eLife

Latest preprint reviews

1. Metabolic regulation of misfolded protein import into mitochondria

   This article has 7 authors:

   1. Yuhao Wang
   2. Linhao Ruan
   3. Jin Zhu
   4. Xi Zhang
   5. Alexander Chih-Chieh Chang
   6. Alexis Tomaszewski
   7. Rong Li

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study makes a connection between cellular metabolism and proteostasis through MAGIC, a previously proposed protein quality control pathway of clearance of cytosolic misfolded and aggregated proteins by importing into mitochondria. The authors reveal the role of Snf1, a yeast AMPK, in preventing the import of misfolded proteins to mitochondria for MAGIC controlled by the transcription factor Hap4, depending on the cellular metabolic status. The key message is important, although the evidence for physiological relevance of MAGIC for overall cellular proteostasis and its molecular regulation by Snf1 remains incomplete.

   Reviewed by eLife, Life Science Editors Foundation

2. Binding to nucleosome poises human SIRT6 for histone H3 deacetylation

   This article has 5 authors:

   1. Ekaterina Smirnova
   2. Emmanuelle Bignon
   3. Patrick Schultz
   4. Gabor Papai
   5. Adam Ben Shem

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This manuscript provides a useful reconstruction of the structure of the sirtuin-class histone deacetylase Sirt6 bound to a nucleosome based on cryo-EM observations, and additional characterization of the flexibility of the histone tails in the complex based on molecular dynamics simulations. While similar structures have recently been published elsewhere, this solid study supports the conclusions of those papers and also includes new insights into the potential dynamics of Sirt6 bound to a nucleosome, insights that help explain its substrate specificity.

   Reviewed by eLife

3. Retinal input integration in excitatory and inhibitory neurons in the mouse superior colliculus in vivo

   This article has 3 authors:

   1. Carolin Gehr
   2. Jeremie Sibille
   3. Jens Kremkow

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This valuable study contributes to understanding how retinal activity shapes the response properties of excitatory and inhibitory neurons in a major visual target, the superior colliculus. The evidence supporting the claim is convincing: the work is technically excellent yet the interpretation of these results assumes an unbiased sampling and integration of the RGC axon in the SC, a caveat pointed out by the authors. Overall, this study provides insights into the integration of visual information from the eye to the brain, and this work will be of interest to visual neuroscientists.

   Reviewed by eLife

4. Intuitive movement-based prosthesis control enables arm amputees to reach naturally in virtual reality

   This article has 7 authors:

   1. Effie Segas
   2. Sébastien Mick
   3. Vincent Leconte
   4. Océane Dubois
   5. Rémi Klotz
   6. Daniel Cattaert
   7. Aymar de Rugy

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This paper is important because of its integration of movement and contextual information to control a virtual arm for individuals with upper-limb differences. The provided evidence convincingly demonstrates the approach's feasibility for manipulating a single object shape in different orientations within a virtual environment. However, additional improvements are needed for this proof-of-concept neuro-model to fulfil practical requirements.

   Reviewed by eLife

5. An acute microglial metabolic response controls metabolism and improves memory

   This article has 20 authors:

   1. Anne Drougard
   2. Eric H Ma
   3. Vanessa Wegert
   4. Ryan Sheldon
   5. Ilaria Panzeri
   6. Naman Vatsa
   7. Stefanos Apostle
   8. Luca Fagnocchi
   9. Judith Schaf
   10. Klaus Gossens
   11. Josephine Völker
   12. Shengru Pang
   13. Anna Bremser
   14. Erez Dror
   15. Francesca Giacona
   16. Sagar Sagar
   17. Michael X Henderson
   18. Marco Prinz
   19. Russell G Jones
   20. John Andrew Pospisilik

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important study demonstrates a link between an acute high fat diet, microglial metabolism and improved higher cognitive function. The evidence supporting the proposed mechanism in vivo is incomplete at this stage due to non-trivial technical limitations but the authors provide convincing in vitro metabolic characterization of primary microglia cultures to support the model. This work will be of interest to a broad audience in the field of neuroscience, metabolism, and immunology.

