eLife

Latest preprint reviews

1. A rapid review of COVID-19’s global impact on breast cancer screening participation rates and volumes from January to December 2020

   This article has 7 authors:

   1. Reagan Lee
   2. Wei Xu
   3. Marshall Dozier
   4. Ruth McQuillan
   5. Evropi Theodoratou
   6. Jonine Figueroa
   7. On Behalf of UNCOVER and the International Partnership for Resilience in CancerSystems (I-PaRCS), Breast Cancer Working Group 2

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study presents important evidence of the impact of the covid pandemic on breast cancer screening globally but with important variations by healthcare setting. The data analysis is comprehensive, using solid systematic review methods. The results will be of interest to public health policymakers and health care and cancer control practitioners and researchers across the globe.

   Reviewed by eLife

2. Isoform-specific disruption of the TP73 gene reveals a critical role for TAp73γ in tumorigenesis via leptin

   This article has 10 authors:

   1. Xiangmudong Kong
   2. Wensheng Yan
   3. Wenqiang Sun
   4. Yanhong Zhang
   5. Hee Jung Yang
   6. Mingyi Chen
   7. Hongwu Chen
   8. Ralph W de Vere White
   9. Jin Zhang
   10. Xinbin Chen

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     TP73 is a member of the p53 family of tumor suppressors. The authors provide compelling evidence that a TAp73-alpha to TAp73-gamma switch could be a frequent phenomenon in human cancers and provide novel evidence that TAp73-gamma has oncogenic functions via Leptin. The authors provide a substantial amount of high-quality data and convincingly demonstrate a novel function of this specific isoform of p73 in lipid metabolism and tumorigenesis.

   Reviewed by eLife

3. Id2 GABAergic interneurons comprise a neglected fourth major group of cortical inhibitory cells

   This article has 11 authors:

   1. Robert Machold
   2. Shlomo Dellal
   3. Manuel Valero
   4. Hector Zurita
   5. Ilya Kruglikov
   6. John Hongyu Meng
   7. Jessica L Hanson
   8. Yoshiko Hashikawa
   9. Benjamin Schuman
   10. György Buzsáki
   11. Bernardo Rudy

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This is a valuable contribution to the effort to provide genetic access to and characterization of the major classes of interneurons in the mammalian neocortex. The authors develop an improved strategy for intersectionally targeting a fourth (and final) major category of diverse interneurons in the mouse, including the previously studied neurogliaform cells. They provide a detailed characterization of these cells and show convincingly that their genetic strategy can be used to identify and manipulate these cells, both in vitro and in vivo.

   Reviewed by eLife

4. Scavenger receptor endocytosis controls apical membrane morphogenesis in the Drosophila airways

   This article has 5 authors:

   1. Ana Sofia Pinheiro
   2. Vasilios Tsarouhas
   3. Kirsten André Senti
   4. Badrul Arefin
   5. Christos Samakovlis

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     In this important study, the authors present evidence for the novel involvement of a scavenger receptor in tubular morphogenesis. Using a convincing set of data, the authors propose that the Drosophila scavenger receptor Emp (homologous to human CD36 ) couples endocytosis of luminal molecules and regulates tube length via controlling Crumbs and Src. This work will be of broad interest to cell and development biologists as well as cancer biologists.

   Reviewed by eLife

5. Manganese-enhanced magnetic resonance imaging reveals light-induced brain asymmetry in embryo

   This article has 4 authors:

   1. Elena Lorenzi
   2. Stefano Tambalo
   3. Giorgio Vallortigara
   4. Angelo Bifone

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This manuscript is important as it showed an establishment of a method for looking a neuronal activity in embryos which can support the previously reported laterality in chick thalamofugal system. However, the evidence the author provided was incomplete as no actual data was provided.

