eLife

Latest preprint reviews

1. Force propagation between epithelial cells depends on active coupling and mechano-structural polarization

   This article has 13 authors:

   1. Artur Ruppel
   2. Dennis Wörthmüller
   3. Vladimir Misiak
   4. Manasi Kelkar
   5. Irène Wang
   6. Philippe Moreau
   7. Adrien Méry
   8. Jean Révilloud
   9. Guillaume Charras
   10. Giovanni Cappello
   11. Thomas Boudou
   12. Ulrich S Schwarz
   13. Martial Balland

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     Using surface micropatterning, optical activation, and theoretical analysis, the authors provide compelling evidence that adjacent cells actively propagate mechanical stress in epithelial tissues. The response of the receiver cell is active and enhanced when the principal stress direction is perpendicular to the orientation of actin fibers. This work is important and a must-read for everybody wanting to understand tissue mechanics.

   Reviewed by eLife

2. Neural circuit-wide analysis of changes to gene expression during deafening-induced birdsong destabilization

   This article has 5 authors:

   1. Bradley M Colquitt
   2. Kelly Li
   3. Foad Green
   4. Robert Veline
   5. Michael S Brainard

   This article has been curated by 1 group:

   • Curated by eLife

     **eLife assessment
     **
     This is an important study that uses the song system in a bird model to understand the transcriptional mechanisms underlying neuronal adaptations to sensory deprivation. The manuscript offers compelling data in support of their hypothesis that these transcriptional changes are related to song plasticity. The work will be of interest to biologists who study neuronal plasticity mechanisms.

   Reviewed by eLife

3. How inhibitory and excitatory inputs gate output of the inferior olive

   This article has 6 authors:

   1. Sebastián Loyola
   2. Tycho M Hoogland
   3. Hugo Hoedemaker
   4. Vincenzo Romano
   5. Mario Negrello
   6. Chris I De Zeeuw

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     Inferior olivary neurons drive complex spiking activity in Purkinje neurons of the cerebellar cortex, ultimately playing critical roles in controlling motor coordination and plasticity. Using transgenic mice or optogenetic techniques to independently control a major excitatory and inhibitory pathway to the inferior olive, the authors show that the probability and phase of olivary neuron output depend critically on the relative timing of excitation and inhibitory inputs. Network models predict that appropriately timed excitatory and inhibitory input patterns efficiently synchronize larger clusters of inferior olivary neurons, raising the possibility that input timing can gate the output of the motor commands. These valuable findings have the potential to impact the field's understanding of sensorimotor processing, but the strength of evidence is currently incomplete.

   Reviewed by eLife

4. PTH regulates osteogenesis and suppresses adipogenesis through Zfp467 in a feed-forward, PTH1R-cyclic AMP-dependent manner

   This article has 9 authors:

   1. Hanghang Liu
   2. Akane Wada
   3. Isabella Le
   4. Phuong T Le
   5. Andrew WF Lee
   6. Jun Zhou
   7. Francesca Gori
   8. Roland Baron
   9. Clifford J Rosen

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     The study provides evidence that the hormone PTH increases bone mass by, at least in part, regulating the factor Zfp467. In turn, Zfp67 controls expression of the receptor for PTH, thus creating a feedback loop that overall augments bone mass. The findings are novel and of potential great interest. Overall, the study is of interest to a broad audience and significant as it unveils a novel feedback loop involving PTH, a critical endocrine regulator of calcium, phosphate, and bone mass.

   Reviewed by eLife

5. A high-throughput cytotoxicity screening platform reveals agr-independent mutations in bacteraemia-associated Staphylococcus aureus that promote intracellular persistence

   This article has 16 authors:

   1. Abderrahman Hachani
   2. Stefano G Giulieri
   3. Romain Guérillot
   4. Calum J Walsh
   5. Marion Herisse
   6. Ye Mon Soe
   7. Sarah L Baines
   8. David R Thomas
   9. Shane Doris Cheung
   10. Ashleigh S Hayes
   11. Ellie Cho
   12. Hayley J Newton
   13. Sacha Pidot
   14. Ruth C Massey
   15. Benjamin P Howden
   16. Timothy P Stinear

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This paper describes a new method to investigate Staphylococcus aureus intracellular virulence that has produced important insights into the mechanisms of staphylococcal pathogenesis. The results are convincing and the methodology is state-of-the-art. This paper will be of interest to scientists studying microbial intracellular pathogenesis and cell biology.

