eLife

Latest preprint reviews

1. Exposure to high-sugar diet induces transgenerational changes in sweet sensitivity and feeding behavior via H3K27me3 reprogramming

   This article has 7 authors:

   1. Jie Yang
   2. Ruijun Tang
   3. Shiye Chen
   4. Yinan Chen
   5. Kai Yuan
   6. Rui Huang
   7. Liming Wang

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study presents an important finding that high-sugar diet-induced behavioral changes can be transmitted to the offspring through the maternal germline. Using genetic and molecular biology approaches in the fruit fly model, the authors argue that this Lamarckian inheritance is mediated by germline-inherited chromatin and is regulated by the general activity of a histone methylase, and H3K27me3 modification plays a critical role in this transgenerational effect. The behavioral data are convincing, while the underlying molecular and neural mechanisms need to be strengthened. The work will be of great interest to behaviorists and epigeneticist.

   Reviewed by eLife

2. Structure-based learning to model complex protein-DNA interactions and transcription-factor co-operativity in cis -regulatory elements

   This article has 12 authors:

   1. O Fornes
   2. A Meseguer
   3. J Aguirre-Plans
   4. P Gohl
   5. PM Bota
   6. R Molina-Fernández
   7. J Bonet
   8. AC Hernandez
   9. F Pegenaute
   10. O Gallego
   11. N Fernandez-Fuentes
   12. B Oliva

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This valuable study describes the development of a new structure-based learning approach to predict transcription binding specificity and its application in the modeling of regulatory complexes in cis-regulatory modules. The authors developed a structure-based learning approach to predict TF binding features and model the regulatory complex(es) in cis-regulatory modules, integrating experimental knowledge of structures of TF-DNA complexes and high-throughput TF-DNA interactions. The validation presented by the authors is currently incomplete, with a large variability in the performance of the method on the different TF families tested.

   Reviewed by eLife

3. We couldn't get details of this article at this time:
   10.1101/2023.02.22.529544

4. PerTurboID, a targeted in situ method reveals the impact of kinase deletion on its local protein environment in the cytoadhesion complex of malaria-causing parasites

   This article has 5 authors:

   1. Heledd Davies
   2. Hugo Belda
   3. Malgorzata Broncel
   4. Jill Dalimot
   5. Moritz Treeck

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important study combines conditional mutagenesis with proximity labeling to evaluate alterations in a sub-cellular proteome upon a perturbing event. The approach is applied to the deletion of a kinase involved in trafficking of adhesins to the malaria parasite-infected erythrocyte surface and the evidence supporting the conclusions is compelling. The work will be of broad interest to cell biologists and biochemists.

   Reviewed by eLife

5. We couldn't get details of this article at this time:
   10.1101/2023.06.28.546966

6. Apoptotic signaling clears engineered Salmonella in an organ-specific manner

   This article has 10 authors:

   1. Taylor J Abele
   2. Zachary P Billman
   3. Lupeng Li
   4. Carissa K Harvest
   5. Alexia K Bryan
   6. Gabrielle R Magalski
   7. Joseph P Lopez
   8. Heather N Larson
   9. Xiao-Ming Yin
   10. Edward A Miao

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     Host cell death is an effective strategy to protect against infection, and is believed to function primarily by the elimination of the intracellular niche for pathogen replication. Abele and colleagues address an important question: does the mode of cell death affect its effectiveness in pathogen clearance? Consistent with prior observations, the authors provide compelling new evidence that the answer can depend on the cell type and/or tissue involved.

   Reviewed by eLife

7. We couldn't get details of this article at this time:
   10.1101/2023.06.05.543680

8. Per-ischemic changes in penumbral blood supply and its microscopic distribution

   This article has 7 authors:

   1. Nina K. Iversen
   2. Eugenio Gutierréz Jimenéz
   3. Peter Mondrup Rasmussen
   4. Hugo Angelys
   5. Irene Klærke Mikkelsen
   6. Tristan R. Hollyer
   7. Leif Østergaard

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This manuscript provides a useful characterization of penumbral microvascular flow disturbances over the first hours after ischemia onset in a rat model of middle cerebral artery occlusion. This work suggests that there are microscopic changes (including directionality of capillary blood flow and formation of capillary stalls) during the peri-ischemic timeframe but the data are incomplete and not sufficient to support the claims.

   Reviewed by eLife

9. We couldn't get details of this article at this time:
   10.1101/2023.06.05.543445

10. We couldn't get details of this article at this time:
    10.1101/2023.05.30.542885