eLife

Latest preprint reviews

1. Dynamic landscape of the intracellular termini of acid-sensing ion channel 1a

   This article has 4 authors:

   1. Megan M Cullinan
   2. Robert C Klipp
   3. Abigail Camenisch
   4. John R Bankston

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This valuable study illuminates molecular movements of acid-sensing ion channels by combining advanced chemical biology and biophysical techniques. The evidence for the main claim, lack of interaction of molecular termini, is compelling and challenges prior models. This work is expected to pique interest in the ion channel signaling field, providing a fresh perspective.

   Reviewed by eLife

2. Deciphering the chemical language of inbred and wild mouse conspecific scents

   This article has 9 authors:

   1. Maximilian Nagel
   2. Marco Niestroj
   3. Rohini Bansal
   4. David Fleck
   5. Angelika Lampert
   6. Romana Stopkova
   7. Pavel Stopka
   8. Yoram Ben-Shaul
   9. Marc Spehr

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This carefully executed study provides a comparison of the chemical composition of mouse urine across strain and sex with the responses of vomeronasal sensory neurons, which are responsible for detecting chemical social cues. While the authors did not examine all molecular classes found in mouse urine or directly test whether the urinary volatile chemicals that vary with sex and strain are effective vomeronasal neuron ligands, solid data are provided that will be of significant interest to those studying chemical communication in rodents. This work should provide a valuable foundation for future research that will determine which molecules drive sex- and strain-specific vomeronasal responses.

   Reviewed by eLife

3. Precise spatial tuning of visually driven alpha oscillations in human visual cortex

   This article has 13 authors:

   1. Kenichi Yuasa
   2. Iris IA Groen
   3. Giovanni Piantoni
   4. Stephanie Montenegro
   5. Adeen Flinker
   6. Sasha Devore
   7. Orrin Devinsky
   8. Werner Doyle
   9. Patricia Dugan
   10. Daniel Friedman
   11. Nick F Ramsey
   12. Natalia Petridou
   13. Jonathan Winawer

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This intracranial EEG study presents important and convincing neural evidence supporting the high spatial specificity (receptive field) of visually driven alpha-band oscillation in human brains and its potential role in exogenous cuing attention. The work challenges the predominant view about the role of alpha-band oscillation in visual attention and advocates that stimulus-driven alpha suppression is precisely tuned and might contribute to exogenous spatial attention.

   Reviewed by eLife

4. Modeled grid cells aligned by a flexible attractor

   This article has 3 authors:

   1. Sabrina Benas
   2. Ximena Fernandez
   3. Emilio Kropff

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     In this valuable study, the authors use a computational model to investigate how recurrent connections influence the firing patterns of grid cells, which are thought to play a role in encoding an animal's position in space. The work suggests that a one-dimensional network architecture may be sufficient to generate the hexagonal firing patterns of grid cells, a possible alternative to attractor models based on recurrent connectivity between grid cells. However, the support for this proposal was incomplete, as some conclusions for how well the model dynamics are necessary to generate features of grid cell organization were not well supported.

   Reviewed by eLife

5. Postsynaptic mitochondria are positioned to support functional diversity of dendritic spines

   This article has 4 authors:

   1. Connon I Thomas
   2. Melissa A Ryan
   3. Naomi Kamasawa
   4. Benjamin Scholl

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study reports valuable findings on the correlation between the positions of dendritic mitochondria and the orientation preference of calcium responses of individual spines. The conclusion about the biased localization of dendritic mitochondria near functional diverse spines is informative to understand the functions of dendritic mitochondria. The experimental evidence supporting the conclusion is compelling.

