eLife

Latest preprint reviews

1. The genomic landscape of transposable elements in yeast hybrids is shaped by structural variation and genotype-specific modulation of transposition rate

   This article has 4 authors:

   1. Mathieu Hénault
   2. Souhir Marsit
   3. Guillaume Charron
   4. Christian R Landry

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This valuable study advances our understanding of the forces that shape the genomic landscape of transposable elements. By exploiting both long-read sequencing of mutation accumulation lines and in vivo transposition assays, the authors offer compelling evidence that structural variation rather than transposition largely shapes transposable element copy number evolution in budding yeast. The work will be of interest to the transposable element and genome evolution communities.

   Reviewed by eLife

2. Chromosome-specific maturation of the epigenome in the Drosophila male germline

   This article has 3 authors:

   1. James T Anderson
   2. Steven Henikoff
   3. Kami Ahmad

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     Using a variety of methods including mutant analyses, the authors study chromatin structure during spermatogenesis in Drosophila and transcriptional profiling in single cells/nuclei. This description of the dramatic changes in chromatin structure during spermatogenesis leads to some new observations, with convincing evidence, and it is useful for the field.

   Reviewed by eLife

3. Evolution towards simplicity in bacterial small heat shock protein system

   This article has 7 authors:

   1. Piotr Karaś
   2. Klaudia Kochanowicz
   3. Marcin Pitek
   4. Przemyslaw Domanski
   5. Igor Obuchowski
   6. Barlomiej Tomiczek
   7. Krzysztof Liberek

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This valuable study advances our understanding of the evolution of protein complexes and their functions. Through convincing experimental and computational methodologies, the authors show that the specialization of protein function following gene duplication can be reversible. The work will be of interest to investigators working in biochemical evolution and those working on heat shock proteins.

   Reviewed by eLife

4. Explicit ion modeling predicts physicochemical interactions for chromatin organization

   This article has 2 authors:

   1. Xingcheng Lin
   2. Bin Zhang

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     The authors have developed a compelling coarse-grained simulation approach for nucleosome-nucleosome interactions within a chromatin array. The data presented are solid and provide new insights that allow for predictions of how chromatin interactions might occur in vivo. The tools presented herein will be valuable for the chromosome biology field.

   Reviewed by eLife

5. Leucine alleviates cytokine storm syndrome by regulating macrophage polarization via the mTORC1/LXRα signaling pathway

   This article has 12 authors:

   1. Hui Yan
   2. Yao Liu
   3. Xipeng Li
   4. Bing Yu
   5. Jun He
   6. Xiangbing Mao
   7. Jie Yu
   8. Zhiqing Huang
   9. Yuheng Luo
   10. Junqiu Luo
   11. Aimin Wu
   12. Daiwen Chen

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     The study has added value to what we have already known in the potential pharmacological immunomodulatory therapies in LPS-induced sepsis, and especially the use of oral leucine might be of great interest to the readers engaged in this field. We believe this study is important and provides solid evidence on the potential use of leucine in sepsis.

   Reviewed by eLife

6. Neural correlates and reinstatement of recent and remote memory in children and young adults

   This article has 7 authors:

   1. Iryna Schommartz
   2. Philip F Lembcke
   3. Javier Ortiz-Tudela
   4. Martin Bauer
   5. Angela M Kaindl
   6. Claudia Buss
   7. Yee Lee Shing

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This paper provides potentially valuable insight into why memory consolidation may differ between children (5-7 years of age) and adults. The work hints at developmental differences in neural engagement during the retrieval of recent and remote memories. However, there are several major concerns with the analyses not alleviated by included controls, and as such the evidence supporting the authors' main claims remains incomplete.

