eLife

Latest preprint reviews

1. Adult-born granule cells improve stimulus encoding and discrimination in the dentate gyrus

   This article has 3 authors:

   1. Diego M Arribas
   2. Antonia Marin-Burgin
   3. Luis G Morelli

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This paper is of potential interest to both the hippocampal and computational neuroscience fields because it provides a framework for understanding how adult-born granule cells in the hippocampus contribute to network processing. It contains novel interesting ideas, such as the analysis of input-output transformation by SRM models and the establishment of "greedy networks". However, not all major conclusions are sufficiently supported by the data. The paper demonstrates that mixed networks show better encoding performance than pure networks, but the differences are small and only visible with specific performance metrics. Intuitive explanations are not provided.

   Reviewed by eLife

2. The yeast endocytic early/sorting compartment exists as an independent sub-compartment within the trans-Golgi network

   This article has 7 authors:

   1. Junko Y Toshima
   2. Ayana Tsukahara
   3. Makoto Nagano
   4. Takuro Tojima
   5. Daria E Siekhaus
   6. Akihiko Nakano
   7. Jiro Toshima

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     In this study, the authors use high-speed and high-resolution imaging to investigate the role of the yeast syntaxin homolog Tlg2p in endocytic vesicle sorting. They obtain compelling data to show that the Tlg2p-residing compartment within the trans-Golgi network functions as an early/sorting compartment, where endocytic cargos are sorted to either the recycling pathway or the endo-lysosomal pathway. The authors also describe additional molecular details of this sorting process, and overall provide important insights into the mechanism of endocytic vesicle sorting in budding yeast.

   Reviewed by eLife

3. Genome editing of an African elite rice variety confers resistance against endemic and emerging Xanthomonas oryzae pv. oryzae strains

   This article has 21 authors:

   1. Van Schepler-Luu
   2. Coline Sciallano
   3. Melissa Stiebner
   4. Chonghui Ji
   5. Gabriel Boulard
   6. Amadou Diallo
   7. Florence Auguy
   8. Si Nian Char
   9. Yugander Arra
   10. Kyrylo Schenstnyi
   11. Marcel Buchholzer
   12. Eliza PI Loo
   13. Atugonza L Bilaro
   14. David Lihepanyama
   15. Mohammed Mkuya
   16. Rosemary Murori
   17. Ricardo Oliva
   18. Sebastien Cunnac
   19. Bing Yang
   20. Boris Szurek
   21. Wolf B Frommer

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This valuable study shows that new, virulent genotypes of Xanthomonas oryze pv. oryzae, that are similar to strains present in east Asia, cause outbreaks of bacterial blight of rice in Tanzania. The authors' use of CRISPR-based gene editing on multiple pathogen targets in an elite African rice variety to create lines resistant to both endemic and emerging pathogen strains in Africa makes for a compelling contribution to meet this alarming development. The work describing the new strains of the pathogen is solid but could be stronger if there were genome sequence data for all strains examined and a clearer presentation of recent disease outbreaks and their severity.

   Reviewed by eLife

4. Role of the postinspiratory complex in regulating swallow–breathing coordination and other laryngeal behaviors

   This article has 4 authors:

   1. Alyssa Huff
   2. Marlusa Karlen-Amarante
   3. Luiz M Oliveira
   4. Jan-Marino Ramirez

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     The findings in this study are important, as this brainstem region is implicated in a multitude of functions. The experimental procedures are difficult to implement and the preparation used and the skill required are impressive. The methods and data are solid, however, some analyses are incomplete, and the strength of evidence is also incomplete because the claims are only partially supported by the data. This work will interest those who study respiration, airway protection, and other oral behaviors.

   Reviewed by eLife

5. Phosphorylation of tyrosine 90 in SH3 domain is a new regulatory switch controlling Src kinase

   This article has 10 authors:

   1. Lenka Koudelková
   2. Markéta Pelantová
   3. Zuzana Brůhová
   4. Martin Sztacho
   5. Vojtěch Pavlík
   6. Dalibor Pánek
   7. Jakub Gemperle
   8. Pavel Talacko
   9. Jan Brábek
   10. Daniel Rösel

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This manuscript explores the potential regulatory role of a previously unstudied phosphorylation site in the Src kinase SH3 domain. A mutant intended to mimic the phosphorylation of this site, Y90E, shows enhanced activity and transforming capacity, reduced mobility in the lipid bilayer, and a more open catalytic structure. In general, these findings are supported by compelling evidence. The paper will be of interest to biochemists and structural biologists studying new mechanisms that are capable of modulating the allosteric regulation of multi-domain protein kinases.

