eLife reviews preprints in the life sciences and medicine.

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  1. Motor actions are spatially organized in motor and dorsal premotor cortex

    1. Nicholas G Chehade
    2. Omar A Gharbawie

    • Curated by eLife

      eLife assessment

      This paper measures the neural activity in reach-to-grasp and reach-only tasks using intrinsic optical imaging. The paper describes these in the relationship to the Intra-cortical micro stimulation maps of the same animals. The dataset is unique and potentially highly important. However, the claim of "clustered neural activity" is not tested against any quantifiable alternative hypothesis of non-clustered activity, and support for this idea is therefore currently incomplete.

    Reviewed by eLife

    4 evaluationsAppears in 1 listLatest version Latest activity

  2. Estimating the true stability of the prehydrolytic outward-facing state in an ABC protein

    1. Márton A Simon
    2. Iordan Iordanov
    3. Andras Szollosi
    4. László Csanády

    • Curated by eLife

      eLife assessment

      This study uncovers a unique feature of the nucleotide binding domain interface in human CFTR, offering valuable insights into the effects of different non-hydrolytic mutations on CFTR gating. While the evidence presented is solid, a more thorough examination of the non-hydrolytic mutants of zebrafish CFTR for comparison would strengthen the authors' claims. In the current form, more cautious interpretations of some of the data are needed. This study will be of interest to researchers in the fields of cystic fibrosis and proteins in the ATP Binding Cassette (ABC) transporter family.

    Reviewed by eLife

    4 evaluationsAppears in 2 listsLatest version Latest activity

  3. Vibrio cholerae’s ToxRS bile sensing system

    1. Nina Gubensäk
    2. Theo Sagmeister
    3. Christoph Buhlheller
    4. Bruno Di Geronimo
    5. Gabriel E Wagner
    6. Lukas Petrowitsch
    7. Melissa A Gräwert
    8. Markus Rotzinger
    9. Tamara M Ismael Berger
    10. Jan Schäfer
    11. Isabel Usón
    12. Joachim Reidl
    13. Pedro A Sánchez-Murcia
    14. Klaus Zangger
    15. Tea Pavkov-Keller

    • Curated by eLife

      eLife assessment

      This study provides important insights into the structural biology and molecular mechanism of the sensory proteins ToxR/S that are associated with survival and virulence of the cholera pathogen. The structural studies are solid and supported by a series of biophysical experiments revealing a split, periplasmic protein binding interface for bile acid. The results are of interest to both protein biochemistry and pharmacology, potentially opening new routes for intervention in cholera disease.

    Reviewed by eLife

    4 evaluationsAppears in 1 listLatest version Latest activity

  6. Myristoyl’s dual role in allosterically regulating and localizing Abl kinase

    1. Svenja de Buhr
    2. Frauke Gräter

    • Curated by eLife

      eLife assessment

      This is an important study of the mechanism of how binding of the fatty acid myristic acid (MYR) inhibits the activity of the kinase c-Abl, a critical regulator of many cellular processes. While the general aspects of this regulation are known from structure determination and biochemical studies, the exact molecular mechanism and the nature of the allosteric inhibition were not known. The authors use MD simulation to close this gap and provide a detailed mechanistic description of the inhibitory mechanism, although some of the evidence remains incomplete.

    Reviewed by eLife

    4 evaluationsAppears in 1 listLatest version Latest activity
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