eLife

Latest preprint reviews

1. Tolerance to Lung Infection in TWIK2 K+ Efflux Mediated Macrophage Trained Immunity

   This article has 6 authors:

   1. Josh Thompson
   2. Yufan Li
   3. Yuanling Song
   4. Ki-Wook Kim
   5. Asrar B Malik
   6. Jingsong Xu

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study presents valuable data suggesting that ATP-induced modulation of alveolar macrophage (AM) functions is associated with NLRP3 inflammasome activation and enhanced phagocytic capacity. While the in vivo and in vitro data reveal an interesting phenotype, the evidence provided is incomplete and does not fully support the paper's conclusions. Additional investigations would be of value in complementing the data and strengthening the interpretation of the results. This study should be of interest to immunologists and the mucosal immunity community.

   Reviewed by eLife

2. Quantitative RNA pseudouridine landscape reveals dynamic modification patterns and evolutionary conservation across bacterial species

   This article has 10 authors:

   1. Letong Xu
   2. Shenghai Shen
   3. Yizhou Zhang
   4. Zhihao Guo
   5. Beifang Lu
   6. Jiadai Huang
   7. Runsheng Li
   8. Yitong Shen
   9. Li-Sheng Zhang
   10. Xin Deng

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study illustrates a valuable application of BID-seq to bacterial RNA, allowing transcriptome-wide mapping of pseudouridine modifications across various bacterial species. The evidence presented includes a mix of solid and incomplete data and analyses, and would benefit from more rigorous approaches. The work will interest a specialized audience involved in RNA biology.

   Reviewed by eLife

3. Starvation of the bacteria Vibrio atlanticus promotes lightning group-attacks on the dinoflagellate Alexandrium pacificum

   This article has 13 authors:

   1. Jean Luc Rolland
   2. Estelle Masseret
   3. Mohamed Laabir
   4. Guillaume Tetreau
   5. Benjamin Gourbal
   6. Anne Thebault
   7. Eric Abadie
   8. Alice Rodrigues-Stien
   9. Carole Veckerlé
   10. Elodie Servanne-Meunier
   11. Delphine Destoumieux-Garzón
   12. Arnaud Lagorce
   13. Raphaël Lami

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study convincingly shows that Vibrio bacteria act as predators of ecologically significant algae that contribute to harmful blooms in the lab, as well as in their natural habitat. While the data strongly suggest that starvation may induce predation, further work is needed to fully establish this link. Similarly, the evidence for a social component in the predation process remains incomplete. This study will be very impactful to those interested in the diversity of microbial predator-prey interactions and controlling toxic algal bloom, but the paper could be strengthened by more clearly showing the degree of replication, by better defining the terms used to describe the observed behaviour, and by providing better support for starvation and collective behaviour.

   Reviewed by eLife

4. Realistic coupling enables flexible macroscopic traveling waves in the mouse cortex

   This article has 4 authors:

   1. Guanhua Sun
   2. James Hazelden
   3. Ruby Kim
   4. Daniel B Forger

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This valuable work presents a novel computational framework for modeling macroscopic traveling waves in the mouse cortex by integrating open-source connectomic and transcriptomic data into a spiking network model. This approach allows the computational model to assign excitatory/inhibitory connections based on neurotransmitter profiles and extends simulations to the 3D domain. The authors present results that demonstrate how spatiotemporal dynamics such as slow oscillations (0.5-4 Hz) emerge and self-organize at the whole-brain scale. This study provides convincing initial insights into the structural basis of traveling waves at the whole-brain scale in the mouse.

   Reviewed by eLife

5. Neural Connectome of the Ctenophore Statocyst

   This article has 5 authors:

   1. Kei Jokura
   2. Sanja Jasek
   3. Lara Niederhaus
   4. Pawel Burkhardt
   5. Gáspár Jékely

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This fundamental work significantly advances our understanding of gravity sensing and orientation behavior in the ctenophore, an animal of major importance in understanding the evolution of nervous systems. Through comprehensive reconstruction with volumetric electron microscopy, and time-lapse imaging of cilia motion, the authors provide compelling evidence that the aboral nerve net coordinates the activity of balancer cilia. The resemblance to the ciliomotor circuit in marine annelids provides a fascinating example of how neural circuits may convergently evolve to solve common sensorimotor challenges.

