Latest preprint reviews

  1. Long-range neural pathways for octopus chemotactile processing revealed from periphery-to-brain by centimeter-field microCT

    This article has 15 authors:
    1. Andrew Sugarman
    2. Daniel Vanselow
    3. David Northover
    4. Stephen L Senft
    5. Carolyn Zaino
    6. Maksim A Yakovlev
    7. Jessica Christ
    8. Justin D Silverman
    9. Mee S Ngu
    10. Khai C Ang
    11. Steve Wang
    12. Wen-Sung Chung
    13. Patrick La Riviere
    14. Roger T Hanlon
    15. Keith C Cheng
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      In this study, the authors use microCT to image an intact hatchling octopus and segment major organ systems, including the vascular, respiratory, digestive, and nervous systems. The resulting dataset is of good quality, and its release through a public web interface is a valuable resource for the community to explore cephalopod mesoscale anatomy. However, the authors claim to have elucidated previously uncharacterized chemotactile pathways from the suckers to the brain, for which there is incomplete evidence, as microCT does not reveal structural connectivity. In addition, the language is often overly complex, obscuring the main points and making it difficult to assess the strength of individual claims. This article would benefit from more cautious framing of the anatomical findings and complementary neuronal tracing experiments to support the proposed pathways.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  2. Gene specificity landscapes for comparative transcriptomic analysis across tissues, cell types, and species

    This article has 2 authors:
    1. Erik Bot
    2. Jose Davila-Velderrain
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This important study advances a new computational approach to measure and visualize gene expression specificity across different tissues and cell types. The framework is potentially helpful for improving the way gene expression specificity is defined across biological datasets, especially among single-cell datasets. The evidence supporting the method is generally solid, although further evaluation of the method's robustness and comparison to other approaches would strengthen the conclusions.

    Reviewed by eLife

    This article has 3 evaluationsAppears in 1 listLatest version Latest activity
  3. Dopaminergic Modulation of Mushroom Body Output Neurons Mediates Nociception-Induced Escape in Drosophila

    This article has 9 authors:
    1. Chi-Lien Yang
    2. Chia-Wen Chen
    3. Kuan-Lin Feng
    4. Hsiao-Chien Peng
    5. Ming-Chin Wu
    6. Ching-Che Charng
    7. Li-An Chu
    8. Yeong-Ray Wen
    9. Ann-Shyn Chiang
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This study presents important findings for the understanding of central brain circuits that underlie nociception-induced escape. Using a laser-based nociception assay, chronic neuronal silencing, trans-Tango anatomical tracing, and reference to connectomic data, the authors propose that nociceptive signals (from painless- and trpA1-expressing neurons) converge on a subset of dopaminergic neurons (subsets of PPL1 and PAM), which in turn engage mushroom body output neurons (MBONs) to shape escape latency. However, methods and controls fall short of fully supporting the findings, rendering the evidence incomplete. This study will be of interest to scientists studying nociception and learning and memory circuits.

    Reviewed by eLife

    This article has 5 evaluationsAppears in 1 listLatest version Latest activity
  4. Negative-Valence Neurons in the Larval Zebrafish Pallium

    This article has 6 authors:
    1. Colton D Smith
    2. Zhuowei Du
    3. William P Dempsey
    4. Scott E Fraser
    5. Thai V Truong
    6. Don B Arnold
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This valuable work identifies a subpopulation of neurons in the larval zebrafish pallium that responds differentially to varying threat levels, potentially mediating the categorization of negative valence. The evidence supporting these claims is solid; however, the study would be strengthened by more sophisticated analyses of functional imaging results, behavioral confirmation of stimulus valence, and further evidence linking the functionally distinct clusters to their molecular identity. This work will be of interest to systems neuroscientists investigating the circuit-level encoding of emotion and defensive behavior.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  5. Speech is defined by theta-gamma coupled acoustic rhythms, mapped onto segregated populations in human early auditory cortex

    This article has 10 authors:
    1. Víctor J López-Madrona
    2. Jérémy Giroud
    3. Manuel Mercier
    4. Léonardo Lancia
    5. Bruno L Giordano
    6. Agnès Trébuchon
    7. David Poeppel
    8. Anne-Lise Giraud
    9. Luc H Arnal
    10. Benjamin Morillon
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This manuscript presents important findings that challenge traditional models of speech processing by demonstrating that theta-gamma phase-amplitude coupling in the auditory cortex is primarily a stimulus-driven alignment to external acoustic structures rather than an intrinsic neural oscillatory mechanism. The evidence supporting these claims is convincing, grounded in a robust cross-linguistic acoustic analysis and high-fidelity, time-resolved intracranial recordings.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  6. Infant Brains Tick at 4Hz – Resonance Properties of the Developing Visual System

    This article has 3 authors:
    1. Marlena Baldauf
    2. Ole Jensen
    3. Moritz Köster
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This is a potentially important study comparing infants (8 months) and adults with respect to rhythmic EEG response properties during periodic and aperiodic visual stimulation. The results provide solid evidence for a ~4 Hz EEG response in infants that emerges independently of stimulation frequency. At this stage, additional work will be required to conclusively establish that this theta-band effect reflects genuine neural resonance rather than oculomotor processes.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
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