eLife

Latest preprint reviews

1. High-resolution volumetric imaging constrains compartmental models to explore synaptic integration and temporal processing by cochlear nucleus globular bushy cells

   This article has 8 authors:

   1. George A Spirou
   2. Matthew Kersting
   3. Sean Carr
   4. Bayan Razzaq
   5. Carolyna Yamamoto Alves Pinto
   6. Mariah Dawson
   7. Mark H Ellisman
   8. Paul B Manis

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This manuscript provides a structural analysis of bushy cells in the mouse cochlear nucleus. These neurons receive a large synaptic contact from the auditory nerve termed an endbulb that preserves the temporal information present in the auditory nerve and are key elements of binaural sound localization circuits. The analysis combines volume electron microscopy techniques with computational models to predict heterogeneous bushy cell responses. The analysis takes morphological analysis of bushy cells to a new level, and the modeling is well done.

   Reviewed by eLife

2. Interaction between Teneurin-2 and microtubules via EB proteins provides a platform for GABAA receptor exocytosis

   This article has 7 authors:

   1. Sotaro Ichinose
   2. Yoshihiro Susuki
   3. Nobutake Hosoi
   4. Ryosuke Kaneko
   5. Mizuho Ebihara
   6. Hirokazu Hirai
   7. Hirohide Iwasaki

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This potentially important paper investigates the mechanisms that contribute to building inhibitory synapses through differential protein release from microtubules. The experiments are generally designed well, but the evidence supporting the conclusions is incomplete. This manuscript will be of interest to neuroscientists and cell biologists interested in intracellular trafficking and synapse maturation.

   Reviewed by eLife

3. Amelioration of non-alcoholic fatty liver disease by targeting adhesion G protein-coupled receptor F1 (Adgrf1)

   This article has 12 authors:

   1. Mengyao Wu
   2. Tak-Ho Lo
   3. Liping Li
   4. Jia Sun
   5. Chujun Deng
   6. Ka-Ying Chan
   7. Xiang Li
   8. Steve Ting-Yuan Yeh
   9. Jimmy Tsz Hang Lee
   10. Pauline Po Yee Lui
   11. Aimin Xu
   12. Chi-Ming Wong

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     These valuable findings presented by Wu et al. advance our understanding in novel cell signaling regulators of hepatic metabolism. The evidence supporting these conclusions are solid, utilizing in vivo and in vitro gain and loss of function studies. These work will be of interest to biologists working in the field of hepatic steatosis.

   Reviewed by eLife

4. FAM76B regulates NF-κB-mediated inflammatory pathway by influencing the translocation of hnRNPA2B1

   This article has 9 authors:

   1. Dongyang Wang
   2. Xiaojing Zheng
   3. Lihong Chai
   4. Junli Zhao
   5. Jiuling Zhu
   6. Yanqing Li
   7. Peiyan Yang
   8. Qinwen Mao
   9. Haibin Xia

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     The paper provides important insight into the function of FAM76B protein as a regulator of inflammation. The knockout/overexpression data are solid, however, the mechanism of regulation and the role of FAM76B in neurodegeneration is incomplete and requires additional experimentation. The work will be of interest to researchers studying inflammation, particularly neuroinflammation.

   Reviewed by eLife

5. Aerobic exercise reverses aging-induced depth-dependent decline in cerebral microcirculation

   This article has 18 authors:

   1. Paul Shin
   2. Qi Pian
   3. Hidehiro Ishikawa
   4. Gen Hamanaka
   5. Emiri T Mandeville
   6. Shuzhen Guo
   7. Buyin Fu
   8. Mohammed Alfadhel
   9. Srinivasa Rao Allu
   10. Ikbal Şencan-Eğilmez
   11. Baoqiang Li
   12. Chongzhao Ran
   13. Sergei A Vinogradov
   14. Cenk Ayata
   15. Eng Lo
   16. Ken Arai
   17. Anna Devor
   18. Sava Sakadžić

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important study shows that exercise improves cerebrovascular function during aging using convincing methods, the authors show that aerobic exercise reverses aging-induced deficits in microvascular perfusion and oxygenation and potentially improves short-term memory. This work will be of broad interest to researchers and clinicians studying vascular function, age-related cognitive decline, and the effects of aerobic exercise on reversing age-related dysfunction.

