eLife

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1. The cation channel mechanisms of subthreshold inward depolarizing currents in the mice VTA dopaminergic neurons and their roles in the chronic-stress-induced depression-like behavior

   This article has 11 authors:

   1. Jing Wang
   2. Min Su
   3. Dongmei Zhang
   4. Ludi Zhang
   5. Chenxu Niu
   6. Chaoyi Li
   7. Shuangzhu You
   8. Yuqi Sang
   9. Yongxue Zhang
   10. Xiaona Du
   11. Hailin Zhang

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important study examined the mechanisms underlying reduced excitability of ventral tegmental area dopamine neurons in mice that underwent a chronic mild unpredictable stress treatment. The authors identify NALCN and TRPC6 channels as key mechanisms that regulate spontaneous firing of ventral tegmental area dopamine neurons and examined their roles in reduced firing in mice that underwent a chronic mild unpredictable stress treatment. The authors' conclusions on neurophysiological data are supported by multiple approaches and are convincing, although the relevance of the behavioral results to human depression remains unclear.

   Reviewed by eLife

2. A Pvr–AP-1–Mmp1 signaling pathway is activated in astrocytes upon traumatic brain injury

   This article has 4 authors:

   1. Tingting Li
   2. Wenwen Shi
   3. Margaret S Ho
   4. Yong Q Zhang

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study represents a valuable finding on the neuron-glia communication and glial responses to traumatic brain injury (TBI). The data supporting the authors' conclusions on TBI analysis, RNA-seq on FACS sorted astrocytes, genetic analyses on Pvr-JNK/MMP1 are solid. However, cellular aspects of the response to TBI, statistical analysis, and molecular links between Pvr-AP1 are incomplete, which could be further strengthened in the future by more rigorous analyses.

   Reviewed by eLife

3. TLR7 activation at epithelial barriers promotes emergency myelopoiesis and lung antiviral immunity

   This article has 10 authors:

   1. William D Jackson
   2. Chiara Giacomassi
   3. Sophie Ward
   4. Amber Owen
   5. Tiago C Luis
   6. Sarah Spear
   7. Kevin J Woollard
   8. Cecilia Johansson
   9. Jessica Strid
   10. Marina Botto

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important work advances our understanding of TLR7 signaling at epithelial surfaces that drives monocytes expansion and its impact on viral responses. The evidence supporting this conclusion is solid, particularly data demonstrating TLR7 stimulation and the requirement for TLR7 in the monocyte expansion. The work will be of interest to immunologists and virologists.

   Reviewed by eLife

4. Conformational regulation and target-myristoyl switch of calcineurin B homologous protein 3

   This article has 14 authors:

   1. Florian Becker
   2. Simon Fuchs
   3. Lukas Refisch
   4. Friedel Drepper
   5. Wolfgang Bildl
   6. Uwe Schulte
   7. Shuo Liang
   8. Jonas Immanuel Heinicke
   9. Sierra C Hansen
   10. Clemens Kreutz
   11. Bettina Warscheid
   12. Bernd Fakler
   13. Evgeny V Mymrikov
   14. Carola Hunte

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     In this work, the authors provide important mechanistic insights into how the intracellular effector protein Calcineurin B homologous protein 3 (CHP3) can be regulated in a calcium-independent manner to expose its lipid binding site. Compelling evidence demonstrates a binding partner protein (NHE1) triggers a conformation change and exposure of the myristoyl group in CHP3 resulting in membrane association. This provides mechanistic insight into the signalling mechanisms achieved by CHP3 in a target-dependent manner, which will be of broad scientific interest.

