eLife

Latest preprint reviews

1. IS200/IS605 Family-Associated TnpB Increases Transposon Activity and Retention

   This article has 2 authors:

   1. Davneet Kaur
   2. Thomas E. Kuhlman

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important study uses an innovative set of reporter assays to probe the role of the TnpB protein in IS608 transposition. The work provides independent support for the recently reported homing activity of TnpB, where the transposon is restored following excision, and suggests an additional function for TnpB in enhancing the transposase activity of the TnpA transposase. The overall approach is solid, but the authors should consider how the activity of the TnpB protein used, or the levels of ωRNA, impact their model.

   Reviewed by eLife

2. Maresin 1 repletion improves muscle regeneration after volumetric muscle loss

   This article has 13 authors:

   1. Jesus A Castor-Macias
   2. Jacqueline A Larouche
   3. Emily C Wallace
   4. Bonnie D Spence
   5. Alec Eames
   6. Pamela Duran
   7. Benjamin A Yang
   8. Paula M Fraczek
   9. Carol A Davis
   10. Susan V Brooks
   11. Krishna Rao Maddipati
   12. James F Markworth
   13. Carlos A Aguilar

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This is a compelling study on pro-inflammatory and anti-inflammatory lipids in relation to skeletal muscle injury. It convincingly identifies pro-inflammatory lipids during recovery predisposing to fibrosis, and maresin 1 as an anti-inflammatory lipid reducing fibrosis, improved muscle regeneration, partially restoring contractile function, of fundamental potential clinical application.

   Reviewed by eLife

3. We couldn't get details of this article at this time:
   10.1101/2022.08.30.505807

4. We couldn't get details of this article at this time:
   10.1101/2022.08.10.503541

5. Enhanced KNa1.1 Channel Underlies Cortical Hyperexcitability and Seizure Susceptibility after Traumatic Brain Injury

   This article has 7 authors:

   1. Ru Liu
   2. Lei Sun
   3. Le Du
   4. Xi Guo
   5. Meng Jia
   6. Qun Wang
   7. Jianping Wu

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This potentially valuable study provides some evidence that upregulation of sodium-activated potassium channels contributes to neuronal hyperexcitability and seizures following traumatic brain injury. However, the evidence supporting a direct link is incomplete. This work will be of interest to epilepsy and ion channel researchers.

   Reviewed by eLife

6. We couldn't get details of this article at this time:
   10.1101/2023.10.09.561535

7. We couldn't get details of this article at this time:
   10.1101/2023.08.23.554334

8. We couldn't get details of this article at this time:
   10.1101/2023.08.21.554194

9. We couldn't get details of this article at this time:
   10.1101/2023.03.02.530772

10. We couldn't get details of this article at this time:
    10.1101/2021.06.18.448959