eLife

Latest preprint reviews

1. Notch signaling and Bsh homeodomain activity are integrated to diversify Drosophila lamina neuron types

   This article has 4 authors:

   1. Chundi Xu
   2. Tyler B Ramos
   3. Owen J Marshall
   4. Chris Q Doe

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This paper explores how Notch activity acts together with homeodomain transcription Bsh factors to establish distinct cell fates (L4 vs L5) in the visual system of Drosophila. The findings are important and have theoretical or practical implications beyond a single subfield. The methods, data, and analyses are compelling and support the claims with only minor weaknesses.

   Reviewed by eLife

2. A novel image segmentation method based on spatial autocorrelation identifies A-type potassium channel clusters in the thalamus

   This article has 6 authors:

   1. Csaba Dávid
   2. Kristóf Giber
   3. Katalin Kerti-Szigeti
   4. Mihály Köllő
   5. Zoltan Nusser
   6. Laszlo Acsady

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     The manuscript introduces an important and innovative non-AI computational method for segmenting noisy grayscale images, with a particular focus on identifying immunostained potassium ion channel clusters. This method significantly enhances accuracy over basic threshold-based techniques while remaining user-friendly and accessible, even for researchers with limited computational backgrounds. The evidence supporting the method's efficacy is convincing. Its practical application and ease of use make it a tool that will benefit a wide range of laboratories.

   Reviewed by eLife

3. Touch receptor end-organ innervation and function require sensory neuron expression of the transcription factor Meis2

   This article has 7 authors:

   1. Simon Desiderio
   2. Frederick Schwaller
   3. Kevin Tartour
   4. Kiran Padmanabhan
   5. Gary R Lewin
   6. Patrick Carroll
   7. Frederic Marmigere

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This fundamental study identifies the homeodomain transcription factor Meis2 as a transcriptional regulator of maturation and end-organ innervation of low-threshold mechanoreceptors (LTMRs) in the dorsal root ganglia (DRG) of mice. The authors use histology, behavioral tests, RNA-sequencing, and electrophysiological recordings to provide evidence that conditional deletion of Meis2 in postmitotic DRG neurons causes gene expression changes together with targeting errors and altered sensory neuron responses, ultimately resulting in reduced sensitivity to light touch in mutant animals. The data presented are convincing, the discussion comprehensive, and the conclusions drawn justified.

   Reviewed by eLife

4. Homeodomain proteins hierarchically specify neuronal diversity and synaptic connectivity

   This article has 5 authors:

   1. Chundi Xu
   2. Tyler B Ramos
   3. Edward M Rogers
   4. Michael B Reiser
   5. Chris Q Doe

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This paper, offering insights into the mechanisms of neuronal cell type diversification, provides important findings that have theoretical or practical implications beyond a single subfield. The data are compelling and provide evidence that features methods, data and analyses that are more rigorous than the current state-of-the-art.

   Reviewed by eLife

5. Tmem263 deletion disrupts the GH/IGF-1 axis and causes dwarfism and impairs skeletal acquisition

   This article has 5 authors:

   1. Dylan C Sarver
   2. Jean Garcia-Diaz
   3. Muzna Saqib
   4. Ryan C Riddle
   5. G William Wong

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study discloses important physiological function for TMEM63 in regulating postnatal growth in mice. The data supporting the impaired body growth and skeletal phenotype as well as disrupted growth hormone/insulin-like growth factor-I (GH/IGF-I) signaling in TMEM63 knockout mice are compelling. However, to establish that alteration of hepatic GH/IGF-I signaling is the cause for observed growth and skeletal phenotype in TMEM63 knockout mice would need additional work.

