eLife

Latest preprint reviews

1. Coupling of Slack and NaV1.6 sensitizes Slack to quinidine blockade and guides anti-seizure strategy development

   This article has 18 authors:

   1. Tian Yuan
   2. Yifan Wang
   3. Yuchen Jin
   4. Hui Yang
   5. Shuai Xu
   6. Heng Zhang
   7. Qian Chen
   8. Na Li
   9. Xinyue Ma
   10. Huifang Song
   11. Chao Peng
   12. Ze Geng
   13. Jie Dong
   14. Guifang Duan
   15. Qi Sun
   16. Yang Yang
   17. Fan Yang
   18. Zhuo Huang

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     The authors report that an interaction between the sodium-activated potassium channel Slack and Nav1.6 sensitizes Slack to inhibition by quinidine. This is an important finding because it contributes to our understanding of how the antiseizure drug quinidine affects epilepsy syndromes arising from mutations in the Slack-encoding gene KCNT1. The results are largely compelling and the work will likely spark interest in further examining the proposed channel-channel interaction in neuronal cell membranes.

   Reviewed by eLife

2. A generative model of electrophysiological brain responses to stimulation

   This article has 1 author:

   1. Diego Vidaurre

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study presents a valuable finding on developing a state-of-the-art generative model of brain electrophysiological signals to explain temporal decoding matrices widely used in cognitive neuroscience. The evidence supporting the authors' claims is convincing. The results will be strengthened by providing more clear mappings between neurobiological mechanisms and signal generators in the model. The work will be of interest to cognitive neuroscientists using electrophysiological recordings.

   Reviewed by eLife

3. Mesotrode allows chronic simultaneous mesoscale cortical imaging and subcortical or peripheral nerve spiking activity recording in mice

   This article has 3 authors:

   1. Dongsheng Xiao
   2. Yuhao Yan
   3. Timothy H Murphy

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This valuable study combines chronic widefield calcium imaging of dorsal cortex activity at the mesoscale level with electrical recording of single neurons in specific cortical and subcortical locations. This work provides compelling evidence for recording neuronal activity at multiple temporal and spatial scales by combination of optical and electrophysiological methods. This work will be of broad interest to system neuroscientists studying neural circuits.

   Reviewed by eLife

4. The scheduling of adolescence with Netrin-1 and UNC5C

   This article has 17 authors:

   1. Daniel Hoops
   2. Robert Kyne
   3. Samer Salameh
   4. Del MacGowan
   5. Radu Gabriel Avramescu
   6. Elise Ewing
   7. Alina Tao He
   8. Taylor Orsini
   9. Anais Durand
   10. Christina Popescu
   11. Janet Mengyi Zhao
   12. Kelcie Shatz
   13. LiPing Li
   14. Quinn Carroll
   15. Guofa Liu
   16. Matthew J Paul
   17. Cecilia Flores

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study addresses an important, understudied question using approaches that link molecular, circuit, and behavioral changes. The findings that Netrin-1 and UNC5c can guide dopaminergic innervation from the nucleus accumbens to the cortex during adolescence are solid. The data showing that the onset of Unc5 expression is sexually dimorphic in mice, and that in Siberian hamsters environmental effects on development are also sexually dimorphic are also solid. Reviewers identified significant gaps in evidence for specificity of Netrin-1 expression, which, if filled, would strengthen the evidence for some of the claims. Future work would also benefit from Unc5C knockdown to corroborate the results and investigation of the cause-effect relationship. This paper will be of interest to those interested in neural development, sex differences, and/or dopamine function.

   Reviewed by eLife

5. Approach-avoidance reinforcement learning as a translational and computational model of anxiety-related avoidance

   This article has 3 authors:

   1. Yumeya Yamamori
   2. Oliver J Robinson
   3. Jonathan P Roiser

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This is a valuable paper demonstrating the validity of a novel task that could advance the field of reinforcement learning to better incorporate threat processing in approach-avoidance-conflict. A compelling methodology includes the use of online samples and computational modelling, psychometrics, discovery/replication and pre-registration. This work provides a foundation for future work, which is required to establish this task as relevant to psychopathology and treatment.

