Latest preprint reviews

  1. Avoiding false discoveries in single-cell RNA-seq by revisiting the first Alzheimer’s disease dataset

    This article has 3 authors:
    1. Alan E Murphy
    2. Nurun Fancy
    3. Nathan Skene
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This paper reports a useful finding on the impact of choices of quality control and differential analysis methods on the discovery of disease-associated gene expression signatures. The study provides a solid comparison of the data process by re-analysis of a large-scale snRNA-seq dataset for Alzheimer's Disease. This paper would be of interest to the community as to rigorous analyses for large-scale single cell datasets.

    Reviewed by eLife

    This article has 6 evaluationsAppears in 1 listLatest version Latest activity
  2. Dynamic landscape of the intracellular termini of acid-sensing ion channel 1a

    This article has 4 authors:
    1. Megan M Cullinan
    2. Robert C Klipp
    3. Abigail Camenisch
    4. John R Bankston
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This valuable study illuminates molecular movements of acid-sensing ion channels by combining advanced chemical biology and biophysical techniques. The evidence for the main claim, lack of interaction of molecular termini, is compelling and challenges prior models. This work is expected to pique interest in the ion channel signaling field, providing a fresh perspective.

    Reviewed by eLife

    This article has 9 evaluationsAppears in 1 listLatest version Latest activity
  3. Postsynaptic mitochondria are positioned to support functional diversity of dendritic spines

    This article has 4 authors:
    1. Connon I Thomas
    2. Melissa A Ryan
    3. Naomi Kamasawa
    4. Benjamin Scholl
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This study reports valuable findings on the correlation between the positions of dendritic mitochondria and the orientation preference of calcium responses of individual spines. The conclusion about the biased localization of dendritic mitochondria near functional diverse spines is informative to understand the functions of dendritic mitochondria. The experimental evidence supporting the conclusion is compelling.

    Reviewed by eLife

    This article has 9 evaluationsAppears in 1 listLatest version Latest activity
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