eLife

Latest preprint reviews

1. A single-cell atlas depicting the cellular and molecular features in human anterior cruciate ligamental degeneration: A single cell combined spatial transcriptomics study

   This article has 7 authors:

   1. Runze Yang
   2. Tianhao Xu
   3. Lei Zhang
   4. Minghao Ge
   5. Liwei Yan
   6. Jian Li
   7. Weili Fu

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     The creation of a single-cell atlas of normal and degenerative human anterior cruciate ligament (ACL) tissues using a single-cell RNA sequencing method is an important approach to understanding the pathological mechanisms of ACL degeneration. The data of this study showed the existence of fibroblasts, endothelial cells, pericytes, and immune cells in healthy ACL, and their ratios altered in the degenerative ACL, mainly exhibited as an increase in fibroblasts and immune cells. The data analysis suggests that alterations of spatial transcriptome and changes in gene expression and signaling pathways may contribute to ACL degeneration.

   Reviewed by eLife

2. Histone deacetylase 6 inhibition promotes microtubule acetylation and facilitates autophagosome–lysosome fusion in dystrophin‐deficient mdx mice

   This article has 5 authors:

   1. Akanksha Agrawal
   2. Erin L. Clayton
   3. Courtney L. Cavazos
   4. Benjamin A. Clayton
   5. George G. Rodney

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important study pinpoints nitrite oxide synthase 2 activity and decreased microtubule acetylation as distinct regulators of altered autophagic flux that may contribute to pathogenesis in a mouse model of Duchenne muscular dystrophy. While most of the evidence to support these claims is convincing, the claim that autophagy is improved with increased microtubule acetylation is incompletely supported. This work may be of broad interest to muscle biologists and has translational potential for the treatment of Duchenne muscular dystrophy.

   Reviewed by eLife

3. The impact of COVID-19 on cancer screening and treatment in older adults: The Multiethnic Cohort Study

   This article has 6 authors:

   1. Victoria P Mak
   2. Kami White
   3. Lynne R Wilkens
   4. Iona Cheng
   5. Christopher A Haiman
   6. Loic Le Marchand

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     The authors used the Multiethnic Cohort (MEC) study to study how COVID-19 impacted access to cancer screenings and treatment. This study's important findings served to identify key factors associated with cancer-related screening and healthcare-seeking during the pandemic. This investigation provides solid evidence to inform future policies, particularly in older and vulnerable populations.

   Reviewed by eLife

4. Associations of four biological age markers with child development: A multi-omic analysis in the European HELIX cohort

   This article has 20 authors:

   1. Oliver Robinson
   2. ChungHo E Lau
   3. Sungyeon Joo
   4. Sandra Andrusaityte
   5. Eva Borras
   6. Paula de Prado-Bert
   7. Lida Chatzi
   8. Hector C Keun
   9. Regina Grazuleviciene
   10. Kristine B Gutzkow
   11. Lea Maitre
   12. Dries S Martens
   13. Eduard Sabido
   14. Valérie Siroux
   15. Jose Urquiza
   16. Marina Vafeiadi
   17. John Wright
   18. Tim S Nawrot
   19. Mariona Bustamante
   20. Martine Vrijheid

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This is an important study that examined multiple biological age measures in children, which has been lacking in literature. The findings of this study provided convincing evidence to interpret and understand the aging and developmental processes in children.

   Reviewed by eLife

5. Comparative single-cell profiling reveals distinct cardiac resident macrophages essential for zebrafish heart regeneration

   This article has 9 authors:

   1. Ke-Hsuan Wei
   2. I-Ting Lin
   3. Kaushik Chowdhury
   4. Khai Lone Lim
   5. Kuan-Ting Liu
   6. Tai-Ming Ko
   7. Yao-Ming Chang
   8. Kai-Chien Yang
   9. Shih-Lei (Ben) Lai

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     The authors analyze changes in the gene expression of different immune cells during heart regeneration using single-cell RNA-sequencing and assess changes upon drug treatment that depletes macrophages. They find that drug treatment affects the gene expression profiles of different and abundance of immune cells. The work provides a wealth of gene expression data and a nice analysis supporting immune cell interactions during heart regeneration, so will be a useful resource.

