eLife

Latest preprint reviews

1. Baited reconstruction with 2D template matching for high-resolution structure determination in vitro and in vivo without template bias

   This article has 3 authors:

   1. Bronwyn A Lucas
   2. Benjamin A Himes
   3. Nikolaus Grigorieff

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This is an important demonstration of how the false-positive rate of high-resolution 2D template matching to find particles of a given target structure in 2D cryo-EM images (2DTM) relates to overfitting the data towards the template. The authors present new methods to measure the amount of model bias that gets introduced in high-resolution features of such maps, with compelling evidence that high-resolution features that are not present in the template can still be reconstructed in 3D from images obtained by 2DTM.

   Reviewed by eLife

2. We couldn't get details of this article at this time:
   10.1101/2023.06.14.544980

3. Identification of key yeast species and microbe–microbe interactions impacting larval growth of Drosophila in the wild

   This article has 16 authors:

   1. Ayumi Mure
   2. Yuki Sugiura
   3. Rae Maeda
   4. Kohei Honda
   5. Nozomu Sakurai
   6. Yuuki Takahashi
   7. Masayoshi Watada
   8. Toshihiko Katoh
   9. Aina Gotoh
   10. Yasuhiro Gotoh
   11. Itsuki Taniguchi
   12. Keiji Nakamura
   13. Tetsuya Hayashi
   14. Takane Katayama
   15. Tadashi Uemura
   16. Yukako Hattori

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This is an important study that addresses a significant question in microbiome research. The authors provide convincing evidence that certain bacterial groups within the fly microbiome have critical functions for host development. Additionally, dietary aspects such as microbial community progression in a natural food source are integrated into their host-microbe interaction analyses.

   Reviewed by eLife

4. RNA-binding deficient TDP-43 drives cognitive decline in a mouse model of TDP-43 proteinopathy

   This article has 17 authors:

   1. Julie C Necarsulmer
   2. Jeremy M Simon
   3. Baggio A Evangelista
   4. Youjun Chen
   5. Xu Tian
   6. Sara Nafees
   7. Ariana B Marquez
   8. Huijun Jiang
   9. Ping Wang
   10. Deepa Ajit
   11. Viktoriya D Nikolova
   12. Kathryn M Harper
   13. J Ashley Ezzell
   14. Feng-Chang Lin
   15. Adriana S Beltran
   16. Sheryl S Moy
   17. Todd J Cohen

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     Necarsulmer et al describe an interesting new mouse model of TDP-43 proteinopathy in which gene editing was used to introduce a K145Q acetylation-mimic mutation previously shown to impair RNA-binding capacity and induce downstream misregulation of target genes. Mice homozygous for this mutation are convincingly shown to display cognitive/behavioral impairment, TDP-43 phosphorylation and insolubility, and changes in gene expression and splicing. This novel mouse model replicates some key hallmarks of human frontotemporal lobar degeneration and will be an important contribution to the field.

   Reviewed by eLife

5. We couldn't get details of this article at this time:
   10.1101/2023.07.25.550597

6. We couldn't get details of this article at this time:
   10.1101/2023.07.21.549992

7. We couldn't get details of this article at this time:
   10.1101/2023.05.10.539968

8. We couldn't get details of this article at this time:
   10.1101/2022.10.13.512183

9. We couldn't get details of this article at this time:
   10.1101/2023.06.24.546394

10. We couldn't get details of this article at this time:
    10.1101/2023.06.16.545247