eLife

Latest preprint reviews

1. β-cell intrinsic dynamics rather than gap junction structure dictates subpopulations in the islet functional network

   This article has 7 authors:

   1. Jennifer K Briggs
   2. Anne Gresch
   3. Isabella Marinelli
   4. JaeAnn M Dwulet
   5. David J Albers
   6. Vira Kravets
   7. Richard KP Benninger

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     The manuscript describes a set of detailed modeling and experimental studies to disentangle the respective roles of gap junctional electrical vs. metabolic coupling mechanisms in the synchronization of islet activity. This is of interest due to the importance of islet synchronization and generally islet network properties in the regulation of insulin secretion from the pancreas. The significance of the findings was judged to be mostly important and the strength of evidence provided was judged to be mostly solid overall.

   Reviewed by eLife

2. Continuous sensing of nutrients and growth factors by the mTORC1-TFEB axis

   This article has 6 authors:

   1. Breanne Sparta
   2. Nont Kosaisawe
   3. Michael Pargett
   4. Madhura Patankar
   5. Nicholaus DeCuzzi
   6. John G Albeck

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     In this study, Sparta et al., generated and employed a battery of fluorescent reporters that allowed them to perform time-resolved monitoring of mechanistic target of rapamycin complex 1 (mTORC1) responses to stimuli including glucose, amino acids, and insulin at the single cell resolution. The results of this elegant approach support a model of graded mTORC1 activation in response to the aforementioned stimuli when applied individually or in combination. This model is consistent with continuous adjustment of mTORC1 signaling to changes in cellular environment and opposed to the "on/off" model of mTORC1 function. Considering the pivotal role of mTORC1 in integrating signals such as nutrients, hormones, growth factors, oxygen, and energy status with a plethora of outputs that affect cell fate and organismal physiology, it was thought that this study will be of interests across a variety of biomedical disciplines. Overall, the elegance and robustness of the approach was highly appreciated, though the paper would be strengthened by addressing some technical issues and concerns regarding the positioning of the proposed model of mTORC1 regulation in the field.

   Reviewed by eLife

3. We couldn't get details of this article at this time:
   10.1101/2023.05.26.542486

4. We couldn't get details of this article at this time:
   10.21203/rs.3.rs-2567304/v2

5. We couldn't get details of this article at this time:
   10.1101/2023.08.24.554649

6. We couldn't get details of this article at this time:
   10.1101/2023.07.18.549469

7. Major patterns in the introgression history of Heliconius butterflies

   This article has 4 authors:

   1. Yuttapong Thawornwattana
   2. Fernando Seixas
   3. Ziheng Yang
   4. James Mallet

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important study revises the evolutionary history of Heliconius butterflies, a well-established model system for understanding speciation in the presence of gene flow between species. Using a convincing statistical phylogenetic approach that relies on the multispecies coalescent, the authors reconstruct the evolution of the lineage, including the timing of speciation events and the history of gene flow. The new phylogeny will be of interest to all researchers working on Heliconius butterflies, and the phylogenetic approach to investigators aiming to understand the history of lineages that have experienced extensive gene flow.

   Reviewed by eLife

8. We couldn't get details of this article at this time:
   10.1101/2023.05.31.543071

9. Fluorescein-based sensors to purify human α-cells for functional and transcriptomic analyses

   This article has 9 authors:

   1. Sevim Kahraman
   2. Kimitaka Shibue
   3. Dario F De Jesus
   4. Hyunki Kim
   5. Jiang Hu
   6. Debasish Manna
   7. Bridget Wagner
   8. Amit Choudhary
   9. Rohit N Kulkarni

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     The manuscript by Kahraman et al. describes the use of a fluorescent dye for purifying and analyzing human islet alpha cells. The study provides solid evidence that the alpha cells can be purified using this method and the cells remained viable and functional after culturing for several days. The significance of the study is access to a new tool that will be useful for islet biologists and researchers studying diabetes mechanisms.

   Reviewed by eLife

10. We couldn't get details of this article at this time:
    10.1101/2023.08.07.552220