eLife

Latest preprint reviews

1. Mouse gingival single-cell transcriptomic atlas identified a novel fibroblast subpopulation activated to guide oral barrier immunity in periodontitis

   This article has 5 authors:

   1. Takeru Kondo
   2. Annie Gleason
   3. Hiroko Okawa
   4. Akishige Hokugo
   5. Ichiro Nishimura

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     The findings of this article provide valuable information on the changes of cell clusters induced by chronic periodontitis. The observation of a new fibroblast subpopulation, named AG fibroblasts, is interesting, and the strength of evidence presented is solid.

   Reviewed by eLife

2. De novo fatty-acid synthesis protects invariant NKT cells from cell death, thereby promoting their homeostasis and pathogenic roles in airway hyperresponsiveness

   This article has 11 authors:

   1. Jaemoon Koh
   2. Yeon Duk Woo
   3. Hyun Jung Yoo
   4. Jun-Pyo Choi
   5. Sae Hoon Kim
   6. Yoon-Seok Chang
   7. Kyeong Cheon Jung
   8. Ji Hyung Kim
   9. Yoon Kyung Jeon
   10. Hye Young Kim
   11. Doo Hyun Chung

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     The study's results offer a fundamental insight into how ACC1-mediated fatty-acid synthesis affects the survival and pathogenicity of iNKT cells in allergic asthma. The inclusion of mouse models, involving genetic adjustments and reconstitution experiments, along with the disparities found in iNKT cells between allergic asthma patients and control subjects in human studies, adds compelling evidence that substantiates these findings.

   Reviewed by eLife

3. Adenylnucleotide-mediated binding of the PII-like protein SbtB contributes to controlling activity of the cyanobacterial bicarbonate transporter SbtA

   This article has 6 authors:

   1. Britta Förster
   2. Bratati Mukherjee
   3. Loraine M. Rourke
   4. Joe A. Kaczmarski
   5. Colin J. Jackson
   6. G. Dean Price

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study is of fundamental importance, addressing the regulation of the carbon concentrating mechanism in cyanobacteria. It is a well-controlled investigation of low affinity regulatory binding of small molecules, processes that are typically difficult to examine. The work provides compelling evidence that the adenylate pool, rather than any single metabolite, regulates a key bicarbonate transporter (SbtA) to provide efficient bicarbonate supply while preventing futile cycling that can result from escape of unfixed CO2.

   Reviewed by eLife

4. The yeast RNA methylation complex consists of conserved yet reconfigured components with m6A-dependent and independent roles

   This article has 16 authors:

   1. Imke Ensinck
   2. Alexander Maman
   3. Waleed S Albihlal
   4. Michelangelo Lassandro
   5. Giulia Salzano
   6. Theodora Sideri
   7. Steven A Howell
   8. Enrica Calvani
   9. Harshil Patel
   10. Guy Bushkin
   11. Markus Ralser
   12. Ambrosius P Snijders
   13. Mark Skehel
   14. Ana Casañal
   15. Schraga Schwartz
   16. Folkert J van Werven

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This fundamental study identifies the components of the N6-methyladenosine methyltransferase complexes in yeasts, with major differences with the same complexes in mammals and flies. The evidence supporting the conclusions is convincing, with rigorous high-throughput sequencing approaches and detailed functional analysis. This work will be of broad interest to colleagues in the RNA modification and meiosis fields.

   Reviewed by eLife

5. Adolescent neurostimulation of dopamine circuit reverses genetic deficits in frontal cortex function

   This article has 10 authors:

   1. Surjeet Mastwal
   2. Xinjian Li
   3. Rianne Stowell
   4. Matthew Manion
   5. Wenyu Zhang
   6. Nam-Shik Kim
   7. Ki-Jun Yoon
   8. Hongjun Song
   9. Guo-Li Ming
   10. Kuan Hong Wang

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This is an important study that addresses the interesting question of whether stimulation of DA input to prefrontal cortex during adolescence can be used to rescue genetic defects on DA regulation of PFC function. The conclusions are convincingly supported by the data together with discussion of some limitations of the approach. This story will of interest to a broad group of neuroscientists interested in regulation of prefrontal cortical function in behavior.

