eLife

Latest preprint reviews

1. BlueBerry: Closed-loop wireless optogenetic manipulation in freely moving animals

   This article has 8 authors:

   1. Ali Nourizonoz
   2. Benoit Girard
   3. Maëlle Guyoton
   4. Gregorio Galiñanes
   5. Raphael Thurnherr
   6. Sebastien Pellat
   7. Camilla Bellone
   8. Daniel Huber

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This work presents a valuable new open-source tool for wirelessly controlling optogenetic stimulation in neuroscience experiments in behaving rodents. Evidence for its potential usefulness in different types of optogenetic experiments is solid, although some details and concerns were viewed as lacking or overlooked (e.g., system latency, battery weight). The work is expected to interest neuroscientists working with optogenetics and neuroengineers developing small-sized integrated devices for rodent experiments.

   Reviewed by eLife

2. Spontaneous emergence and evolution of neuronal sequences in recurrent networks

   This article has 3 authors:

   1. Shuai Shao
   2. Juan Luis Riquelme
   3. Julijana Gjorgjieva

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This valuable study presents a plastic recurrent spiking network model that spontaneously generates repeating neuronal sequences under unstructured inputs. The authors provide solid evidence that, while the global weight distribution stabilizes, individual synaptic connections undergo constant turnover with strength-dependent timescales, supporting sequence generation. However, the study is purely simulation-based and phenomenological, lacking both a mechanistic explanation for sequence emergence and explicit experimental predictions, and robustness to alternative, more biologically realistic plasticity rules remains to be demonstrated. The work will be of interest to theoretical and experimental neuroscientists working on synaptic plasticity and neural sequence generation.

   Reviewed by eLife

3. We couldn't get details of this article at this time:
   10.1101/2025.09.15.676366

4. Three-dimensional and molecular brain atlas of the hagfish reveals the evolutionary origin and early diversification of the vertebrate brain

   This article has 5 authors:

   1. Riho Harada
   2. Motoki Tamura
   3. Hirofumi Kariyayama
   4. Shigenori Nonaka
   5. Daichi G Suzuki

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study is useful and unique, since hagfish brains are of phylogenetic importance and can reveal features ancestral to all vertebrates. The manuscript is, however, incomplete and would benefit from contextualization with the current literature; comparisons with the recent amphioxus study are suggested, plus an increased focus on the specific, unique features of the hagfish brain. One significant concern is the apparent absence of Datx2 expression, given that the riboprobe was synthesized from cDNA derived from whole-brain RNA extracts. Ideally, the authors should identify a tissue in which Datx2 is known to be strongly expressed and then apply the probe as a positive control.

   Reviewed by eLife

5. Cross-Species BAC Transgenesis Reveals Long-Range Regulation Drives Variation in Brain Oxytocin Receptor Expression and Social Behaviors

   This article has 12 authors:

   1. Mina Tsukamoto
   2. Luis AE Nagai
   3. Kiyoshi Inoue
   4. Lenin C Kandasamy
   5. Maria F Pires
   6. Minsoo Shin
   7. Yutaro Nagasawa
   8. Tsetsegee Sambuu
   9. Kenta Nakai
   10. Shigeyoshi Itohara
   11. Larry J Young
   12. Qi Zhang

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study provides important insights into how species-specific variation in oxytocin receptor regulatory architecture contributes to diversity in brain expression patterns and social behaviors. By generating multiple BAC transgenic mouse lines carrying the prairie vole oxytocin receptor locus and combining anatomical, molecular, behavioral, and chromatin-structure analyses, the authors present convincing evidence that distal regulatory elements constrain peripheral expression while permitting brain expression aligned with behavior. This study provides an experimental framework and a resource that are of value for dissecting how regulatory variation in neuromodulatory systems contributes to species differences in social behavior. This work will be of interest to those interested in social behavior, oxytocin, neuromodulation, and related conditions.

   Reviewed by eLife

6. Gene synteny and translational coupling of sctS and sctT facilitate assembly of the unique helical T3SS export apparatus in Salmonella Typhimurium

   This article has 7 authors:

   1. Eunjin Kim
   2. Mirjam Forberger
   3. Felix Weichel
   4. Claudia Paroll
   5. Jialin Zhou
   6. Iwan Grin
   7. Samuel Wagner

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     Kim et al. provide important findings explaining how T3SS assembly is regulated by a conserved genetic context. The evidence supporting the conclusions is compelling, with numerous experiments demonstrating the validity of the findings. The work will be of interest to molecular biologists, biochemists, and microbiologists working on secretion systems or similar complexes. Further studies revealing similar mechanisms in other systems would enhance the impact of the current study.

   Reviewed by eLife

7. We couldn't get details of this article at this time:
   10.64898/2026.01.14.699417

8. We couldn't get details of this article at this time:
   10.1101/2025.09.20.677458

9. We couldn't get details of this article at this time:
   10.64898/2026.02.12.705648

10. Hierarchical cross-linking of a bacterial spore coat Hub protein

    This article has 15 authors:

    1. Khira Amara
    2. Catarina Fernandes
    3. David QP Reis
    4. Daniela Silva
    5. Carmen Olivença
    6. Bruno Gonçalves
    7. Tiago Pais
    8. Maria L Martins
    9. Guillem Hernandez
    10. Cristina Timóteo
    11. Ricardo A Gomes
    12. Ana S Pina
    13. Mónica Serrano
    14. Tiago N Cordeiro
    15. Adriano O Henriques

    This article has been curated by 1 group:

    • Curated by eLife

      eLife Assessment

      This valuable article provides a convincing and very detailed model of the process regulating the assembly of the spore coat in the model spore-forming bacterium Bacillus subtilis. It focuses on SafA, a morphogenetic coat protein involved in the assembly of the spore coat inner layer, deciphering the contributions of disulfide bond formation and crosslinking reactions catalyzed by a transglutaminase. The process had been studied with a combination of genetics and microscopy, but this is the first complete assessment incorporating detailed biochemical approaches.

    Reviewed by eLife