eLife

Latest preprint reviews

1. Rodent ultrasonic vocal interaction resolved with millimeter precision using hybrid beamforming

   This article has 3 authors:

   1. Max L Sterling
   2. Ruben Teunisse
   3. Bernhard Englitz

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study demonstrates an important method that drastically improves the precision of ultrasound localization in interacting mice. The authors present convincing evidence of the usefulness of the method for quantifying vocal behavior in various situations and demonstrate an interesting vocal dominance phenomenon between males. This tool will be of great interest to all scientists interested in vocal behavior in small animals.

   Reviewed by eLife

2. Discovery and characterization of a specific inhibitor of serine-threonine kinase cyclin-dependent kinase-like 5 (CDKL5) demonstrates role in hippocampal CA1 physiology

   This article has 19 authors:

   1. Anna Castano
   2. Margaux Silvestre
   3. Carrow I Wells
   4. Jennifer L Sanderson
   5. Carla A Ferrer
   6. Han Wee Ong
   7. Yi Lang
   8. William Richardson
   9. Josie A Silvaroli
   10. Frances M Bashore
   11. Jeffery L Smith
   12. Isabelle M Genereux
   13. Kelvin Dempster
   14. David H Drewry
   15. Navlot S Pabla
   16. Alex N Bullock
   17. Tim A Benke
   18. Sila K Ultanir
   19. Alison D Axtman

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important study reports selective CDKL5 inhibitors that may be of high interest to investigate the role of this kinase in disease (particularly, in CDKL5 deficiency disorder) and to address unsolved issues of inconsistency in the phenotypic characterization of CDKL5-deficient knockout mice. The evidence supporting the conclusions is convincing, with rigorous biochemical, in vitro and ex vivo assays. The work will be of interest to cell and medical biologists and epileptologists working in the fields of epilepsy and neural excitation.

   Reviewed by eLife

3. We couldn't get details of this article at this time:
   10.1101/2023.04.16.23288647

4. History information emerges in the cortex during learning

   This article has 5 authors:

   1. Odeya Marmor
   2. Yael Pollak
   3. Chen Doron
   4. Fritjof Helmchen
   5. Ariel Gilad

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This is important work analyzing the trial-by-trial progression of learning, and how the outcome of one trial influences cortex-wide neural responses on the next trial. However, the evidence for the central claims is incomplete because the potential confounds of slow hemodynamic effects and behavioral changes induced by the previous trial were not adequately addressed.

   Reviewed by eLife

5. A human mitofusin 2 mutation can cause mitophagic cardiomyopathy

   This article has 13 authors:

   1. Antonietta Franco
   2. Jiajia Li
   3. Daniel P Kelly
   4. Ray E Hershberger
   5. Ali J Marian
   6. Renate M Lewis
   7. Moshi Song
   8. Xiawei Dang
   9. Alina D Schmidt
   10. Mary E Mathyer
   11. John R Edwards
   12. Cristina de Guzman Strong
   13. Gerald W Dorn

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     In this paper, the authors demonstrate an interesting link between mitofusin function (MFN2) and PARKIN recruitment and mitophagy, underlying cardiomyopathy. This is a valuable finding with broad implications for understanding the mitochondrial biology as well as mechanisms involved in heart pathologies. However, the analyses are incomplete and the main conclusions are only partially supported and need to be further evidenced.

   Reviewed by eLife

6. We couldn't get details of this article at this time:
   10.1101/2023.06.04.543604

7. We couldn't get details of this article at this time:
   10.1101/2023.06.18.545466

8. Protein arginine methyltransferase 5 (Prmt5) localizes to chromatin loop anchors and modulates expression of genes at TAD boundaries during early adipogenesis

   This article has 6 authors:

   1. Sabriya A. Syed
   2. Kristina Shqillo
   3. Ankita Nand
   4. Ye Zhan
   5. Job Dekker
   6. Anthony N. Imbalzano

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     How the genome is folded three dimensionally is thought to control gene regulatory pathways during critical processes such as cellular differentiation. Using multiple assays, the authors of this important study probe topologically associated domains (TADs) and report involvement of a protein arginine methyltransferase 5 in chromatin organization and transcriptional regulation. The data gathered are generally solid and broadly support the role of this protein in organization of the adipocytic lineage, but additional control experiments would make the inferences stronger.

   Reviewed by eLife

9. We couldn't get details of this article at this time:
   10.1101/2023.03.28.534635

10. We couldn't get details of this article at this time:
    10.1101/2023.05.25.542308