eLife

Latest preprint reviews

1. The Anti-Inflammatory Role of GPNMB in Post-Traumatic Osteoarthritis

   This article has 9 authors:

   1. Asaad A Al-Adlaan
   2. Bryson Cook
   3. Nazar J Hussein
   4. Fatima A Jaber
   5. Trinity Kronk
   6. Ernesto Solorzano Z
   7. Salvatore Frangiamore
   8. Hope C Ball
   9. Fayez F Safadi

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study demonstrates the cartilage-protective effects of osteoactivin in inflammatory experimental models. The work offers valuable insights advancing current knowledge regarding regulation of joint inflammation and tissue degeneration. The evidence provided is compelling and suggests that osteoactivin may serve as a promising therapeutic target for inflammatory joint diseases.

   Reviewed by eLife

2. Atypical collective oscillatory activity in cardiac tissue uncovered by optogenetics

   This article has 7 authors:

   1. Alexander S Teplenin
   2. Nina N Kudryashova
   3. Rupamanjari Majumder
   4. Antoine AF de Vries
   5. Alexander V Panfilov
   6. Daniël A Pijnappels
   7. Tim De Coster

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important work provides mechanistic insights into the development of cardiac arrhythmia and establishes a new experimental use case for optogenetics in studying cardiac electrophysiology. The agreement between computational models and experimental observations provides a convincing level of evidence that wave train-induced pacemaker activity can originate in continuously depolarized tissue, with the limitation that there may be differences between depolarization arising from constant optogenetic stimulation, as opposed to pathophysiological tissue depolarization. Future experiments in vivo and in other tissue preparations would extend the generality of these findings.

   Reviewed by eLife

3. Non-equilibrium strategies enabling ligand specificity by signaling receptors

   This article has 4 authors:

   1. Andrew Goetz
   2. Jeremy Barrios
   3. Ralitsa Radostinova Madsen
   4. Purushottam D Dixit

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study presents a valuable finding about how receptor-ligand binding pathways with multi-site phosphorylation can show non-monotonic responses to increasing ligand affinity and to kinase activity. The authors provide compelling evidence through a simple ordinary differential equation model of such signaling networks with the key new ingredient of ligand-induced receptor degradation. The work will be of interest to physicists and biologists working on signal transduction and biological information processing.

   Reviewed by eLife

4. Estimating probabilities of malaria importation in southern Mozambique through P. falciparum genomics and mobility patterns

   This article has 33 authors:

   1. Arnau Pujol
   2. Arlindo Chidimatembue
   3. Clemente da Silva
   4. Simone Boene
   5. Henriques Mbeve
   6. Pau Cisteró
   7. Carla García-Fernández
   8. Arnau Vañó-Boira
   9. Dário Tembisse
   10. José Inácio
   11. Glória Matambisso
   12. Fabião Luis
   13. Nelo Ndimande
   14. Humberto Munguambe
   15. Lidia Nhamussua
   16. Wilson Simone
   17. Andrés Aranda-Díaz
   18. Manuel García-Ulloa
   19. Neide Canana
   20. Maria Tusell
   21. Júlia Montaña
   22. Laura Fuente-Soro
   23. Khalid Ussene Bapu
   24. Maxwell Murphy
   25. Bernardete Rafael
   26. Eduard Rovira-Vallbona
   27. Caterina Guinovart
   28. Bryan Greenhouse
   29. Sonia Maria Enosse
   30. Francisco Saúte
   31. Pedro Aide
   32. Baltazar Candrinho
   33. Alfredo Mayor

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     The authors present an important approach to identify imported P. falciparum malaria cases, combining genetic and epidemiological/travel data. This tool has the potential to be expanded to other contexts. The data was analyzed using convincing methods, including a novel statistical model. This study may be of interest to researchers in public health and infectious diseases beyond malaria.

   Reviewed by eLife

5. Working memory shapes neural geometry in human EEG over learning

   This article has 7 authors:

   1. Michał J Wójcik
   2. Amy Li
   3. Dante Wasmuht
   4. Jake P Stroud
   5. Mark G Stokes
   6. Nicholas E Myers
   7. Laurence T Hunt

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     The findings are valuable, given that they highlight the flexible and future-oriented nature of working memory. However, the evidence for the claims about context/color generalization, behavioural relevance of context decoding, dimensionality reduction, neural geometry, the XOR representation, and the specific contribution of working memory is incomplete. The work could be reframed in terms of prospective remapping.

