eLife

Latest preprint reviews

1. Phosphorylation bar-coding of free fatty acid receptor 2 is generated in a tissue-specific manner

   This article has 13 authors:

   1. Natasja Barki
   2. Laura Jenkins
   3. Sara Marsango
   4. Domonkos Dedeo
   5. Daniele Bolognini
   6. Louis Dwomoh
   7. Aisha M Abdelmalik
   8. Margaret Nilsen
   9. Manon Stoffels
   10. Falko Nagel
   11. Stefan Schulz
   12. Andrew B Tobin
   13. Graeme Milligan

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     In this study, the authors present important tools for monitoring distinct tissue-specific patterns of agonist-induced Free Fatty Acid receptor 2 phosphorylation. The work includes several validation experiments, which provide convincing evidence that will be beneficial for the scientific community.

   Reviewed by eLife

2. Endogenous oscillatory rhythms and interactive contingencies jointly influence infant attention during early infant-caregiver interaction

   This article has 9 authors:

   1. Emily AM Phillips
   2. Louise Goupil
   3. Megan Whitehorn
   4. Emma Bruce-Gardyne
   5. Florian A Csolsim
   6. Navsheen Kaur
   7. Emily Greenwood
   8. Ira Marriott Haresign
   9. Sam V Wass

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study reports important evidence that infants' internal factors guide children's attention, and that caregivers respond to infants' attentional shifts during caregiver-infant interactions. The authors analyzed EEG data and multiple types of behaviors using solid methodologies that can guide future studies of neural responses during social interaction in infants.

   Reviewed by eLife

3. Repurposing the mammalian RNA-binding protein Musashi-1 as an allosteric translation repressor in bacteria

   This article has 14 authors:

   1. Roswitha Dolcemascolo
   2. María Heras-Hernández
   3. Lucas Goiriz
   4. Roser Montagud-Martínez
   5. Alejandro Requena-Menéndez
   6. Raúl Ruiz
   7. Anna Pérez-Ràfols
   8. R Anahí Higuera-Rodríguez
   9. Guillermo Pérez-Ropero
   10. Wim F Vranken
   11. Tommaso Martelli
   12. Wolfgang Kaiser
   13. Jos Buijs
   14. Guillermo Rodrigo

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study demonstrates the use of the mammalian Musashi-1 (MSI-1) RNA-binding protein as a tool for regulating gene expression in Escherichia coli. The authors provide convincing evidence that MSI-1 functions as an effective repressor of translation, and that MSI-1 can be allosterically controlled by oleic acid. This work establishes MSI-1 as a potential tool for synthetic biology applications, and the system developed here can be used for mechanistic studies of MSI-1.

   Reviewed by eLife

4. The title and authors for this article are not available from our external data provider yet:
   10.48550/arxiv.2302.14157v1

5. Inhibition of the serine protease HtrA1 by SerpinE2 suggests an extracellular proteolytic pathway in the control of neural crest migration

   This article has 5 authors:

   1. Edgar M Pera
   2. Josefine Nilsson-De Moura
   3. Yuriy Pomeshchik
   4. Laurent Roybon
   5. Ivana Milas

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This fundamental work substantially advances our understanding of cell migration, especially in that of cranial neural crest. The additional evidence provided to support the conclusion is exceptional, with rigorous biochemical assays for materials used and with intensive genetic interventions. The work will be of broad interest to developmental biologists and cell biologists.

   Reviewed by eLife

6. Role of the αC-β4 loop in protein kinase structure and dynamics

   This article has 7 authors:

   1. Jian Wu
   2. Nisha A Jonniya
   3. Sophia P Hirakis
   4. Cristina Olivieri
   5. Gianluigi Veglia
   6. Alexandr P Kornev
   7. Susan S Taylor

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This valuable study draws attention to the importance of a previously overlooked structural motif in kinase regulation. While the data presented are intriguing and mostly solid, further analysis and additional experiments will be needed in the future to support the authors' hypothesis. The work will be of interest to protein biochemists and enzymologists with an interest in kinases and allostery.

   Reviewed by eLife

7. Genetic code expansion, click chemistry, and light-activated PI3K reveal details of membrane protein trafficking downstream of receptor tyrosine kinases

   This article has 12 authors:

   1. Duk-Su Koh
   2. Anastasiia Stratiievska
   3. Subhashis Jana
   4. Shauna C Otto
   5. Teresa M Swanson
   6. Anthony Nhim
   7. Sara Carlson
   8. Marium Raza
   9. Ligia Araujo Naves
   10. Eric N Senning
   11. Ryan A Mehl
   12. Sharona E Gordon

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study develops a new and important method for dissecting out two overlapping cell signaling pathways, phosphoinositide signaling and membrane protein trafficking. The combination of two state-of-the-art spectroscopic techniques provides compelling evidence for a reciprocal influence between an enzyme and a channel. The work will be of interest to the broader cell biology, biophysics and biochemistry communities.

   Reviewed by eLife

8. Genetic code expansion, click chemistry, and light-activated PI3K reveal details of membrane protein trafficking downstream of receptor tyrosine kinases

   This article has 12 authors:

   1. Duk-Su Koh
   2. Anastasiia Stratiievska
   3. Subhashis Jana
   4. Shauna C Otto
   5. Teresa M Swanson
   6. Anthony Nhim
   7. Sara Carlson
   8. Marium Raza
   9. Ligia Araujo Naves
   10. Eric N Senning
   11. Ryan A Mehl
   12. Sharona E Gordon

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study develops a new and important method for dissecting out two overlapping cell signaling pathways, phosphoinositide signaling and membrane protein trafficking. The combination of two state-of-the-art spectroscopic techniques provides compelling evidence for a reciprocal influence between an enzyme and a channel. The work will be of interest to the broader cell biology, biophysics and biochemistry communities.

   Reviewed by eLife

9. Potassium-mediated bacterial chemotactic response

   This article has 3 authors:

   1. Chi Zhang
   2. Rongjing Zhang
   3. Junhua Yuan

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     In this important study, the authors report a novel measurement of the Escherichia coli chemotactic response and demonstrate that these bacteria display an attractant response to potassium, which is connected to intracellular pH level. The experimental evidence provided is convincing and the work will be of interest to microbiologists studying chemotaxis.

   Reviewed by eLife

10. Guanidine production by plant homoarginine-6-hydroxylases

    This article has 4 authors:

    1. Dietmar Funck
    2. Malte Sinn
    3. Giuseppe Forlani
    4. Jörg S Hartig

    This article has been curated by 1 group:

    • Curated by eLife

      eLife assessment

      This fundamental study advances our understanding of nitrogen metabolism by identifying a new type of guanidine-forming enzyme in eukaryotes. The key claims of the article are convincingly supported by the data, with meticulous biochemical, cellular, and in vivo studies on guanidine production. The work will stimulate interest in the cellular roles of homoarginine, and, more generally, in the biochemistry and metabolism of guanidine derivatives.

    Reviewed by eLife