   Reviewed by eLife

6. Divergent regulation of KCNQ1/E1 by targeted recruitment of protein kinase A to distinct sites on the channel complex

   This article has 6 authors:

   1. Xinle Zou
   2. Sri Karthika Shanmugam
   3. Scott A Kanner
   4. Kevin J Sampson
   5. Robert S Kass
   6. Henry M Colecraft

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important study provides a substantial advance with a method by which a protein target resistant to therapeutic approaches can be uniquely modulated by a cellular protein kinase ferried by nanobodies to a precise molecular site of recruitment. Evidence for this major claim is compelling, but evidence for some of the minor claims seems incomplete. The work will be of broad interest to cell biologists, cardiovascular researchers, and drug developers.

   Reviewed by eLife

7. Using multi-modal neuroimaging to characterise social brain specialisation in infants

   This article has 8 authors:

   1. Maheen Siddiqui
   2. Paola Pinti
   3. Sabrina Brigadoi
   4. Sarah Lloyd-Fox
   5. Clare E Elwell
   6. Mark H Johnson
   7. Ilias Tachtsidis
   8. Emily JH Jones

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important study provides a state-of-the-art framework to explore the coupling of complementary cerebral measures (neural, hemodynamic, and metabolic) during development by providing an interesting roadmap for multimodal neuroimaging in infants. The methodological contribution is compelling with an original setup for simultaneous EEG and NIRS recording and solid data analyses. However, the claims about functional specialization and the role of the temporal-parietal junction in social processing are only partially supported by the results. This work will be of interest to a broad audience of scientists interested in multimodal neuroimaging and cognitive development.

   Reviewed by eLife

8. CD8+ tissue-resident memory T cells induce oral lichen planus erosion via cytokine network

   This article has 11 authors:

   1. Maofeng Qing
   2. Dan Yang
   3. Qianhui Shang
   4. Jiakuan Peng
   5. Jiaxin Deng
   6. Jiang Lu
   7. Jing Li
   8. HongXia Dan
   9. Yu Zhou
   10. Hao Xu
   11. Qianming Chen

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     Overall, this is an important study that characterizes human oral lichen planus via single-cell analysis. Although the work is descriptive, it can represent an important resource for future studies and highlights potentially relevant biology. However, the claims are a bit overstated and some of the analyses that lead to interpretations remain incomplete.

   Reviewed by eLife

9. Fin whale song evolution in the North Atlantic

   This article has 17 authors:

   1. Miriam Romagosa
   2. Sharon Nieukirk
   3. Irma Cascão
   4. Tiago A Marques
   5. Robert Dziak
   6. Jean-Yves Royer
   7. Joanne O'Brien
   8. David K Mellinger
   9. Andreia Pereira
   10. Arantza Ugalde
   11. Elena Papale
   12. Sofia Aniceto
   13. Giuseppa Buscaino
   14. Marianne Rasmussen
   15. Luis Matias
   16. Rui Prieto
   17. Mónica A Silva

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study is a valuable contribution to our understanding of vocal variation in acoustic displays of male baleen whales, part of a developing story about cultural change in songs in species other than the relatively well studied humpback whales. The authors present solid evidence of changes at various timescales in 20-Hz song note intervals and call center frequency over decadal time scales and large spatial scales.

   Reviewed by eLife

10. Folding of prestin’s anion-binding site and the mechanism of outer hair cell electromotility

    This article has 6 authors:

    1. Xiaoxuan Lin
    2. Patrick R Haller
    3. Navid Bavi
    4. Nabil Faruk
    5. Eduardo Perozo
    6. Tobin R Sosnick

    This article has been curated by 1 group:

    • Curated by eLife

      eLife assessment

      This study presents important findings regarding the local dynamics at the anion binding site in the SLC26 transporter prestin that is responsible for electromotility in outer hair cells. The authors reveal critical differences to homologous proteins and thereby provide insight into prestin's unique function. The evidence is generally convincing, although orthogonal evidence would be required to fully support the claims concerning the mechanistic basis for voltage sensitivity.

    Reviewed by eLife