   Reviewed by eLife

6. Tracing the development and lifespan change of population-level structural asymmetry in the cerebral cortex

   This article has 14 authors:

   1. James M Roe
   2. Didac Vidal-Pineiro
   3. Inge K Amlien
   4. Mengyu Pan
   5. Markus H Sneve
   6. Michel Thiebaut de Schotten
   7. Patrick Friedrich
   8. Zhiqiang Sha
   9. Clyde Francks
   10. Espen M Eilertsen
   11. Yunpeng Wang
   12. Kristine B Walhovd
   13. Anders M Fjell
   14. René Westerhausen

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     Roe et al. provide a large-sample analysis of hemispheric lateralisation in brain structure, synthesising local cortical thickness and surface area data from 7 different datasets. The study provides a rich descriptive catalogue of phenomena related to hemispheric anatomical asymmetries. These results are convincing and will prove an important point of reference to neuroscientists who might want to compare their own future results to the ones from this large and varied data set.

   Reviewed by eLife

7. Mechanotransductive feedback control of endothelial cell motility and vascular morphogenesis

   This article has 14 authors:

   1. Devon E Mason
   2. Paula Camacho
   3. Megan E Goeckel
   4. Brendan R Tobin
   5. Sebastián L Vega
   6. Pei-Hsun Wu
   7. Dymonn Johnson
   8. Su-Jin Heo
   9. Denis Wirtz
   10. Jason A Burdick
   11. Levi Wood
   12. Brian Y Chow
   13. Amber N Stratman
   14. Joel D Boerckel

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This fundamental study substantially advances our current understanding of mechanotransduction within endothelial cells. The evidence provided by the authors in the revised manuscript is compelling, which taken together, provides strong support for the authors' major findings. The work will be of broad interest to cell biologists and vascular biologists.

   Reviewed by eLife

8. Self-formation of concentric zones of telencephalic and ocular tissues and directional retinal ganglion cell axons

   This article has 5 authors:

   1. Wei Liu
   2. Rupendra Shrestha
   3. Albert Lowe
   4. Xusheng Zhang
   5. Ludovic Spaeth

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     In this important study, the authors present a human telencephalon-eye organoid model that exhibits remarkable pathfinding and growth of retinal ganglion cell (RGC) axons. The identification of cell-surface markers for RGCs could have value for understanding the molecular mechanisms involved in RGC axon development and regeneration. The strength of evidence is compelling for future studies to investigate RGC neurite outgrowth and brain-eye connectivity in humans.

   Reviewed by eLife

9. Coevolution of the CDCA7-HELLS ICF-related nucleosome remodeling complex and DNA methyltransferases

   This article has 5 authors:

   1. Hironori Funabiki
   2. Isabel E Wassing
   3. Qingyuan Jia
   4. Ji-Dung Luo
   5. Thomas Carroll

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important manuscript reveals signatures of co-evolution of two nucleosome remodeling factors, Lsh/HELLS and CDCA7, which are involved in the regulation of eukaryotic DNA methylation. The results suggest that the roles for the two factors in DNA methylation maintenance pathways can be traced back to the last eukaryotic common ancestor and that the CDC7A-HELLS-DNMT axis shaped the evolutionary retention of DNA methylation in eukaryotes. The solid evolutionary analyses form a strong basis for experimental follow-up studies. The work should be of interest to colleagues in the fields of evolutionary biology, chromatin biology and genome biology.

   Reviewed by eLife

10. Hsf1 and the molecular chaperone Hsp90 support a ‘rewiring stress response’ leading to an adaptive cell size increase in chronic stress

    This article has 8 authors:

    1. Samarpan Maiti
    2. Kaushik Bhattacharya
    3. Diana Wider
    4. Dina Hany
    5. Olesya Panasenko
    6. Lilia Bernasconi
    7. Nicolas Hulo
    8. Didier Picard

    This article has been curated by 1 group:

    • Curated by eLife

      eLife assessment

      This important study describes the coordinated regulation of cellular size and protein translation in response to chronic stress as an adaptive mechanism, termed the 'rewiring stress response' regulated by the heat shock response. The evidence supporting this conclusion is solid, utilizing diverse methods to monitor and manipulate cell size and evaluate stress resistance. The study could be strengthened by the inclusion of more experiments focused on defining the mechanistic basis of this coordination and broadening the scope of the specific role of the 'rewiring stress response' across different chronic cellular stresses. This work will be of broad interest to researchers interested in diverse fields including cellular proteostasis, stress-responsive signaling, and aging and senescence.

    Reviewed by eLife