eLife

Latest preprint reviews

1. Genetic and pharmacologic alterations of claudin9 levels suffice to induce functional and mature inner hair cells

   This article has 13 authors:

   1. Yingying Chen
   2. Jeong Han Lee
   3. Jin Li
   4. Seojin Park
   5. Maria C Perez Flores
   6. Braulio Peguero
   7. Jennifer Kersigo
   8. Mincheol Kang
   9. Jinsil Choi
   10. Lauren Levine
   11. Michael Anne Gratton
   12. Bernd Fritzsch
   13. Ebenezer N Yamoah

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This valuable study reports the induction of supernumerary inner hair cells in the mouse cochlea upon reducing the expression level of a tight-junction protein (claudin-9) at developmental stages. Although these ectopic hair cells are functional and persists through adulthood, the evidence supporting some of the claims is incomplete, particularly regarding the underlying mechanisms of cell differentiation and the potential of the approach for hair-cell regeneration. The work will be of interest to scientists working in the development and regeneration of hair cells in the inner ear.

   Reviewed by eLife

2. We couldn't get details of this article at this time:
   10.1101/2023.08.29.555311

3. We couldn't get details of this article at this time:
   10.1101/2023.10.05.561003

4. We couldn't get details of this article at this time:
   10.1101/2023.09.24.23295907

5. Computational Engineering of a Therapeutic Antibody to Inhibit Multiple Mutants of HER2 Without Compromising Inhibition of the Canonical HER2

   This article has 7 authors:

   1. Sapir Peled
   2. Julia Guez-Haddad
   3. Nevet Zur Biton
   4. Guy Nimrod
   5. Sharon Fischman
   6. Yair Fastman
   7. Yanay Ofran

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     In this important manuscript, the authors used unbiased approaches to identify somatic mutations in publicly available databases that would disrupt clinically approved antibodies targeting HER2. Using a solid combination of both computational and experimental approaches they identify mutations that could restore therapeutic antibody sensitivity in a series of disease-relevant model systems. Additional cell-based and in vivo assays would strengthen the work and increase the translational and potential clinical relevance of the proposed work.

   Reviewed by eLife

6. We couldn't get details of this article at this time:
   10.1101/2023.05.23.541978

7. We couldn't get details of this article at this time:
   10.1101/2023.10.02.560590

8. We couldn't get details of this article at this time:
   10.1101/2023.10.02.560529

9. We couldn't get details of this article at this time:
   10.1101/2023.05.18.23290210

10. We couldn't get details of this article at this time:
    10.1101/2023.07.18.549568