   Reviewed by eLife

6. Overcoming the nutritional immunity by engineering iron-scavenging bacteria for cancer therapy

   This article has 8 authors:

   1. Sin-Wei Huang
   2. See-Khai Lim
   3. Yao-An Yu
   4. Yi-Chung Pan
   5. Wan-Ju Lien
   6. Chung-Yuan Mou
   7. Che-Ming Jack Hu
   8. Kurt Yun Mou

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This valuable study combines proteomics and a mouse model to reveal the importance of iron uptake in bacterial therapy for cancer. The evidence presented is convincing. Notably, the authors showed upregulation of iron uptake of bacteria significantly inhibits tumor growth in vivo. This paper will be of interest to a broad audience including researchers in cancer biology, cell biology, and microbiology.

   Reviewed by eLife

7. Pulsed ultrasound promotes secretion of anti-inflammatory extracellular vesicles from skeletal myotubes via elevation of intracellular calcium level

   This article has 10 authors:

   1. Atomu Yamaguchi
   2. Noriaki Maeshige
   3. Hikari Noguchi
   4. Jiawei Yan
   5. Xiaoqi Ma
   6. Mikiko Uemura
   7. Dongming Su
   8. Hiroyo Kondo
   9. Kristopher Sarosiek
   10. Hidemi Fujino

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study illuminates the effects of ultrasound-induced extracellular vesicle interactions with macrophages. It provides solid data offering insights that will be potentially useful in exploring therapeutic approaches to inflammation modulation, by suggesting that ultrasound-treated myotube vesicles can suppress macrophage inflammatory responses.

   Reviewed by eLife

8. The ORP9-ORP11 dimer promotes sphingomyelin synthesis

   This article has 8 authors:

   1. Birol Cabukusta
   2. Shalom Borst Pauwels
   3. Jimmy JLL Akkermans
   4. Niek Blomberg
   5. Aat A Mulder
   6. Roman I Koning
   7. Martin Giera
   8. Jacques Neefjes

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This valuable manuscript systematically addresses the role of intracellular lipid transfer proteins on cellular lipid levels. It provides convincing evidence on the role of ORP9 and ORP11 in sphingolipid metabolism at the Golgi complex. This article will be of broad interest to cell biologists interested in lipid metabolism and membrane biology.

   Reviewed by eLife

9. Nifuroxazide suppresses PD-L1 expression and enhances the efficacy of radiotherapy in hepatocellular carcinoma

   This article has 20 authors:

   1. Tiesuo Zhao
   2. Pengkun Wei
   3. Congli Zhang
   4. Shijie Zhou
   5. Lirui Liang
   6. Shuoshuo Guo
   7. Zhinan Yin
   8. Sichang Cheng
   9. Zerui Gan
   10. Yuanling Xia
   11. Yongxi Zhang
   12. Sheng Guo
   13. Jiateng Zhong
   14. Zishan Yang
   15. Fei Tu
   16. Qianqing Wang
   17. Jin Bai
   18. Feng Ren
   19. Zhiwei Feng
   20. Huijie Jia

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This valuable study evaluates the effects of nifuroxazide on radiotherapy for the treatment of hepatocellular carcinoma. Solid evidence is provided to support the conclusion that nifuroxazide facilitates the downregulation of PD-L1 and may improve therapy outcomes when combined with radiotherapy, though the inclusion of additional cell lines and animal models would have strengthened the study. This work will be of interest to cancer biologists and those working in immuno-oncology.

   Reviewed by eLife

10. Metabolomics identifies and validates serum androstenedione as novel biomarker for diagnosing primary angle closure glaucoma and predicting the visual field progression

    This article has 11 authors:

    1. Shengjie Li
    2. Jun Ren
    3. Zhendong Jiang
    4. Yichao Qiu
    5. Mingxi Shao
    6. Yingzhu Li
    7. Jianing Wu
    8. Yunxiao Song
    9. Xinghuai Sun
    10. Shunxiang Gao
    11. Wenjun Cao

    This article has been curated by 1 group:

    • Curated by eLife

      eLife assessment

      This study presents a valuable finding that serum androstenedione levels may provide a new biomarker for early detection and progression of glaucoma, although a single biomarker is unlikely to be singularly predictive due to the etiological heterogeneity of the disease. The strength of the evidence presented is solid, supported by multiple lines of evidence.

    Reviewed by eLife