   Reviewed by eLife

5. Global diversity and antimicrobial resistance of typhoid fever pathogens: Insights from a meta-analysis of 13,000 Salmonella Typhi genomes

   This article has 115 authors:

   1. Megan E Carey
   2. Zoe A Dyson
   3. Danielle J Ingle
   4. Afreenish Amir
   5. Mabel K Aworh
   6. Marie Anne Chattaway
   7. Ka Lip Chew
   8. John A Crump
   9. Nicholas A Feasey
   10. Benjamin P Howden
   11. Karen H Keddy
   12. Mailis Maes
   13. Christopher M Parry
   14. Sandra Van Puyvelde
   15. Hattie E Webb
   16. Ayorinde Oluwatobiloba Afolayan
   17. Anna P Alexander
   18. Shalini Anandan
   19. Jason R Andrews
   20. Philip M Ashton
   21. Buddha Basnyat
   22. Ashish Bavdekar
   23. Isaac I Bogoch
   24. John D Clemens
   25. Kesia Esther da Silva
   26. Anuradha De
   27. Joep de Ligt
   28. Paula Lucia Diaz Guevara
   29. Christiane Dolecek
   30. Shanta Dutta
   31. Marthie M Ehlers
   32. Louise Francois Watkins
   33. Denise O Garrett
   34. Gauri Godbole
   35. Melita A Gordon
   36. Andrew R Greenhill
   37. Chelsey Griffin
   38. Madhu Gupta
   39. Rene S Hendriksen
   40. Robert S Heyderman
   41. Yogesh Hooda
   42. Juan Carlos Hormazabal
   43. Odion O Ikhimiukor
   44. Junaid Iqbal
   45. Jobin John Jacob
   46. Claire Jenkins
   47. Dasaratha Ramaiah Jinka
   48. Jacob John
   49. Gagandeep Kang
   50. Abdoulie Kanteh
   51. Arti Kapil
   52. Abhilasha Karkey
   53. Samuel Kariuki
   54. Robert A Kingsley
   55. Roshine Mary Koshy
   56. AC Lauer
   57. Myron M Levine
   58. Ravikumar Kadahalli Lingegowda
   59. Stephen P Luby
   60. Grant Austin Mackenzie
   61. Tapfumanei Mashe
   62. Chisomo Msefula
   63. Ankur Mutreja
   64. Geetha Nagaraj
   65. Savitha Nagaraj
   66. Satheesh Nair
   67. Take K Naseri
   68. Susana Nimarota-Brown
   69. Elisabeth Njamkepo
   70. Iruka N Okeke
   71. Sulochana Putli Bai Perumal
   72. Andrew J Pollard
   73. Agila Kumari Pragasam
   74. Firdausi Qadri
   75. Farah N Qamar
   76. Sadia Isfat Ara Rahman
   77. Savitra Devi Rambocus
   78. David A Rasko
   79. Pallab Ray
   80. Roy Robins-Browne
   81. Temsunaro Rongsen-Chandola
   82. Jean Pierre Rutanga
   83. Samir K Saha
   84. Senjuti Saha
   85. Karnika Saigal
   86. Mohammad Saiful Islam Sajib
   87. Jessica C Seidman
   88. Jivan Shakya
   89. Varun Shamanna
   90. Jayanthi Shastri
   91. Rajeev Shrestha
   92. Sonia Sia
   93. Michael J Sikorski
   94. Ashita Singh
   95. Anthony M Smith
   96. Kaitlin A Tagg
   97. Dipesh Tamrakar
   98. Arif Mohammed Tanmoy
   99. Maria Thomas
   100. Mathew S Thomas
   101. Robert Thomsen
   102. Nicholas R Thomson
   103. Siaosi Tupua
   104. Krista Vaidya
   105. Mary Valcanis
   106. Balaji Veeraraghavan
   107. François-Xavier Weill
   108. Jackie Wright
   109. Gordon Dougan
   110. Silvia Argimón
   111. Jacqueline A Keane
   112. David M Aanensen
   113. Stephen Baker
   114. Kathryn E Holt
   115. Global Typhoid Genomics Consortium Group Authorship

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     Although largely descriptive, this meta-analysis of 13,000 published Typhi genomes is hugely important to public health. The dataset and presented analysis represents the first wholesale analysis of all available Typhi genomes from the last 21 years. The findings are of great significance to tracking the emergence and maintenance of AMR in Typhi and include novel insights into XDR strain emergence in Pakistan as well as the relationship between MDR maintenance and chromosomal integration.

