eLife

Latest preprint reviews

1. The mitochondrial stress-induced protein carboxyl-terminal alanine and threonine tailing (msiCAT-tailing) promotes glioblastoma tumorigenesis by modulating mitochondrial functions

   This article has 10 authors:

   1. Ting Cai
   2. Bei Zhang
   3. Esha Reddy
   4. Yuanna Wu
   5. Yinglu Tang
   6. Isha Mondal
   7. Jerry Wang
   8. Winson S Ho
   9. Rongze Olivia Lu
   10. Zhihao Wu

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     Glioblastoma is one of the most aggressive cancers without a cure. Glioblastoma cells are known to have high mitochondrial potential. This useful study demonstrates the critical role of the ribosome-associated quality control (RQC) pathway in regulating mitochondrial membrane potential and glioblastoma growth. Some assays are incomplete; further revision will improve the significance of this study.

   Reviewed by eLife

2. Multiomics reveals gut dysbiosis links to fatty acid dysmetabolism in early phase of acute myocardial infarction

   This article has 31 authors:

   1. Jiajun Ying
   2. Yong Fan
   3. Ning Huangfu
   4. Kewan He
   5. Teng Hu
   6. Pengpeng Su
   7. Xintao Hu
   8. Hequn He
   9. Wei Liang
   10. Junsong Liu
   11. Jinsong Cheng
   12. Shiqi Wang
   13. Ruochi Zhao
   14. Hengyi Mao
   15. Fuwei He
   16. Jia Su
   17. Honglin Zhou
   18. Zhenwei Li
   19. Xiaohong Fei
   20. Xiafei Sun
   21. Peipei Wang
   22. Minfang Guan
   23. Weiping Du
   24. Shaoyi Lin
   25. Yong Wang
   26. Fangkun Yang
   27. Renyuan Fang
   28. Ziqing Kong
   29. Xiaomin Chen
   30. Hanbin Cui
   31. Jiajun Ying and Yong Fan contributed equally to this work

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study provides valuable information about the microbiome and metabolome, and their correlation with acute myocardial infarction. However, the relationship established between these variables is limited to a correlation, and therefore the strength of the evidence is incomplete.

   Reviewed by eLife

3. Artesunate, EDTA and colistin work synergistically against MCR-negative and -positive colistin-resistant Salmonella

   This article has 10 authors:

   1. Yajun Zhai
   2. Peiyi Liu
   3. Xueqin Hu
   4. Changjian Fan
   5. Xiaodie Cui
   6. Qibiao He
   7. Dandan He
   8. Xiaoyuan Ma
   9. Gongzheng Hu
   10. Yajun Zhai

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study provides valuable insights, addressing the growing threat of multi-drug-resistant (MDR) pathogens by focusing on the enhanced efficacy of colistin when combined with artesunate and EDTA against colistin-resistant Salmonella strains. The evidence is solid, supported by comprehensive microbiological assays, molecular analyses, and in vivo experiments demonstrating the effectiveness of this synergic combination. However, the discussion on the clinical application challenges of this triple combination is incomplete, and it would benefit from addressing the high risk associated with using three potential nephrotoxic agents in vivo.

   Reviewed by eLife

4. Heterogeneous efflux pump expression underpins phenotypic resistance to antimicrobial peptides

   This article has 18 authors:

   1. Ka Kiu Lee
   2. Urszula Łapińska
   3. Giulia Tolle
   4. Wanida Phetsang
   5. Anthony D Verderosa
   6. Brandon M Invergo
   7. Joseph Westley
   8. Attila Bebes
   9. Raif Yuecel
   10. Paul A O’Neill
   11. Audrey Farbos
   12. Aaron R Jeffries
   13. Stineke van Houte
   14. Pierluigi Caboni
   15. Mark AT Blaskovich
   16. Benjamin E Housden
   17. Krasimira Tsaneva-Atanasova
   18. Stefano Pagliara

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important study by Lee et al. investigates the heterogeneous response of non-growing bacteria to the antimicrobial peptide (AMP) tachyplesin. In this response, a subpopulation of bacteria limits the accumulation of a fluorescent analog of the AMP, avoiding lethal damage. The study provides compelling data showing the differential accumulation of AMP in subpopulations and its correlation with antimicrobial efficacy. However, the evidence for increased efflux as the main survival mechanism remains incomplete.

   Reviewed by eLife

5. Apoptotic caspases cleave DRP1 to promote mitochondrial fusion and anti-viral immune responses

   This article has 6 authors:

   1. Yujie Fang
   2. Zihan Guan
   3. Xiangtao Zhu
   4. Zhenqiong Guan
   5. Shufen Li
   6. Ke Peng

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This manuscript describes an unexpected role of cellular caspases in cleaving Drp1, a protein involved in mitochondrial fission, in virus-infected cells. Drp1 cleavage augments mitochondrial fission, reinforcing MAVS-dependent type-1 IFN response against multiple viruses. The findings presented in this manuscript are important and the strength of evidence is solid. Additional studies may allow for more robust mechanistic substantiation of the proposed model.