   Reviewed by eLife

6. Neuromodulation of striatal D1 cells shapes BOLD fluctuations in anatomically connected thalamic and cortical regions

   This article has 7 authors:

   1. Marija Markicevic
   2. Oliver Sturman
   3. Johannes Bohacek
   4. Markus Rudin
   5. Valerio Zerbi
   6. Ben D Fulcher
   7. Nicole Wenderoth

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     Using chemogenetic manipulation, the authors induce or suppress activity in D1 spiny neurons in the dorsomedial striatum of mice. The results effectively demonstrate that excitation or inhibition of this class of neurons results in a consistent behavioral effect that is linked to an impact on local dynamics in thalamic regions that project to this part of the thalamus, as well as cortical regions that can be more readily defined as unimodal as identified by a classification approach. This work has clear relevance to the field of neuroimaging, getting at the broader hemodynamic signatures of direct pathway stimulation in the striatum, but requires critical revisions to justify their main conclusions.

     Using chemogenetic manipulation, the authors induce or suppress activity in D1 spiny neurons in the dorsomedial striatum of mice. The results effectively demonstrate that excitation or inhibition of this class of neurons results in a consistent behavioral effect that is linked to an impact on local dynamics in thalamic regions that project to this part of the thalamus, as well as cortical regions that can be more readily defined as unimodal as identified by a classification approach. This work has clear relevance to the field of neuroimaging, getting at the broader hemodynamic signatures of direct pathway stimulation in the striatum, but requires critical revisions to justify their main conclusions.

   Reviewed by eLife

7. The Uso1 globular head interacts with SNAREs to maintain viability even in the absence of the coiled-coil domain

   This article has 8 authors:

   1. Ignacio Bravo-Plaza
   2. Victor G Tagua
   3. Herbert N Arst
   4. Ana Alonso
   5. Mario Pinar
   6. Begoña Monterroso
   7. Antonio Galindo
   8. Miguel A Peñalva

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This paper reports a detailed functional analysis of the Rab1 effector Uso1, and it provides a fundamental advance in our understanding of how ER-derived vesicles deliver their cargo. The authors provide compelling evidence that the key function of Uso1 is promoting SNARE complex formation rather than tethering vesicles as generally assumed. These insights will be of interest to cell and structural biologists who study membrane traffic.

   Reviewed by eLife

8. Il-6 signaling exacerbates hallmarks of chronic tendon disease by stimulating reparative fibroblasts

   This article has 6 authors:

   1. Tino Stauber
   2. Greta Moschini
   3. Amro A Hussien
   4. Patrick Klaus Jaeger
   5. Katrien De Bock
   6. Jess G Snedeker

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important study defines signaling mechanisms in tendinopathy development, which is significant as there is a clear need to identify therapeutic targets to prevent or reverse tendon pathology. The evidence supporting the conclusions are compelling combining an existing human tendinopathy transcriptomics dataset with ex-vivo assembloid model, and an in vivo injury model using genetic reporter mice. This work will be of interest to developmental and stem cell biologists.

   Reviewed by eLife

9. Chemo- and optogenetic activation of hypothalamic Foxb1-expressing neurons and their terminal endings in the rostral-dorsolateral PAG leads to tachypnea, bradycardia, and immobility

   This article has 7 authors:

   1. Reto B Cola
   2. Diana M Roccaro-Waldmeyer
   3. Samara Naim
   4. Alexandre Babalian
   5. Petra Seebeck
   6. Gonzalo Alvarez-Bolado
   7. Marco R Celio

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This paper describes valuable results from studies investigating circuits in the brain that underlie behavioral responses in fearful situations. The authors identified a role for a class of neurons that are sufficient to cause these stereotyped behaviors including freezing behaviors. These solid studies increase our understanding of brain pathways regulating these types of behaviors.

   Reviewed by eLife

10. Coordinated stimulation of axon regenerative and neurodegenerative transcriptional programs by ATF4 following optic nerve injury

    This article has 12 authors:

    1. Preethi Somasundaram
    2. Madeline M Farley
    3. Melissa A Rudy
    4. Katya Sigal
    5. Andoni I Asencor
    6. David G Stefanoff
    7. Malay Shah
    8. Puneetha Goli
    9. Jenny Heo
    10. Shufang Wang
    11. Nicholas M Tran
    12. Trent A Watkins

    This article has been curated by 1 group:

    • Curated by eLife

      eLife Assessment

      This study presents a valuable finding about the role of Perk (Protein kinase RNA-like endoplasmic reticulum kinase) and Atf4 (Activating Transcription Factor-4) in the integrated neurodegenerative and regenerative responses following the optic nerve injury. The authors present solid evidence, combining newly generated transcriptomic data with publicly available datasets to strengthen their findings. Despite some limitations in data quality and interpretation, the study is likely to be of interest to researchers studying optic neuropathies and axonal regeneration.

    Reviewed by eLife