC201/TIC10 with everolimus for metastatic ER+ breast cancer. The evidence supporting the claims of the authors is solid. The work will be of interest to medical biologists working on breast cancer.

    Reviewed by eLife