   Reviewed by eLife

6. Integrin β4 promotes DNA damage-related drug resistance in triple-negative breast cancer via TNFAIP2/IQGAP1/RAC1

   This article has 11 authors:

   1. Huan Fang
   2. Wenlong Ren
   3. Qiuxia Cui
   4. Huichun Liang
   5. Chuanyu Yang
   6. Wenjing Liu
   7. Xinye Wang
   8. Xue Liu
   9. Yujie Shi
   10. Jing Feng
   11. Ceshi Chen

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study presents a rather valuable finding that IQGAP1 interacts with TNFAIP2, which activates Rac1 to promote drug resistance in TNBC. The evidence supporting the claims of the authors is quite solid. The work will be of interest to scientists working on breast cancer.

   Reviewed by eLife

7. Mouse gingival single-cell transcriptomic atlas identified a novel fibroblast subpopulation activated to guide oral barrier immunity in periodontitis

   This article has 5 authors:

   1. Takeru Kondo
   2. Annie Gleason
   3. Hiroko Okawa
   4. Akishige Hokugo
   5. Ichiro Nishimura

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     The findings of this article provide valuable information on the changes of cell clusters induced by chronic periodontitis. The observation of a new fibroblast subpopulation, named AG fibroblasts, is interesting, and the strength of evidence presented is solid.

   Reviewed by eLife

8. De novo fatty-acid synthesis protects invariant NKT cells from cell death, thereby promoting their homeostasis and pathogenic roles in airway hyperresponsiveness

   This article has 11 authors:

   1. Jaemoon Koh
   2. Yeon Duk Woo
   3. Hyun Jung Yoo
   4. Jun-Pyo Choi
   5. Sae Hoon Kim
   6. Yoon-Seok Chang
   7. Kyeong Cheon Jung
   8. Ji Hyung Kim
   9. Yoon Kyung Jeon
   10. Hye Young Kim
   11. Doo Hyun Chung

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     The study's results offer a fundamental insight into how ACC1-mediated fatty-acid synthesis affects the survival and pathogenicity of iNKT cells in allergic asthma. The inclusion of mouse models, involving genetic adjustments and reconstitution experiments, along with the disparities found in iNKT cells between allergic asthma patients and control subjects in human studies, adds compelling evidence that substantiates these findings.

   Reviewed by eLife

9. Adenylnucleotide-mediated binding of the PII-like protein SbtB contributes to controlling activity of the cyanobacterial bicarbonate transporter SbtA

   This article has 6 authors:

   1. Britta Förster
   2. Bratati Mukherjee
   3. Loraine M. Rourke
   4. Joe A. Kaczmarski
   5. Colin J. Jackson
   6. G. Dean Price

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study is of fundamental importance, addressing the regulation of the carbon concentrating mechanism in cyanobacteria. It is a well-controlled investigation of low affinity regulatory binding of small molecules, processes that are typically difficult to examine. The work provides compelling evidence that the adenylate pool, rather than any single metabolite, regulates a key bicarbonate transporter (SbtA) to provide efficient bicarbonate supply while preventing futile cycling that can result from escape of unfixed CO2.

   Reviewed by eLife

10. The yeast RNA methylation complex consists of conserved yet reconfigured components with m6A-dependent and independent roles

    This article has 16 authors:

    1. Imke Ensinck
    2. Alexander Maman
    3. Waleed S Albihlal
    4. Michelangelo Lassandro
    5. Giulia Salzano
    6. Theodora Sideri
    7. Steven A Howell
    8. Enrica Calvani
    9. Harshil Patel
    10. Guy Bushkin
    11. Markus Ralser
    12. Ambrosius P Snijders
    13. Mark Skehel
    14. Ana Casañal
    15. Schraga Schwartz
    16. Folkert J van Werven

    This article has been curated by 1 group:

    • Curated by eLife

      eLife assessment

      This fundamental study identifies the components of the N6-methyladenosine methyltransferase complexes in yeasts, with major differences with the same complexes in mammals and flies. The evidence supporting the conclusions is convincing, with rigorous high-throughput sequencing approaches and detailed functional analysis. This work will be of broad interest to colleagues in the RNA modification and meiosis fields.

    Reviewed by eLife