Latest preprint reviews

  1. Zona incerta distributes a broad movement signal that modulates behavior

    This article has 6 authors:
    1. Sebastian Hormigo
    2. Ji Zhou
    3. Dorian Chabbert
    4. Sarmad Sajid
    5. Natan Busel
    6. Manuel Castro-Alamancos
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This important study uses a range of technical approaches to investigate the responses of zona incerta neurons to movement and sensory stimuli. The majority of neurons exhibited movement related activity but only a small proportion were modulated by whisker deflections. The major conclusion of the study is that the zona incerta distributes a general motor signal. The evidence supporting this claim is solid, although the study would be improved by greater transparency and discussion of experimental methods and histological verification of recording sites, viral spread, and which territories of the zona incerta were investigated. The work will be of interest to behavioral and physiological neuroscientists.

    Reviewed by eLife

    This article has 6 evaluationsAppears in 1 listLatest version Latest activity
  2. Structural basis for kinase inhibition in the tripartite E. coli HipBST toxin–antitoxin system

    This article has 9 authors:
    1. René L Bærentsen
    2. Stine V Nielsen
    3. Ragnhild B Skjerning
    4. Jeppe Lyngsø
    5. Francesco Bisiak
    6. Jan Skov Pedersen
    7. Kenn Gerdes
    8. Michael A Sørensen
    9. Ditlev E Brodersen
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This important study presents an exhaustive structural analysis of a complete tripartite HipBST toxin-antitoxin system of the Enteropathogenic E. coli O127:H6, which represents a fascinating variation on the well-studied HipAB toxin-antitoxin system. The convincing data show that major features of the canonical HipAB system have been rerouted to form the tripartite HipBST, revealing a new mode of inhibition of a toxin kinase.

    Reviewed by eLife

    This article has 8 evaluationsAppears in 1 listLatest version Latest activity
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