   Reviewed by eLife

6. Transplantation of exogenous mitochondria mitigates myocardial dysfunction after cardiac arrest

   This article has 8 authors:

   1. Zhen Wang
   2. Jie Zhu
   3. Mengda Xu
   4. Xuyuan Ma
   5. Maozheng Shen
   6. Jingyu Yan
   7. Guosheng Gan
   8. Xiang Zhou

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study presents valuable findings on how mitochondrial transplantation affects post-cardiac arrest myocardial dysfunction (PAMD). The authors demonstrate that mitochondrial transplantation enhances cardiac function, increases survival rates after the return of spontaneous circulation (ROSC). While the findings are promising, the organization of the paper, along with the analysis and interpretation of the results, are inadequate and need revision.

   Reviewed by eLife

7. Acute targeted induction of gut-microbial metabolism affects host clock genes and nocturnal feeding

   This article has 9 authors:

   1. Giorgia Greter
   2. Claudia Moresi
   3. Stefanie Oswald
   4. Alice de Wouters d’Oplinter
   5. Daria Künzli
   6. Elisa Cappio Barazzone
   7. Jiayi Lan
   8. Emma Slack
   9. Markus Arnoldini

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     Feeding, the circadian rhythm, and the gut microbiota are all intimately linked, motivating new approaches to identify causal relationships while minimizing confounding factors. The authors employ an innovative combination of the stool softener lactulose and a defined 3-member gut microbiota to acutely induce gut bacterial metabolism in mice during the daytime, resulting in changes in the ileal expression of clock genes and altered feeding behavior. Together, this study utilizes solid methods to provide important new insights into the role of gut microbiota in the circadian rhythm, setting the stage for follow-on studies aimed at better understanding the mechanisms responsible.

   Reviewed by eLife

8. Structural epitope profiling identifies antibodies associated with critical COVID-19 and long COVID

   This article has 37 authors:

   1. Patrick KA Kearns
   2. Charles Dixon
   3. Mihaly Badonyi
   4. Kim Lee
   5. Rafal Czapiewski
   6. Olivia Fleming
   7. Prajitha Nadukkandy
   8. Lukas Gerasimivicius
   9. Rinal Sahputra
   10. Bethany Potts
   11. Sam Benton
   12. Jacky Guy
   13. Scott Neilson
   14. Helen Wise
   15. Sara Jenks
   16. Kate Templeton
   17. CIRCO
   18. Christina Dold
   19. Teresa Lambe
   20. Andrew Pollard
   21. Alexander J Mentzer
   22. Julian C Knight
   23. COMBAT
   24. Susanna Dunachie
   25. Paul Klenerman
   26. Eleanor Barnes
   27. Alan Carson
   28. Laura McWhirter
   29. Tracy Hussell
   30. Rennos Fragkoudis
   31. Susan Rosser
   32. David Cavanagh
   33. Graeme Cowan
   34. Madhvi Menon
   35. Joseph A Marsh
   36. Dirk A Kleinjan
   37. Nick Gilbert

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study provides novel insights into COVID-19 immune responses by using the delta of the normalised accessible surface area (DASA) to map IgM responses to the SARS-CoV-2 Membrane protein M1-subtype across multiple European cohorts. The evidence supporting the findings is solid, with thorough validation and comprehensive analysis, although additional clarity on T-independent B cell reactions and the impact of comorbidities would further strengthen the conclusions. The methods and data presented are valuable for advancing diagnostic and prognostic tools for COVID-19, particularly in the context of long COVID.

   Reviewed by eLife

9. The title and authors for this article are not available from our external data provider yet:
   10.48550/arxiv.2401.04873v2

10. Noncanonical roles of ATG5 and membrane atg8ylation in retromer assembly and function

    This article has 12 authors:

    1. Masroor Ahmad Paddar
    2. Fulong Wang
    3. Einar S Trosdal
    4. Emily Hendrix
    5. Yi He
    6. Michelle Salemi
    7. Michal Mudd
    8. Jingyue Jia
    9. Thabata L A Duque
    10. Ruheena Javed
    11. Brett Phinney
    12. Vojo Deretic

    This article has been curated by 1 group:

    • Curated by eLife

      eLife assessment

      This important work identifies a non-autophagic role for ATG5 in lysosomal repair and the trafficking of the glucose transporter GLUT1 to the cell surface, mediated through the retromer complex. The evidence supporting the conclusions is solid.

    Reviewed by eLife