   Reviewed by eLife

6. Biallelic variants in MAD2L1BP (p31comet) cause female infertility characterized by oocyte maturation arrest

   This article has 17 authors:

   1. Lingli Huang
   2. Wenqing Li
   3. Xingxing Dai
   4. Shuai Zhao
   5. Bo Xu
   6. Fengsong Wang
   7. Ren-Tao Jin
   8. Lihua Luo
   9. Limin Wu
   10. Xue Jiang
   11. Yu Cheng
   12. Jiaqi Zou
   13. Caoling Xu
   14. Xianhong Tong
   15. Heng-Yu Fan
   16. Han Zhao
   17. Jianqiang Bao

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This valuable study identifies three independent patient mutations in MAD2L1BP (p31 comet) that cause infertility. Consistent with the known functions of p31 comet, solid experiments in mouse oocytes imply that infertility could be caused by a failure to silence the spindle assembly checkpoint, though the mechanism was not determined. Although the sample size is small, a rescue experiment in human oocytes promises the potential for therapy.

   Reviewed by eLife

7. A computational method for predicting the most likely evolutionary trajectories in the stepwise accumulation of resistance mutations

   This article has 5 authors:

   1. Ruth Charlotte Eccleston
   2. Emilia Manko
   3. Susana Campino
   4. Taane G Clark
   5. Nicholas Furnham

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This report is a useful demonstration of how to predict the mutational pathways to antimicrobial resistance (AMR) emergence, particularly in the enzyme DHFR (dihydrofolate reductase). The methodology is overall solid but some of the claims are only partially supported. The work will be of interest to microbiologists and evolutionary biologists interested in antimicrobial resistance and its population genetics dynamic.

   Reviewed by eLife

8. Determining growth rates from bright-field images of budding cells through identifying overlaps

   This article has 6 authors:

   1. Julian MJ Pietsch
   2. Alán F Muñoz
   3. Diane-Yayra A Adjavon
   4. Iseabail Farquhar
   5. Ivan BN Clark
   6. Peter S Swain

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     In this interesting manuscript, Pietsch et al. develop innovative machine learning approaches for automated analysis of budding yeast live-cell imaging data obtained with a dedicated microfluidic device that retains mother cells. Developing such tools is crucial to enable high-throughput image analysis. These methods will be useful for researchers studying these cells, and may also inspire similar approaches for other types of cells.

   Reviewed by eLife

9. An extracellular vesicle targeting ligand that binds to Arc proteins and facilitates Arc transport in vivo

   This article has 5 authors:

   1. Peter H Lee
   2. Michael Anaya
   3. Mark S Ladinsky
   4. Justin M Reitsma
   5. Kai Zinn

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     Extracellular vesicles (EVs) are emerging as important mediators of cell-to-cell signaling. Lee et al show convincingly that Stranded at second (Sas), a Drosophila cell surface protein, is trafficked by and localized to Drosophila EVs. However, the data supporting interaction with dArc and whether Sas facilitates the intercellular transfer of dArc protein or mRNA is incomplete. Moreover, almost all experiments rely on gain-of-function and over-expression of Sas, thus the relevance to normal physiological signaling is unclear.

   Reviewed by eLife

10. Single-cell profiling coupled with lineage analysis reveals vagal and sacral neural crest contributions to the developing enteric nervous system

    This article has 4 authors:

    1. Jessica Jacobs-Li
    2. Weiyi Tang
    3. Can Li
    4. Marianne E Bronner

    This article has been curated by 1 group:

    • Curated by eLife

      eLife assessment

      This is an elegant study combining virally-delivered lineage-tracing with single cell RNA-sequencing of the developing chicken enteric nervous system, showing potentially differential contribution of cell identities from the sacral and vagal neural crest. Addressing this important issue is pivotal to understanding basic enteric nervous system development as well as to devise therapeutic approaches to enteric neuropathies. The study is therefore generally interesting and in particular to researchers in the fields of enteric neuroscience and peripheral nervous system development. Lack of a basic classification scheme of neuronal cell types in the chicken, limited computational and functional analysis on a relatively immature stage and makes the conclusions of this work preliminary in its current state.

    Reviewed by eLife