eLife

Latest preprint reviews

1. Understanding disruptions in cancer care to reduce increased cancer burden

   This article has 8 authors:

   1. Kia L Davis
   2. Nicole Ackermann
   3. Lisa M Klesges
   4. Nora Leahy
   5. Callie Walsh-Bailey
   6. Sarah Humble
   7. Bettina Drake
   8. Vetta L Sanders Thompson

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     The study presents patterns of cancer care disruption in southern Illinois and eastern Missouri in the summer of 2020. Survey results show factors that impact cancer care during the COVID-19 pandemic, including group differences by race. The important findings provide solid evidence about variation in cancer care disruptions and opportunities to improve return to care.

   Reviewed by eLife

2. A hierarchical model for external electrical control of an insect, accounting for inter-individual variation of muscle force properties

   This article has 3 authors:

   1. Dai Owaki
   2. Volker Dürr
   3. Josef Schmitz

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This valuable work presents new results to characterize the relationship between electrical excitation and torque generation in stick insect joints. The evidence supporting this work is a series of torque-voltage measurements across individuals. The strength of evidence is solid in supporting the outcomes, but some details of the methodology, which could potentially shed light on the sources of this variation, are missing.

   Reviewed by eLife

3. ONC201/TIC10 enhances durability of mTOR inhibitor everolimus in metastatic ER+ breast cancer

   This article has 7 authors:

   1. Elena Farmaki
   2. Aritro Nath
   3. Rena Emond
   4. Kimya L Karimi
   5. Vince K Grolmusz
   6. Patrick A Cosgrove
   7. Andrea H Bild

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study presents a valuable finding on the combination treatment of ONC201/TIC10 with everolimus for metastatic ER+ breast cancer. The evidence supporting the claims of the authors is solid. The work will be of interest to medical biologists working on breast cancer.

   Reviewed by eLife

4. Rodent ultrasonic vocal interaction resolved with millimeter precision using hybrid beamforming

   This article has 3 authors:

   1. Max L Sterling
   2. Ruben Teunisse
   3. Bernhard Englitz

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study demonstrates an important method that drastically improves the precision of ultrasound localization in interacting mice. The authors present convincing evidence of the usefulness of the method for quantifying vocal behavior in various situations and demonstrate an interesting vocal dominance phenomenon between males. This tool will be of great interest to all scientists interested in vocal behavior in small animals.

   Reviewed by eLife

5. Discovery and characterization of a specific inhibitor of serine-threonine kinase cyclin-dependent kinase-like 5 (CDKL5) demonstrates role in hippocampal CA1 physiology

   This article has 19 authors:

   1. Anna Castano
   2. Margaux Silvestre
   3. Carrow I Wells
   4. Jennifer L Sanderson
   5. Carla A Ferrer
   6. Han Wee Ong
   7. Yi Lang
   8. William Richardson
   9. Josie A Silvaroli
   10. Frances M Bashore
   11. Jeffery L Smith
   12. Isabelle M Genereux
   13. Kelvin Dempster
   14. David H Drewry
   15. Navlot S Pabla
   16. Alex N Bullock
   17. Tim A Benke
   18. Sila K Ultanir
   19. Alison D Axtman

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important study reports selective CDKL5 inhibitors that may be of high interest to investigate the role of this kinase in disease (particularly, in CDKL5 deficiency disorder) and to address unsolved issues of inconsistency in the phenotypic characterization of CDKL5-deficient knockout mice. The evidence supporting the conclusions is convincing, with rigorous biochemical, in vitro and ex vivo assays. The work will be of interest to cell and medical biologists and epileptologists working in the fields of epilepsy and neural excitation.

   Reviewed by eLife

6. Modeling resource allocation strategies for insecticide-treated bed nets to achieve malaria eradication

   This article has 8 authors:

   1. Nora Schmit
   2. Hillary M Topazian
   3. Matteo Pianella
   4. Giovanni D Charles
   5. Peter Winskill
   6. Michael T White
   7. Katharina Hauck
   8. Azra C Ghani

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study presents a valuable finding on the optimal prioritization in different malaria transmission settings for the distribution of insecticide-treated nets to reduce the malaria burden. The evidence supporting the claims of the authors is solid. The work will be of interest from a global funder perspective, though somewhat less relevant for individual countries.

   Reviewed by eLife

7. History information emerges in the cortex during learning

   This article has 5 authors:

   1. Odeya Marmor
   2. Yael Pollak
   3. Chen Doron
   4. Fritjof Helmchen
   5. Ariel Gilad

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This is important work analyzing the trial-by-trial progression of learning, and how the outcome of one trial influences cortex-wide neural responses on the next trial. However, the evidence for the central claims is incomplete because the potential confounds of slow hemodynamic effects and behavioral changes induced by the previous trial were not adequately addressed.

   Reviewed by eLife

8. A human mitofusin 2 mutation can cause mitophagic cardiomyopathy

   This article has 13 authors:

   1. Antonietta Franco
   2. Jiajia Li
   3. Daniel P Kelly
   4. Ray E Hershberger
   5. Ali J Marian
   6. Renate M Lewis
   7. Moshi Song
   8. Xiawei Dang
   9. Alina D Schmidt
   10. Mary E Mathyer
   11. John R Edwards
   12. Cristina de Guzman Strong
   13. Gerald W Dorn

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     In this paper, the authors demonstrate an interesting link between mitofusin function (MFN2) and PARKIN recruitment and mitophagy, underlying cardiomyopathy. This is a valuable finding with broad implications for understanding the mitochondrial biology as well as mechanisms involved in heart pathologies. However, the analyses are incomplete and the main conclusions are only partially supported and need to be further evidenced.

   Reviewed by eLife

9. Circulating small extracellular vesicle RNA profiling for the detection of T1a stage colorectal cancer and precancerous advanced adenoma

   This article has 10 authors:

   1. Li Min
   2. Fanqin Bu
   3. Jingxin Meng
   4. Xiang Liu
   5. Qingdong Guo
   6. Libo Zhao
   7. Zhi Li
   8. Xiangji Li
   9. Shengtao Zhu
   10. Shutian Zhang

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study presents a useful description of RNA in extracellular vesicles (EV-RNAs) and highlights the potential to develop biomarkers for the early detection of colorectal cancer (CRC) and precancerous adenoma (AA). The data were analysed using overall solid methodology and would benefit from further validation of predicted lncRNAs and biomarker validation at each stage of CRC/AA to evaluate the potential application to early detection of CRC and AA.

   Reviewed by eLife

10. The target of rapamycin signaling pathway regulates vegetative development, aflatoxin biosynthesis, and pathogenicity in Aspergillus flavus

    This article has 5 authors:

    1. Guoqi Li
    2. Xiaohong Cao
    3. Elisabeth Tumukunde
    4. Qianhua Zeng
    5. Shihua Wang

    This article has been curated by 1 group:

    • Curated by eLife

      eLife assessment

      This manuscript provides important information about the influence of TOR signaling pathway on development and aflatoxin production in the plant and human fungal pathogen Aspergillus flavus. Compared to an earlier version, the authors have addressed most of the concerns of the reviewers, including the convincing demonstration of the essential TOR pathway in this fungus by constructing a xylose promoter mutant strain.

    Reviewed by eLife