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  1. Efficient estimation for large-scale linkage disequilibrium patterns of the human genome

    This article has 6 authors:
    1. Xin Huang
    2. Tian-Neng Zhu
    3. Ying-Chao Liu
    4. Guo-An Qi
    5. Jian-Nan Zhang
    6. Guo-Bo Chen
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This study presents a valuable new approach for efficient computation of statistics on correlations between genetic variants (linkage disequilibrium, or LD), which the authors apply to quantify the extent of LD across chromosomes. The method appears solid, although the presentation of equations needs clarification and improvement. The authors document that cross-chromosome LD can be substantial, which has implications for geneticists who are interested in population structure and its impact on genetic association studies.

    Reviewed by eLife

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