   Reviewed by eLife

6. Catecholaminergic neuromodulation and selective attention jointly shape perceptual decision-making

   This article has 5 authors:

   1. Stijn A Nuiten
   2. Jan Willem de Gee
   3. Jasper B Zantvoord
   4. Johannes J Fahrenfort
   5. Simon van Gaal

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important study shows that pharmacologically enhanced catecholamine levels and increased voluntary spatial attention have overlapping as well as dissociable effects on performance on a visuospatial attention task and corresponding EEG markers. The findings provide solid evidence regarding how neuromodulatory arousal and selective spatial attention jointly shape perceptional decision-making.

   Reviewed by eLife

7. Mechanistic and evolutionary insights into isoform-specific ‘supercharging’ in DCLK family kinases

   This article has 15 authors:

   1. Aarya Venkat
   2. Grace Watterson
   3. Dominic P Byrne
   4. Brady O'Boyle
   5. Safal Shrestha
   6. Nathan Gravel
   7. Emma E Fairweather
   8. Leonard A Daly
   9. Claire Bunn
   10. Wayland Yeung
   11. Ishan Aggarwal
   12. Samiksha Katiyar
   13. Claire E Eyers
   14. Patrick A Eyers
   15. Natarajan Kannan

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important study expands on current knowledge of allosteric diversity in the human kinome by C-terminal splicing variants using as a paradigm DCLK1. The authors provide convincing evolutionary and some mechanistic evidence how C-terminal isoform specific variants generated by alternative splicing can regulate catalytic activity by means of coupling specific phosphorylation sites to dynamical and conformational changes controlling active site and substrate pocket occupancy, as well as protein-protein interactions. The data will be of interest to researchers in the kinase and signal transduction field.

   Reviewed by eLife

8. Five years later, with double the demographic data, naked mole-rat mortality rates continue to defy Gompertzian laws by not increasing with age

   This article has 3 authors:

   1. J. Graham Ruby
   2. Megan Smith
   3. Rochelle Buffenstein

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This useful study aims to characterize patterns of demographic aging in naked mole rats by quantifying mortality rates in a captive colony, up to approximately the median age of death. The study system is a fascinating case of unusual longevity and physiology in mammals, but because of limited sampling at older ages and missing analyses, the evidence for the main conclusion – that naked mole rats do not experience actuarial senescence – is incomplete for younger animals and inadequate for older animals. The work nevertheless provides data of interest to biodemographers and biomedical researchers interested in naked mole rats as a model for aging.

   Reviewed by eLife

9. Broad functional profiling of fission yeast proteins using phenomics and machine learning

   This article has 9 authors:

   1. María Rodríguez-López
   2. Nicola Bordin
   3. Jon Lees
   4. Harry Scholes
   5. Shaimaa Hassan
   6. Quentin Saintain
   7. Stephan Kamrad
   8. Christine Orengo
   9. Jürg Bähler

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important study combines extensive phenotyping of genome-wide deletion mutants and machine learning-based prediction to generate a large scale resource for understanding the functions of thousands of fission yeast protein-coding genes. This resource is supported by convincing phenotyping data and state-of-the-art bioinformatic analyses and will be of interest to many geneticists.

   Reviewed by eLife

10. Disulfide bridge-dependent dimerization triggers FGF2 membrane translocation into the extracellular space

    This article has 18 authors:

    1. Fabio Lolicato
    2. Julia P Steringer
    3. Roberto Saleppico
    4. Daniel Beyer
    5. Jaime Fernandez-Sobaberas
    6. Sebastian Unger
    7. Steffen Klein
    8. Petra Riegerová
    9. Sabine Wegehingel
    10. Hans-Michael Müller
    11. Xiao J Schmitt
    12. Shreyas Kaptan
    13. Christian Freund
    14. Martin Hof
    15. Radek Šachl
    16. Petr Chlanda
    17. Ilpo Vattulainen
    18. Walter Nickel

    This article has been curated by 1 group:

    • Curated by eLife

      eLife assessment

      This manuscript reports important findings, demonstrating a critical role for a cysteine-containing dimerization interface in the secretion of FGF2 through an unconventional pathway. The authors provide compelling evidence, combining in vitro biochemical assays with structural simulation. The work will be of interest to researchers working on protein trafficking and secretion.

    Reviewed by eLife