Latest preprint reviews

  1. Novel discoveries and enhanced genomic prediction from modelling genetic risk of cancer age-at-onset

    This article has 7 authors:
    1. Ekaterina S. Maksimova
    2. Sven E. Ojavee
    3. Kristi Läll
    4. Marie C. Sadler
    5. Reedik Mägi
    6. Zoltan Kutalik
    7. Matthew R. Robinson
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This manuscript is a useful contribution to the field of complex trait genomics. The study does have some real strengths, such as focusing on cancer age-of-onset, developing methods for this unusual trait and using two cohorts. However, the significance of findings is difficult to evaluate without further comparisons and validations, leaving the work in its current form incomplete.

    Reviewed by eLife

    This article has 3 evaluationsAppears in 1 listLatest version Latest activity
  2. Post-EMT: Cadherin-11 mediates cancer hijacking fibroblasts

    This article has 25 authors:
    1. Weirong Kang
    2. Yibo Fan
    3. Yinxiao Du
    4. Elina A. Tonkova
    5. Yi-Hsin Hsu
    6. Kel Vin Tan
    7. Stephanie Alexander
    8. Bin Sheng Wong
    9. Haocheng Yang
    10. Jingyuan Luo
    11. Kuo Yao
    12. Jiayao Yang
    13. Xin Hu
    14. Tingting Liu
    15. Yu Gan
    16. Jian Zhang
    17. Jean J. Zhao
    18. Konstantinos Konstantopoulos
    19. Peter Friedl
    20. Pek Lan Khong
    21. Aiping Lu
    22. Mien-Chie Hung
    23. Michael B. Brenner
    24. Jeffrey E. Segall
    25. Zhizhan Gu
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This paper presents a series of experiments investigating the role of cadherin-11 mediated interactions between cancer cells and fibroblasts in metastasis using updated 3D cell co-invasion assays. The primarily descriptive data are a valuable contribution to our understanding of the nature of cross cell-type interactions in metastasis, but are incomplete with respect to the far-reaching conclusions about the central role cadherin-11, especially given the complex nature of the phenotype and the need to better contextualize these observations in a complete picture of metastasis.

    Reviewed by eLife

    This article has 3 evaluationsAppears in 1 listLatest version Latest activity
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