   Reviewed by eLife

6. Large-scale animal model study uncovers altered brain pH and lactate levels as a transdiagnostic endophenotype of neuropsychiatric disorders involving cognitive impairment

   This article has 131 authors:

   1. Hideo Hagihara
   2. Hirotaka Shoji
   3. Satoko Hattori
   4. Giovanni Sala
   5. Yoshihiro Takamiya
   6. Mika Tanaka
   7. Masafumi Ihara
   8. Mihiro Shibutani
   9. Izuho Hatada
   10. Kei Hori
   11. Mikio Hoshino
   12. Akito Nakao
   13. Yasuo Mori
   14. Shigeo Okabe
   15. Masayuki Matsushita
   16. Anja Urbach
   17. Yuta Katayama
   18. Akinobu Matsumoto
   19. Keiichi I Nakayama
   20. Shota Katori
   21. Takuya Sato
   22. Takuji Iwasato
   23. Haruko Nakamura
   24. Yoshio Goshima
   25. Matthieu Raveau
   26. Tetsuya Tatsukawa
   27. Kazuhiro Yamakawa
   28. Noriko Takahashi
   29. Haruo Kasai
   30. Johji Inazawa
   31. Ikuo Nobuhisa
   32. Tetsushi Kagawa
   33. Tetsuya Taga
   34. Mohamed Darwish
   35. Hirofumi Nishizono
   36. Keizo Takao
   37. Kiran Sapkota
   38. Kazutoshi Nakazawa
   39. Tsuyoshi Takagi
   40. Haruki Fujisawa
   41. Yoshihisa Sugimura
   42. Kyosuke Yamanishi
   43. Lakshmi Rajagopal
   44. Nanette Deneen Hannah
   45. Herbert Y Meltzer
   46. Tohru Yamamoto
   47. Shuji Wakatsuki
   48. Toshiyuki Araki
   49. Katsuhiko Tabuchi
   50. Tadahiro Numakawa
   51. Hiroshi Kunugi
   52. Freesia L Huang
   53. Atsuko Hayata-Takano
   54. Hitoshi Hashimoto
   55. Kota Tamada
   56. Toru Takumi
   57. Takaoki Kasahara
   58. Tadafumi Kato
   59. Isabella A Graef
   60. Gerald R Crabtree
   61. Nozomi Asaoka
   62. Hikari Hatakama
   63. Shuji Kaneko
   64. Takao Kohno
   65. Mitsuharu Hattori
   66. Yoshio Hoshiba
   67. Ryuhei Miyake
   68. Kisho Obi-Nagata
   69. Akiko Hayashi-Takagi
   70. Léa J Becker
   71. Ipek Yalcin
   72. Yoko Hagino
   73. Hiroko Kotajima-Murakami
   74. Yuki Moriya
   75. Kazutaka Ikeda
   76. Hyopil Kim
   77. Bong-Kiun Kaang
   78. Hikari Otabi
   79. Yuta Yoshida
   80. Atsushi Toyoda
   81. Noboru H Komiyama
   82. Seth GN Grant
   83. Michiru Ida-Eto
   84. Masaaki Narita
   85. Ken-ichi Matsumoto
   86. Emiko Okuda-Ashitaka
   87. Iori Ohmori
   88. Tadayuki Shimada
   89. Kanato Yamagata
   90. Hiroshi Ageta
   91. Kunihiro Tsuchida
   92. Kaoru Inokuchi
   93. Takayuki Sassa
   94. Akio Kihara
   95. Motoaki Fukasawa
   96. Nobuteru Usuda
   97. Tayo Katano
   98. Teruyuki Tanaka
   99. Yoshihiro Yoshihara
   100. Michihiro Igarashi
   101. Takashi Hayashi
   102. Kaori Ishikawa
   103. Satoshi Yamamoto
   104. Naoya Nishimura
   105. Kazuto Nakada
   106. Shinji Hirotsune
   107. Kiyoshi Egawa
   108. Kazuma Higashisaka
   109. Yasuo Tsutsumi
   110. Shoko Nishihara
   111. Noriyuki Sugo
   112. Takeshi Yagi
   113. Naoto Ueno
   114. Tomomi Yamamoto
   115. Yoshihiro Kubo
   116. Rie Ohashi
   117. Nobuyuki Shiina
   118. Kimiko Shimizu
   119. Sayaka Higo-Yamamoto
   120. Katsutaka Oishi
   121. Hisashi Mori
   122. Tamio Furuse
   123. Masaru Tamura
   124. Hisashi Shirakawa
   125. Daiki X Sato
   126. Yukiko U Inoue
   127. Takayoshi Inoue
   128. Yuriko Komine
   129. Tetsuo Yamamori
   130. Kenji Sakimura
   131. Tsuyoshi Miyakawa

