Latest preprint reviews

  1. Chromosome-level genome assembly of hadal snailfish reveals mechanisms of deep-sea adaptation in vertebrates

    This article has 16 authors:
    1. Wenjie Xu
    2. Chenglong Zhu
    3. Xueli Gao
    4. Baosheng Wu
    5. Han Xu
    6. Mingliang Hu
    7. Honghui Zeng
    8. Xiaoni Gan
    9. Chenguang Feng
    10. Jiangmin Zheng
    11. Jing Bo
    12. Li-Sheng He
    13. Qiang Qiu
    14. Wen Wang
    15. Shunping He
    16. Kun Wang
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This important study advances our understanding of the potential mechanisms of deep-sea adaptation and sheds light on the evolutionary history of hadal snailfish. Through comparative genomic analysis, the authors provide convincing evidence and propose hypotheses on the timing of trench colonization, population structure, and adaptations to the hadal snailfish genome in response to their environment.

    Reviewed by eLife

    This article has 7 evaluationsAppears in 1 listLatest version Latest activity
  2. Alternative end-joining results in smaller deletions in heterochromatin relative to euchromatin

    This article has 15 authors:
    1. Jacob M. Miller
    2. Sydney Prange
    3. Huanding Ji
    4. Alesandra R. Rau
    5. Varandt Y. Khodaverdian
    6. Xiao Li
    7. Avi Patel
    8. Nadejda Butova
    9. Avery Lutter
    10. Helen Chung
    11. Chiara Merigliano
    12. Chetan C. Rawal
    13. Terrence Hanscom
    14. Mitch McVey
    15. Irene Chiolo
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This manuscript describes valuable new findings on the impact of chromatin context on the outcomes of microhomology-mediated end joining of DNA double-strand breaks (DSBs), specifically a preference for DSB-proximal microhomologies in repair within a heterochromatic compared to a euchromatic locus. The authors develop the Drosophila spermatogonia as a model for repair at induced DSBs in a mitotically-active tissue and leverage this system to provide convincing evidence that the local environment impacts the preference for repair mechanism and outcome. The work could be strengthened by the use of additional euchromatin insertion(s) to robustly validate the findings.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
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