   Reviewed by eLife

6. Genetic architecture of heart mitochondrial proteome influencing cardiac hypertrophy

   This article has 22 authors:

   1. Karthickeyan Chella Krishnan
   2. Elie-Julien El Hachem
   3. Mark P Keller
   4. Sanjeet G Patel
   5. Luke Carroll
   6. Alexis Diaz Vegas
   7. Isabela Gerdes Gyuricza
   8. Christine Light
   9. Yang Cao
   10. Calvin Pan
   11. Karolina Elżbieta Kaczor-Urbanowicz
   12. Varun Shravah
   13. Diana Anum
   14. Matteo Pellegrini
   15. Chi Fung Lee
   16. Marcus M Seldin
   17. Nadia A Rosenthal
   18. Gary A Churchill
   19. Alan D Attie
   20. Benjamin Parker
   21. David E James
   22. Aldons J Lusis

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This paper demonstrates the genetic architecture of heart mitochondrial proteome that influences cardiac hypertrophy, using a panel of inbred mouse strains called the Hybrid Mouse Diversity Panel (HMDP). The HDM panel is a very powerful tool to study the genetic basis of various physiological and pathological processes in mice. The authors have used this panel extensively before, and in this paper, they extend their proteomic studies to demonstrate the genetic basis of cardiac hypertrophy. The studies will allow us to better understand the genetics of hypertrophic cardiomyopathy.

   Reviewed by eLife

7. Widespread mermithid nematode parasitism of Cretaceous insects

   This article has 6 authors:

   1. Cihang Luo
   2. George O Poinar
   3. Chunpeng Xu
   4. De Zhuo
   5. Edmund A Jarzembowski
   6. Bo Wang

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important study greatly expands our knowledge of the fossil record of Mermithid nematodes, modern members of which are ecologically important parasitoids of arthropods, annelids and mollusks today. The most important finding, convincingly presented, is that mermithids parasitized a number of insect clades in the Cretaceous that they are not known to infect today or in Cenozoic amber. The evidence for a shift in exploited hosts from heterometabolous insects in the Cretaceous to holometabolous ones in the Miocene is solid but could be made exceptional by adding a small quantitative analysis with confidence intervals and bar plots from the data already compiled in the supplementary material; potential collection bias should be addressed as well.

   Reviewed by eLife

8. Large-scale electrophysiology and deep learning reveal distorted neural signal dynamics after hearing loss

   This article has 5 authors:

   1. Shievanie Sabesan
   2. Andreas Fragner
   3. Ciaran Bench
   4. Fotios Drakopoulos
   5. Nicholas A Lesica

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This fundamental work uses deep neural networks to simulate activity evoked by a wide range of stimuli and demonstrates systematic differences in latent population representations between hearing-impaired and normal-hearing animals that are consistent with impaired representations of speech in noise. While the evidence supporting the conclusions is compelling, additional analyses would facilitate the generalizability of the neural-network approach. The research will be of interest to auditory neuroscientists and computational scientists.

   Reviewed by eLife

9. Comparable in vivo joint kinematics between self-reported stable and unstable knees after TKA can be explained by muscular adaptation strategies: A retrospective observational study

   This article has 7 authors:

   1. Longfeng Rao
   2. Nils Horn
   3. Nadja Meister
   4. Stefan Preiss
   5. William R Taylor
   6. Alessandro Santuz
   7. Pascal Schütz

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This manuscript provides valuable data gathered using a new video fluoroscopy method by which movements of artificial joints can be visualized in real time. These solid data add to the understanding of the links between symptoms of unstable joints after total knee replacement and actual joint instability. The paper should be of interest to those who study biomechanics after total joint replacement.

   Reviewed by eLife

10. Sexual dimorphism in obesity is governed by RELMα regulation of adipose macrophages and eosinophils

    This article has 9 authors:

    1. Jiang Li
    2. Rebecca E Ruggiero-Ruff
    3. Yuxin He
    4. Xinru Qiu
    5. Nancy Lainez
    6. Pedro Villa
    7. Adam Godzik
    8. Djurdjica Coss
    9. Meera G Nair

    This article has been curated by 1 group:

    • Curated by eLife

      eLife assessment

      In this study, Li and al describe valuable insights into the mechanisms underlying sex-differences diet-induced obesity in mice, with a role of macrophage-derived RELMa secretion in female-specific protection. They provide solid evidence for the impact of RELMa signaling in eosinophil recruitment for diet-induced obesity protection in female mice. Single-cell RNA-seq analysis of the stromal vascular fraction of control and RELMa deficient animals methods were used to investigate molecular mechanisms underlying the protection as a powerful method, although the analysis of this data is difficult to evaluate with incomplete methodological information.

    Reviewed by eLife