   Reviewed by eLife

6. Adrenomedullin restores the human cortical interneurons migration defects induced by hypoxia

   This article has 14 authors:

   1. Alyssa Puno
   2. Wojciech P Michno
   3. Li Li
   4. Amanda Everitt
   5. Kate McCluskey
   6. Saw Htun
   7. Dhriti Nagar
   8. Jong Bin Choi
   9. Yuqin Dai
   10. Seyeon Park
   11. Emily Gurwitz
   12. A Jeremy Willsey
   13. Fikri Birey
   14. Anca M Pasca

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     In this manuscript, the authors investigate the migration of human cortical interneurons under hypoxic conditions using forebrain assembloids and developing human brain tissue, and probe the underlying mechanisms. The study provides the first direct evidence that hypoxia delays interneuron migration and identifies adrenomedullin (ADM) as a potential therapeutic intervention. The findings are important, and the conclusions are convincingly supported by experimental evidence.

   Reviewed by eLife

7. Sp Transcription Factors Establish the Signaling Environment in the Neuromesodermal Progenitor Niche During Axial Elongation

   This article has 11 authors:

   1. Ravindra B Chalamalasetty
   2. Haley Tran
   3. Ryan Kelly
   4. Samuel Kuo
   5. Mark W Kennedy
   6. Moonsup Lee
   7. Sara Thomas
   8. Nikolaos Mandalos
   9. Vishal Koparde
   10. Francisco Pereira Lobo
   11. Terry P Yamaguchi

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This fundamental work advances our understanding of how SP5 and SP8 promote neuromesodermal competent progenitors in murine embryos. Generally the evidence is compelling, with strong developmental genetics, transcriptomic, and genomic transcription binding surveys contributing to the strength of the data. Some of the language could be softened to avoid overinterpretation of the data, and figures and diagrams could be improved.

   Reviewed by eLife

8. Cortical projection neurons with distinct axonal connectivity employ ribosomal complexes with distinct protein compositions

   This article has 4 authors:

   1. Tien Phuoc Tran
   2. Bogdan Budnik
   3. John E Froberg
   4. Jeffrey D Macklis

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study presents a valuable and rigorous molecular resource, offering subtype-specific insight into the composition of ribosome-associated protein complexes in the developing cerebral cortex. The evidence is compelling in terms of data quality and is strongly supported by the results, given the rigorous technical execution. However, the findings remain primarily descriptive, as the study lacks functional validation to support mechanistic conclusions.

   Reviewed by eLife

9. Morphology and ultrastructure of pharyngeal sense organs of Drosophila larvae

   This article has 4 authors:

   1. Vincent Richter
   2. Tilman Triphan
   3. Albert Cardona
   4. Andreas S Thum

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     In this fundamental manuscript, Richter et al. present a thorough anatomical characterization of the Drosophila melanogaster larval pharyngeal sensory system, which is involved in taste-guided behaviors. This study fills a major gap in the larval sensory map, providing a compelling neuroanatomical foundation for future investigations into sensory circuits and behavior. The data presented here are of exceptional quality and will be of interest to the Drosophila neurobiology community.

   Reviewed by eLife

10. Human neurocomputational mechanisms of guilt-driven and shame-driven altruistic behavior

    This article has 7 authors:

    1. Ruida Zhu
    2. Huanqing Wang
    3. Chunliang Feng
    4. Linyuan Yin
    5. Ran Zhang
    6. Yi Zeng
    7. Chao Liu

    This article has been curated by 1 group:

    • Curated by eLife

      eLife Assessment

      This is an important study on how dissociable emotions of shame and guilt emerge from cognitive processes and guide behavioral responses. The task is well designed and yields compelling behavioral, computational, and neural evidence elucidating the cognitive link between emotions and compensatory decisions. The work has broad theoretical and practical implications across a range of disciplines concerned with human behavior, including psychology, neuroscience, economics, public policy, and psychiatry.

    Reviewed by eLife