eLife

Latest preprint reviews

1. Protein arginine methyltransferase 5 (Prmt5) localizes to chromatin loop anchors and modulates expression of genes at TAD boundaries during early adipogenesis

   This article has 6 authors:

   1. Sabriya A. Syed
   2. Kristina Shqillo
   3. Ankita Nand
   4. Ye Zhan
   5. Job Dekker
   6. Anthony N. Imbalzano

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     How the genome is folded three dimensionally is thought to control gene regulatory pathways during critical processes such as cellular differentiation. Using multiple assays, the authors of this important study probe topologically associated domains (TADs) and report involvement of a protein arginine methyltransferase 5 in chromatin organization and transcriptional regulation. The data gathered are generally solid and broadly support the role of this protein in organization of the adipocytic lineage, but additional control experiments would make the inferences stronger.

   Reviewed by eLife

2. We couldn't get details of this article at this time:
   10.1101/2023.03.28.534635

3. We couldn't get details of this article at this time:
   10.1101/2023.05.25.542308

4. Predicting ventricular tachycardia circuits in patients with arrhythmogenic right ventricular cardiomyopathy using genotype-specific heart digital twins

   This article has 12 authors:

   1. Yingnan Zhang
   2. Kelly Zhang
   3. Adityo Prakosa
   4. Cynthia James
   5. Stefan L Zimmerman
   6. Richard Carrick
   7. Eric Sung
   8. Alessio Gasperetti
   9. Crystal Tichnell
   10. Brittney Murray
   11. Hugh Calkins
   12. Natalia A Trayanova

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important study brings together a clear application of the digital twin approach to make predictions using patient specific models with different genotypes. The data are compelling and go beyond the current state-of-the-art to support proof-of-principle evidence. Given the low subject numbers, further studies will be required going forward to support the veracity of the data and its translational utility.

   Reviewed by eLife

5. Cell type-specific contributions to a persistent aggressive internal state in female Drosophila

   This article has 8 authors:

   1. Hui Chiu
   2. Alice A Robie
   3. Kristin Branson
   4. Tanvi Vippa
   5. Samantha Epstein
   6. Gerald M Rubin
   7. David J Anderson
   8. Catherine E Schretter

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study by Chiu and colleagues is a valuable contribution to the study of the circuitry of aggressive behaviours and of mechanisms that generate persistent behavioural states. The authors find that activation of two interconnected sets of neurons results in an increase in female aggression. The data ruling out recurrent connectivity between these clusters underlying this persistent state are convincing.

   Reviewed by eLife

6. Task-anchored grid cell firing is selectively associated with successful path integration-dependent behaviour

   This article has 2 authors:

   1. Harry Clark
   2. Matthew F Nolan

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This valuable study examines the relationship between positional anchoring of grid cell activity and performance in spatial navigation tasks that requires path integration. The authors demonstrate that grid cells can either fire in relation to the position relative to task-relevant virtual stimuli or independently based on the distance covered. Their findings convincingly reveal that mice exhibited better performance in the path integration task when grid cell activity was anchored to their position on the virtual track rather than the distance traversed, highlighting the contribution of grid firing to spatial navigation behavior. The work will be of interest to experimental and computational neuroscientists interested in spatial navigation.

   Reviewed by eLife

7. We couldn't get details of this article at this time:
   10.1101/2023.04.19.537477

8. The structural repertoire of Fusarium oxysporum f. sp. lycopersici effectors revealed by experimental and computational studies

   This article has 11 authors:

   1. Daniel S Yu
   2. Megan A Outram
   3. Ashley Smith
   4. Carl L McCombe
   5. Pravin B Khambalkar
   6. Sharmin A Rima
   7. Xizhe Sun
   8. Lisong Ma
   9. Daniel J Ericsson
   10. David A Jones
   11. Simon J Williams

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study provides important new insights into the structural diversity of effectors – proteins secreted by pathogens and symbionts into host cells – from the plant-associated fungus Fusarium oxysporum f. sp. lycopersici. The study provides a convincing approach to elucidate how effectors navigate their host environment by exploiting both computational and experimental approaches to understand how their structure influences binding partners. The work will be of interest to those studying molecular host-microbe interactions and disease protection.

   Reviewed by eLife

9. We couldn't get details of this article at this time:
   10.1101/2023.05.04.538701

10. Epistasis between mutator alleles contributes to germline mutation spectrum variability in laboratory mice

    This article has 3 authors:

    1. Thomas A Sasani
    2. Aaron R Quinlan
    3. Kelley Harris

    This article has been curated by 1 group:

    • Curated by eLife

      eLife assessment

      By developing a novel method for detecting genetic variants associated with germline mutation spectrum variation, this important study identifies a new "mutator" locus in a population of inbred mouse strains, although the causal gene(s) and allele(s) within this locus remain uncertain. The authors further demonstrate that this new mutator locus interacts epistatically with a previously identified mutator allele on C>A mutation rate, showcasing the complexity of the genetic basis underlying variation in mutation rate and spectrum. Evidence for major findings in this paper is convincing, and the new method has the potential to be applicable to a variety of experimental systems and natural populations.

    Reviewed by eLife