   Reviewed by eLife

6. How enhancers regulate wavelike gene expression patterns

   This article has 9 authors:

   1. Christine Mau
   2. Heike Rudolf
   3. Frederic Strobl
   4. Benjamin Schmid
   5. Timo Regensburger
   6. Ralf Palmisano
   7. Ernst HK Stelzer
   8. Leila Taher
   9. Ezzat El-Sherif

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     The authors describe a sophisticated method to follow enhancer activity in both live embryos and fixed embryos in Tribolium and present important data about the function of a number of enhancers in early development. They show that some of the enhancers are "dynamic" and others are "static" and use this to provide support for the "enhancer-switching" model of gene regulation suggested by some of these authors in the past. However, the evidence they provide is incomplete and although it is consistent with the model, it does not directly support it.

   Reviewed by eLife

7. Plant secondary metabolite-dependent plant-soil feedbacks can improve crop yield in the field

   This article has 11 authors:

   1. Valentin Gfeller
   2. Jan Waelchli
   3. Stephanie Pfister
   4. Gabriel Deslandes-Hérold
   5. Fabio Mascher
   6. Gaetan Glauser
   7. Yvo Aeby
   8. Adrien Mestrot
   9. Christelle AM Robert
   10. Klaus Schlaeppi
   11. Matthias Erb

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study presents findings that are important for understanding plant-soil feedbacks in agriculture. The authors use a large-scale agricultural field experiment to demonstrate the role of root-emitted secondary metabolites in enhancing the yield of the next crop. By using a benzoxazinoid-deficient maize genotype, the authors provide compelling evidence that biomass production and grain yield of several wheat varieties can be increased when grown in soil conditioned by maize plants able to release benzoxazinoids.

   Reviewed by eLife

8. Agonist efficiency links binding and gating in a nicotinic receptor

   This article has 2 authors:

   1. Dinesh C Indurthi
   2. Anthony Auerbach

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This valuable work investigates the fundamental concept of how the energy of agonist binding is converted into the energy of the conformational change that opens the pore of a ligand-gated ion channel. The conclusions are based on analysis of solid data in terms of a mechanistic model, but adequate statistical analysis is lacking and the uniqueness of the proposed model is not discussed. The findings will be interesting to biophysicists working on ligand-gated ion channels and, more generally, to enzymologists focused on allosteric enzyme regulation.

   Reviewed by eLife

9. Large-scale neural dynamics in a shared low-dimensional state space reflect cognitive and attentional dynamics

   This article has 3 authors:

   1. Hayoung Song
   2. Won Mok Shim
   3. Monica D Rosenberg

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This valuable study examines the distribution of four states of brain activity across a variety of cognitive conditions, linking systems neuroscience with cognition and behavior. The work is convincing, using null models and replication in independent datasets to support their findings.

   Reviewed by eLife

10. Low-level repressive histone marks fine-tune gene transcription in neural stem cells

    This article has 9 authors:

    1. Arjun Rajan
    2. Lucas Anhezini
    3. Noemi Rives-Quinto
    4. Jay Y Chhabra
    5. Megan C Neville
    6. Elizabeth D Larson
    7. Stephen F Goodwin
    8. Melissa M Harrison
    9. Cheng-Yu Lee

    This article has been curated by 1 group:

    • Curated by eLife

      eLife assessment

      This important work shows how a transcription factor, fruitless isoform C, fine-tunes the expression of stemness genes to maintain proper stem-cell identity during neurogenesis in Drosophila. The rationale of the work is well-thought-out, conclusions are supported by compelling evidence, and experiments are performed in a rigorous manner, although additional statistics would improve the conclusions. Overall, this work will be of interest to those working on chromatin regulation, transcription regulation, and stem-cell biology.

    Reviewed by eLife