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     The manuscript offers useful descriptive insights into the potential influence of whole-brain lactate and pH levels on the manifestation of behavioral phenotypes seen in diverse animal models of neuropsychiatric disorders. However, reviewers have raised concerns about the potential loss of specificity in capturing regional and cell-type-specific effects when relying solely on whole-brain analysis methods. While the evidence supporting the conclusions is largely solid, the robustness of these conclusions could be enhanced by the inclusion of additional data and further analysis.

   Reviewed by eLife

7. Zona incerta distributes a broad movement signal that modulates behavior

   This article has 6 authors:

   1. Sebastian Hormigo
   2. Ji Zhou
   3. Dorian Chabbert
   4. Sarmad Sajid
   5. Natan Busel
   6. Manuel Castro-Alamancos

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important study uses a range of technical approaches to investigate the responses of zona incerta neurons to movement and sensory stimuli. The majority of neurons exhibited movement related activity but only a small proportion were modulated by whisker deflections. The major conclusion of the study is that the zona incerta distributes a general motor signal. The evidence supporting this claim is solid, although the study would be improved by greater transparency and discussion of experimental methods and histological verification of recording sites, viral spread, and which territories of the zona incerta were investigated. The work will be of interest to behavioral and physiological neuroscientists.

   Reviewed by eLife

8. New genetic tools for mushroom body output neurons in Drosophila

   This article has 2 authors:

   1. Gerald M Rubin
   2. Yoshinori Aso

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This work advances on two Aso et al 2014 eLife papers to describe further resources that are valuable for the field. This paper identified and contributes additional MBON split-Gal4s, convincingly describing their anatomy, connectivity and function.

   Reviewed by eLife

9. Trophic eggs affect caste determination in the ant Pogonomyrmex rugosus

   This article has 3 authors:

   1. Eléonore Genzoni
   2. Tanja Schwander
   3. Laurent Keller

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important manuscript by Genzoni et al. reports the striking discovery of a regulatory role for trophic eggs in ant caste determination. Prior to this study, trophic eggs were widely assumed to play only a nutritional role in the colony, but this compelling study shows that trophic eggs can suppress queen development, and therefore regulate caste determination in specific social contexts.

   Reviewed by eLife

10. Interdependence of plasma membrane nanoscale dynamics of a kinase and its cognate substrate underlies Arabidopsis response to viral infection

    This article has 22 authors:

    1. Marie-Dominique Jolivet
    2. Anne Flore Deroubaix
    3. Marie Boudsocq
    4. Nikolaj B Abel
    5. Marion Rocher
    6. Terezinha Robbe
    7. Valérie Wattelet-Boyer
    8. Jennifer Huard
    9. Dorian Lefebvre
    10. Yi-Ju Lu
    11. Brad Day
    12. Grégoire Saias
    13. Jahed Ahmed
    14. Valérie Cotelle
    15. Nathalie Giovinazzo
    16. Jean-Luc Gallois
    17. Yasuyuki Yamaji
    18. Sylvie German-Retana
    19. Julien Gronnier
    20. Thomas Ott
    21. Sébastien Mongrand
    22. Véronique Germain

    This article has been curated by 1 group:

    • Curated by eLife

      eLife Assessment

      The study is considered important with solid evidence that demonstrates the impact of plasma membrane nano-domains and protein interactions in the plant defence response to viruses. It includes a molecular understanding of the role of a calcium dependent kinase (CPK3) and a remorin protein in the cell-to-cell spread of viruses and cytoskeletal dynamics demonstrating, conclusively, the role of CPK3 with multiple lines of evidence. The work opens avenues to investigate different viruses and other plasma membrane proteins to gain a fuller picture of the involvement of plasmodesmata and other nanodomains in virus spreading.

    Reviewed by eLife