   Reviewed by eLife

6. The influence of nucleus accumbens shell D1 and D2 neurons on outcome-specific Pavlovian instrumental transfer

   This article has 6 authors:

   1. Octavia Soegyono
   2. Elise Pepin
   3. Beatrice K Leung
   4. Billy Chieng
   5. Bernard W Balleine
   6. Vincent Laurent

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study provides novel and convincing evidence that both dopamine D1 and D2 expressing neurons in the nucleus accumbens shell are crucial for the expression of cue-guided action selection, a core component of decision-making. The research is systematic and rigorous in using optogenetic inhibition of either D1- or D2-expressing medium spiny neurons in the NAc shell to reveal attenuation of sensory-specific Pavlovian-Instrumental transfer, while largely sparing value-based decision on an instrumental task. The important findings in this report build on prior research and resolve some conflicts in the literature regarding decision-making.

   Reviewed by eLife

7. Hypothalamic deiodinase type-3 establishes the period of circannual interval timing in mammals

   This article has 9 authors:

   1. Calum Stewart
   2. T Adam Liddle
   3. Elisabetta Tolla
   4. Jo Edward Lewis
   5. Christopher Marshall
   6. Neil P Evans
   7. Peter J Morgan
   8. Fran JP Ebling
   9. Tyler J Stevenson

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study provides important findings on the understanding of circannual timing in mammals, for which iodothyronine deiodinases (DIOs) have been suggested to be of critical importance, yet functional genetic evidence has been missing. The authors convincingly implicate dio3, the major inactivator of the biologically active thyroid hormone T3, in circannual timing in Djungarian hamsters, using a combination of correlative and gene knock-out experiments; thus this provides key insights into the evolution and function of animal annual timing mechanisms.

   Reviewed by eLife

8. Paraventricular Thalamus Hyperactivity Mediates Stress-Induced Sensitization of Unlearned Fear but Not Stress-Enhanced Fear Learning (SEFL)

   This article has 5 authors:

   1. Kenji J Nishimura
   2. Denisse Paredes
   3. Nathaniel A Nocera
   4. Dhruv Aggarwal
   5. Michael R Drew

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     These findings are among some of the first to identify a behavioral and neurobiological substrate that disentangles nonassociative from associative fear responses following stress, providing a fundamental push forward in the field. The evidence supporting this is convincing and uses a variety of conceptual and technological approaches. This investigation will be of interest to neuroscientists and behaviourists broadly, as well as clinicians for its relevance to post-traumatic stress disorder.

   Reviewed by eLife

9. Economic and Social Modulations of Innate Decision-Making in Mice Exposed to Visual Threats

   This article has 6 authors:

   1. Zhe Li
   2. Jiahui Wang
   3. Yidan Sun
   4. Jialin Li
   5. Ling-yun Li
   6. Ya-tang Li

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     The authors show that innate defensive behavior in mice is shaped by threat intensity, reward value, and social hierarchy, highlighting how value and social context influence instinctive decisions. The authors provide useful behavioural findings supported by strong data, yet the evidence is incomplete due to ambiguities about methodology and the computational model that remains largely descriptive.

   Reviewed by eLife

10. A theory and recipe to construct general and biologically plausible integrating continuous attractor neural networks

    This article has 3 authors:

    1. Federico Claudi
    2. Sarthak Chandra
    3. Ila R Fiete

    This article has been curated by 1 group:

    • Curated by eLife

      eLife Assessment

      This valuable study presents a theoretical framework for building continuous attractor networks that integrate with a wide range of topologies, which are of increasing relevance to neuroscientists. While the work offers solid evidence for most claims, the evidence supporting biological plausibility and key claims - such as the existence of a continuum of stable states and robustness across geometries - is currently incomplete and would benefit from further analysis or discussion. The study will be of interest to computational and systems neuroscientists working on neural dynamics and network models of cognition.

    Reviewed by eLife