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  2. Dynamic allosteric networks drive adenosine A1 receptor activation and G-protein coupling

    1. Miguel A Maria-Solano
    2. Sun Choi

    • Curated by eLife

      eLife assessment

      The authors describe the dynamics underlying allostery of the adenosine A1 receptor, providing valuable insights into the receptor's activation pathway. The enhanced sampling molecular dynamics simulations of available structural data, followed by network analysis, reveal transient conformational states and communication between functional regions. The authors carefully state the limitations of their work, including the restricted convergence of the free energy landscape and missing water-mediated hydrogen bond coordination. Collectively, they provide a convincing framework for advancing rational design strategies of specific modulators with desired modes of action.

      [Editors' note: this was originally reviewed and assessed by Biophysics Colab]

    • Curated by Biophysics Colab

      Evaluation statement (16 June 2023)

      Maria-Solano and Choi present the dynamics underlying allostery of the adenosine A1 receptor, providing valuable insights into the receptor's activation pathway. The enhanced sampling molecular dynamics simulations of available structural data, followed by network analysis, reveal transient conformational states and communication between functional regions. The authors carefully state the limitations of their work, including the restricted convergence of the free energy landscape and missing water-mediated hydrogen bond coordination. Collectively, the findings provide a convincing framework to advance rational design strategies of specific modulators with desired modes of action.

      Biophysics Colab considers this to be a convincing study and recommends it to scientists interested in the structural dynamics, allosteric pathway activations, and free energy landscapes of GPCRs.

      (This evaluation by Biophysics Colab refers to version 5 of this preprint, which has been revised in response to peer review of versions 3 and 4.)

    Reviewed by eLife, Biophysics Colab

    5 evaluationsAppears in 7 listsLatest version Latest activity

  4. DMRT1 is a testis-determining gene in rabbits and is also essential for female fertility

    1. Emilie Dujardin
    2. Marjolaine André
    3. Aurélie Dewaele
    4. Béatrice Mandon-Pépin
    5. Francis Poulat
    6. Anne Frambourg
    7. Dominique Thépot
    8. Luc Jouneau
    9. Geneviève Jolivet
    10. Eric Pailhoux
    11. Maëlle Pannetier

    • Curated by eLife

      eLife assessment

      In this important study, the rabbit was used as a non-rodent mammalian model to show that DMRT1 has a testicular promoting function as it does in humans. The experiments are meticulous and compelling, and the arguments are clear and convincing. These results may explain the gonadal dysgenesis associated with mutations in human DMRT1 and highlight the need for mammalian models other than mice to better understand the process of gonadal sex determination in humans.

    Reviewed by eLife

    9 evaluationsAppears in 1 listLatest version Latest activity

  6. Pharmacological inhibition of CLK2 activates YAP by promoting alternative splicing of AMOTL2

    1. Maya L Bulos
    2. Edyta M Grzelak
    3. Chloris Li-Ma
    4. Emily Chen
    5. Mitchell Hull
    6. Kristen A Johnson
    7. Michael J Bollong

    • Curated by eLife

      eLife assessment

      This paper reports important findings on a potent activator of the YAP pathway, demonstrating its mechanism through alternative splicing changes. The authors provide convincing evidence to support their claims. This research is of interest to biologists studying alternative splicing or the Hippo pathway, with significant implications for medical research.

    Reviewed by eLife

    9 evaluationsAppears in 1 listLatest version Latest activity

  8. Structural basis of EHEP-mediated offense against phlorotannin-induced defense from brown algae to protect akuBGL activity

    1. Xiaomei Sun
    2. Yuxin Ye
    3. Naofumi Sakurai
    4. Hang Wang
    5. Koji Kato
    6. Jian Yu
    7. Keizo Yuasa
    8. Akihiko Tsuji
    9. Min Yao

    • Curated by eLife

      eLife assessment

      This important study presents convincing evidence on how the sea slug Aplysia kurodai optimizes its digestion of brown algae, in a classical predator-prey 'arms race' at the molecular level. The experimental protein structures and enzyme assays provide support for the claims of how A. kurodai avoids inhibition by algal compounds, and also hold promise for biotechnological applications.

    Reviewed by eLife

    9 evaluationsAppears in 1 listLatest version Latest activity

  9. Characterization of tryptophan oxidation affecting D1 degradation by FtsH in the photosystem II quality control of chloroplasts

    1. Yusuke Kato
    2. Hiroshi Kuroda
    3. Shin-Ichiro Ozawa
    4. Keisuke Saito
    5. Vivek Dogra
    6. Martin Scholz
    7. Guoxian Zhang
    8. Catherine de Vitry
    9. Hiroshi Ishikita
    10. Chanhong Kim
    11. Michael Hippler
    12. Yuichiro Takahashi
    13. Wataru Sakamoto

    • Curated by eLife

      eLife assessment:

      This study adds a fundamental new perspective to a long-standing question: What controls the repair of photosystem II (PSII), a key process in maintaining and optimizing photosynthesis? The work supports a role for chemical modification in the recognition and subsequent degradation of a key protein subunit of PSII by a bacterial-type protease, suggesting that tryptophan oxidation of components of the photosynthetic apparatus after high light stress plays a critical role in initiating the PSII repair system. The evidence supporting the authors' conclusions is solid.

    Reviewed by eLife

    9 evaluationsAppears in 1 listLatest version Latest activity
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