Latest preprint reviews

  1. A reservoir of timescales emerges in recurrent circuits with heterogeneous neural assemblies

    This article has 3 authors:
    1. Merav Stern
    2. Nicolae Istrate
    3. Luca Mazzucato
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This fundamental work uses computational network models to suggest a possible origin of the wide range of time scales observed in cortical activity. This claim is supported by convincing evidence based on comparisons between mathematical theory, simulations of spiking network models, and analysis of recordings from the orbitofrontal cortex. This manuscript will be of interest to the broad community of systems and computational neuroscience.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  2. Modulation of protein-DNA binding reveals mechanisms of spatiotemporal gene control in early Drosophila embryos

    This article has 3 authors:
    1. Sahla Syed
    2. Yifei Duan
    3. Bomyi Lim
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This valuable work explores how transcription factors regulate transcription through cooperative binding to enhancers. Through experiments and modeling, the authors show convincingly that the cooperativity of transcription factor binding regulates transcriptional bursting and the extent of the amount of time that the target promoter remains in an active state.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  3. Interpersonal alignment of neural evidence accumulation to social exchange of confidence

    This article has 4 authors:
    1. Jamal Esmaily
    2. Sajjad Zabbah
    3. Reza Ebrahimpour
    4. Bahador Bahrami
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      In this important study, Esmaily and colleagues investigate the "confidence matching" between two agents and present a useful exploration of its computational and physiological correlates. Further analyses would be helpful to provide a tighter link between fluctuations of confidence, pupil size, EEG response, and computational variables, to delineate the causal relations between these quantities, which are nevertheless incompletely documented at present.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  4. Nicotinic acetylcholine receptor signaling maintains epithelial barrier integrity

    This article has 12 authors:
    1. Nadja S Katheder
    2. Kristen C Browder
    3. Diana Chang
    4. Ann De Maziere
    5. Pekka Kujala
    6. Suzanne van Dijk
    7. Judith Klumperman
    8. Tzu-Chiao Lu
    9. Hongjie Li
    10. Zijuan Lai
    11. Dewakar Sangaraju
    12. Heinrich Jasper
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This study reveals a novel mechanism of Acetylcholine- Acetylylcholine receptor signaling in regulating gut barrier function in Drosophila, which provides important implications on the pathway played in human diseases, such as Chronic Obstructive Pulmonary DiseaseCOPD. The evidence supporting the claims of the authors is solid.

    Reviewed by eLife

    This article has 3 evaluationsAppears in 1 listLatest version Latest activity
  5. Long-timescale anti-directional rotation in Drosophila optomotor behavior

    This article has 9 authors:
    1. Omer Mano
    2. Minseung Choi
    3. Ryosuke Tanaka
    4. Matthew S Creamer
    5. Natalia CB Matos
    6. Joseph W Shomar
    7. Bara A Badwan
    8. Thomas R Clandinin
    9. Damon A Clark
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      The present study provides a valuable new perspective on the optomotor response based on an inversion of the behavior under specific (non-natural) conditions that may help elucidate the principles of this specific behavior. The evidence provided is convincing.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  6. Erythrocyte invasion-neutralising antibodies prevent Plasmodium falciparum RH5 from binding to basigin-containing membrane protein complexes

    This article has 9 authors:
    1. Abhishek Jamwal
    2. Cristina F Constantin
    3. Stephan Hirschi
    4. Sebastian Henrich
    5. Wolfgang Bildl
    6. Bernd Fakler
    7. Simon J Draper
    8. Uwe Schulte
    9. Matthew K Higgins
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This elegantly performed and rigorous study generates new and conceptually important insights into the interaction between an essential malaria parasite invasion ligand (and vaccine candidate) called PfRH5, and its erythrocyte surface integral membrane receptor basigin. The authors provide compelling evidence based on rigorous biochemical assays that erythrocyte basigin is predominantly expressed in a complex with one of two distinct erythrocyte membrane proteins called PMCA and MCT1 and that PfRH5 binds to these complexes better than to isolated basigin. Certain invasion-inhibitory antibodies, that do not prevent binding of PfRH5 to isolated basigin, do in contrast prevent binding to the basigin complexes, explaining the mode of action of these previously enigmatic antibodies and providing valuable data towards the improved design of vaccines based on PfRH5.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  7. A comprehensive model of Drosophila epithelium reveals the role of embryo geometry and cell topology in mechanical responses

    This article has 8 authors:
    1. Mohamad Ibrahim Cheikh
    2. Joel Tchoufag
    3. Miriam Osterfield
    4. Kevin Dean
    5. Swayamdipta Bhaduri
    6. Chuzhong Zhang
    7. Kranthi Kiran Mandadapu
    8. Konstantin Doubrovinski
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      Using a novel micropipette-based, minimally invasive approach in combination with theoretical and computational analysis, this important work probes tissue mechanics in the Drosophila embryo. The authors provide compelling evidence for the applicability of their method, which reveals important differences between the mechanical properties on the apical and basal tissue sides. This work should be of broad interest to scientists studying tissue mechanics, membranes, and developmental processes.

    Reviewed by eLife

    This article has 3 evaluationsAppears in 1 listLatest version Latest activity
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