   Reviewed by eLife

6. Somatotopic organization among parallel sensory pathways that promote a grooming sequence in Drosophila

   This article has 9 authors:

   1. Katharina Eichler
   2. Stefanie Hampel
   3. Adrián Alejandro-García
   4. Steven A Calle-Schuler
   5. Alexis Santana-Cruz
   6. Lucia Kmecova
   7. Jonathan M Blagburn
   8. Eric D Hoopfer
   9. Andrew M Seeds

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This valuable work provides a near-complete description of the mechanosensory bristles on the Drosophila melanogaster head and the anatomy and projection patterns of the bristle mechanosensory neurons that innervate them. The data presented are solid. The study has generated numerous resources for the community that will be of interest to neuroscientists in the field of circuits and behaviour, particularly those interested in mechanosensation and behavioural sequence generation.

   Reviewed by eLife

7. Mechanism of stepwise electron transfer in six-transmembrane epithelial antigen of the prostate (STEAP) 1 and 2

   This article has 6 authors:

   1. Kehan Chen
   2. Lie Wang
   3. Jiemin Shen
   4. Ah-Lim Tsai
   5. Ming Zhou
   6. Gang Wu

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study provides useful insights into the mechanisms of electron transport in STEAP proteins, consistent with current models. The work strengthens and supports previously published biochemical and structural data, and the experimental results are of solid technical quality. The manuscript will be of interest to colleagues who work on STEAP proteins and related electron transfer systems.

   Reviewed by eLife

8. Glutaredoxin regulation of primary root growth is associated with early drought stress tolerance in pearl millet

   This article has 34 authors:

   1. Carla de la Fuente
   2. Alexandre Grondin
   3. Bassirou Sine
   4. Marilyne Debieu
   5. Christophe Belin
   6. Amir Hajjarpoor
   7. Jonathan A Atkinson
   8. Sixtine Passot
   9. Marine Salson
   10. Julie Orjuela
   11. Christine Tranchant-Dubreuil
   12. Jean-Rémy Brossier
   13. Maxime Steffen
   14. Charlotte Morgado
   15. Hang Ngan Dinh
   16. Bipin K Pandey
   17. Julie Darmau
   18. Antony Champion
   19. Anne-Sophie Petitot
   20. Celia Barrachina
   21. Marine Pratlong
   22. Thibault Mounier
   23. Princia Nakombo-Gbassault
   24. Pascal Gantet
   25. Prakash Gangashetty
   26. Yann Guedon
   27. Vincent Vadez
   28. Jean-Philippe Reichheld
   29. Malcolm J Bennett
   30. Ndjido Ardo Kane
   31. Soazig Guyomarc'h
   32. Darren M Wells
   33. Yves Vigouroux
   34. Laurent Laplaze

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This is an important paper that combines methods ranging from agronomy and plant breeding to Arabidopsis functional genetics, to argue that polymorphism in a single gene affects crop yield in pearl millet by affecting root cell elongation and drought stress resilience in a poorly studied crop. The overall argument is plausible but whether the solid evidence generated with Arabidopsis experiments can be extended to pearl millet itself is unclear.

   Reviewed by eLife

9. Bactabolize is a tool for high-throughput generation of bacterial strain-specific metabolic models

   This article has 9 authors:

   1. Ben Vezina
   2. Stephen C Watts
   3. Jane Hawkey
   4. Helena B Cooper
   5. Louise M Judd
   6. Adam WJ Jenney
   7. Jonathan M Monk
   8. Kathryn E Holt
   9. Kelly L Wyres

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study presents Bactabolize, a valuable tool for the rapid genome-scale reconstruction of bacteria and the prediction of growth phenotypes. Using validated methodology, the tool relies on a reference pan-genome model to create strain-specific draft metabolic models, as demonstrated in this study using Klebsiella pneumoniae. While the evidence in this specific case is solid, validation across diverse bacterial species is yet to be confirmed.

   Reviewed by eLife

10. Light-inducible protein degradation in E. coli with the LOVdeg tag

    This article has 4 authors:

    1. Nathan Tague
    2. Cristian Coriano-Ortiz
    3. Michael B Sheets
    4. Mary J Dunlop

    This article has been curated by 1 group:

    • Curated by eLife

      eLife assessment

      This valuable study reports on a new tool that allows for light-controlled protein degradation in Escherichia coli. With the improved light-responsive protein tag, endogenous protein levels can be reduced severalfold. The methodology is convincing and will be of interest to the fields of gene expression regulation in bacteria and, more generally to synthetic biologists.

    Reviewed by eLife