   Reviewed by eLife

7. Endosomal dysfunction contributes to cerebellar deficits in spinocerebellar ataxia type 6

   This article has 6 authors:

   1. Anna A Cook
   2. Tsz Chui Sophia Leung
   3. Max Rice
   4. Maya Nachman
   5. Élyse Zadigue-Dube
   6. Alanna Jean Watt

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This manuscript provides valuable insights to the underlying mechanism for Spinocerebellar ataxia 6 (SCA6) due to defective endolysosomal trafficking of BDNF and its receptor TrkB. The findings are compelling and significant in understanding the underlying pathology of SCA6. The authors have acknowledged the experimental weaknesses and recognize there may be multiple mechanisms to explain the findings.

   Reviewed by eLife

8. Serotonergic and dopaminergic neurons in the dorsal raphe are differentially altered in a mouse model for parkinsonism

   This article has 6 authors:

   1. Laura Boi
   2. Yvonne Johansson
   3. Raffaella Tonini
   4. Rosario Moratalla
   5. Gilberto Fisone
   6. Gilad Silberberg

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important work provides convincing data on neuronal heterogeneity in the dorsal raphe nucleus (DRN), focusing on their electrophysiological properties, morphology, and susceptibility to the neurodegeneration of noradrenaline and dopamine systems in the Parkinsonian state. These findings suggest a significant interplay between catecholaminergic systems in healthy and parkinsonian conditions, as well as neuronal structure and function. Such findings provide a strong foundation for basic scientists as well as pre-clinical researchers interested in the role of dorsal raphe neurons in Parkinson's disease.

   Reviewed by eLife

9. Regulation of hippocampal mossy fiber-CA3 synapse function by a Bcl11b/C1ql2/Nrxn3(25b+) pathway

   This article has 11 authors:

   1. Artemis Koumoundourou
   2. Märt Rannap
   3. Elodie De Bruyckere
   4. Sigrun Nestel
   5. Carsten Reissner
   6. Alexei V Egorov
   7. Pengtao Liu
   8. Markus Missler
   9. Bernd Heimrich
   10. Andreas Draguhn
   11. Stefan Britsch

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     The authors identify a new role for C1ql2 at mossy fiber synapses in the hippocampus and convincingly find that C1ql2, whose expression is controlled by Bcl11b, controls the recruitment of synaptic vesicles to active zones and is necessary for synaptic plasticity. These important results build upon prior discoveries of how Bcl11b, a disease-relevant molecule, contributes to our understanding of mossy-fiber synaptic development.

   Reviewed by eLife

10. Complexes of vertebrate TMC1/2 and CIB2/3 proteins form hair-cell mechanotransduction cation channels

    This article has 17 authors:

    1. Arnaud PJ Giese
    2. Wei-Hsiang Weng
    3. Katie S Kindt
    4. Hui Ho Vanessa Chang
    5. Jonathan S Montgomery
    6. Evan M Ratzan
    7. Alisha J Beirl
    8. Roberto Aponte Rivera
    9. Jeffrey M Lotthammer
    10. Sanket Walujkar
    11. Mark P Foster
    12. Omid A Zobeiri
    13. Jeffrey R Holt
    14. Saima Riazuddin
    15. Kathleen E Cullen
    16. Marcos Sotomayor
    17. Zubair M Ahmed

    This article has been curated by 1 group:

    • Curated by eLife

      eLife Assessment

      This paper, on the role of calcium and integrin-binding protein 2 and 3 in the hair-cell in the mechano-electrical transduction (MET) apparatus, is a mix of confirmatory studies with new and potentially important data. Some parts, such as zebrafish studies, the modelling and simulations, are regarded as necessary and convincing. Other parts of the paper do not have the same novelty. Both Liang et al. (2021) and Wang et al. (2023) had previously demonstrated a role for CIB2/CIB3 in auditory and vestibular cells in mice. Moreover, there are also data in Riazuddin et al. (2012) paper that demonstrates the importance of CIB2 in zebrafish and Drosophila. Breaking the manuscript up to focus on specific aspects of the problem might alleviate the limitations of this multi-faceted study.

    Reviewed by eLife