eLife

Latest preprint reviews

1. C. difficile may be overdiagnosed in adults and is a prevalent commensal in infants

   This article has 19 authors:

   1. Pamela Ferretti
   2. Jakob Wirbel
   3. Oleksandr M Maistrenko
   4. Thea Van Rossum
   5. Renato Alves
   6. Anthony Fullam
   7. Wasiu Akanni
   8. Christian Schudoma
   9. Anna Schwarz
   10. Roman Thielemann
   11. Leonie Thomas
   12. Stefanie Kandels
   13. Rajna Hercog
   14. Anja Telzerow
   15. Ivica Letunic
   16. Michael Kuhn
   17. Georg Zeller
   18. Thomas SB Schmidt
   19. Peer Bork

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important study points out discrepancies between the clinical diagnosis of Clostridioides difficile infection and the lack of detectable C. difficile in gut microbiome samples, as well as different relationships between asymptomatic C. difficile carriage and adult or infant gut microbiota compositions. While the solid analysis of a comprehensive and diverse metagenomic dataset suggests an over-diagnosis of C. difficile infection and an under-diagnosis of other putative enteric pathogens, the work requires addressing the detection limitations of the approach to be more convincing. This work will interest microbiologists and clinicians concerned with understanding the role of C. difficile in gut microbiota health and dysbiosis.

   Reviewed by eLife

2. Heterogeneous presynaptic receptive fields contribute to directional tuning in starburst amacrine cells

   This article has 4 authors:

   1. John A Gaynes
   2. Samuel A Budoff
   3. Michael J Grybko
   4. Alon Poleg-Polsky

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important study uses a combination of computational modeling and glutamate imaging to show how a particular synaptic organization referred to as space-time wiring contributes minimally to a dendritic computation that occurs in the retina. The evidence supporting the claims of the authors is compelling, incorporating new findings regarding dynamic receptive field properties, an improvement over previous modeling and experimental results based on static visual stimuli. The work will be of interest to retinal neurobiologists and neurophysiologists interested in dendritic computations.

   Reviewed by eLife

3. We couldn't get details of this article at this time:
   10.1101/2023.07.25.550600

4. We couldn't get details of this article at this time:
   10.1101/2023.06.09.544329

5. We couldn't get details of this article at this time:
   10.1101/2023.04.19.537448

6. Spectrally and temporally resolved estimation of neural signal diversity

   This article has 8 authors:

   1. Pedro A.M. Mediano
   2. Fernando E. Rosas
   3. Andrea I. Luppi
   4. Valdas Noreika
   5. Anil K. Seth
   6. Robin L. Carhart-Harris
   7. Lionel Barnett
   8. Daniel Bor

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This paper describes a new complexity estimator for time series based on state-space modeling, which can directly decompose signal entropy in both time and frequency. The authors compare their estimator to Lempel-Ziv (LZ) complexity using a variety of time series neurophysiological data from humans and non-human primates. This represents a potentially valuable methodological contribution for existing studies using LZ complexity in their analyses, although the paper currently ignores much of the existing literature which has already developed related solutions to the same issues. The strength of the evidence supporting the superiority of the new complexity metric is currently incomplete, and should be backed by additional analyses.

   Reviewed by eLife

7. We couldn't get details of this article at this time:
   10.1101/2023.03.26.534245

8. Gradient organisation of functional connectivity within resting state networks is present from 25 weeks gestation in the human fetal brain

   This article has 15 authors:

   1. Jucha Willers Moore
   2. Siân Wilson
   3. Marianne Oldehinkel
   4. Lucilio Cordero-Grande
   5. Alena Uus
   6. Vanessa Kyriakopoulou
   7. Eugene P Duff
   8. Jonathan O’Muircheartaigh
   9. Mary A Rutherford
   10. Laura C Andreae
   11. Joseph V Hajnal
   12. A David Edwards
   13. Christian F Beckmann
   14. Tomoki Arichi
   15. Vyacheslav R Karolis

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study presents important findings indicating that gradients of functional connectivity are present in the human foetal brain, and that these gradients develop further during gestation, particularly in multisensory brain regions. The study uses state-of-the-art connectomic mapping techniques. However, recent findings suggest that such gradients may reflect confounds within the analysis technique more than underlying brain functions. The evidence for the authors' claims therefore currently appears inadequate as it does not account for these potential confounds.

   Reviewed by eLife

9. We couldn't get details of this article at this time:
   10.1101/2023.06.22.546068

10. We couldn't get details of this article at this time:
    10.1101/2023.06.01.543205