eLife

Latest preprint reviews

1. Synaptic interactions between stellate cells and parvalbumin interneurons in layer 2 of the medial entorhinal cortex are organized at the scale of grid cell clusters

   This article has 4 authors:

   1. Li-Wen Huang
   2. Derek LF Garden
   3. Christina McClure
   4. Matthew F Nolan

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     In this compelling study, the authors examine the interactions between stellate cells and PV+ interneurons in the medial entorhinal cortex. Huang et al. focus on the spatial distribution of synaptic inputs and demonstrate that closely located neuron pairs receive common inputs, suggesting a structured functional organization in the entorhinal cortex. Advanced dual whole-cell patch recordings further reveal patterns of postsynaptic activation, indicating intensive interactions within clusters of these neurons, with weaker interactions between clusters. These findings offer significant insights into the functional dynamics of the entorhinal cortex and the circuit mechanisms that shape grid cell activity. This study is important not only for the field of MEC and grid cells, but also for broader fields of continuous attractor networks and neural circuits.

   Reviewed by eLife

2. Microprism-based two-photon imaging of the mouse inferior colliculus reveals novel organizational principles of the auditory midbrain

   This article has 6 authors:

   1. Baher A Ibrahim
   2. Yoshitaka Shinagawa
   3. Austin Douglas
   4. Gang Xiao
   5. Alexander R Asilador
   6. Daniel A Llano

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study provides valuable new insights into how multisensory information is processed in the lateral cortex of the inferior colliculus, a poorly understood part of the auditory midbrain. By developing new imaging techniques that provide the first optical access to the lateral cortex in a living animal, the authors provide convincing in vivo evidence that this region contains separate subregions that can be distinguished by their sensory inputs and neurochemical profiles, as suggested by previous anatomical and in vitro studies. This work provides a foundation for future research exploring how this part of the auditory midbrain contributes to multisensory-based behavior.

   Reviewed by eLife

3. Brain state and cortical layer-specific mechanisms underlying perception at threshold

   This article has 6 authors:

   1. Mitchell P Morton
   2. Sachira Denagamage
   3. Isabel J Blume
   4. John H Reynolds
   5. Monika P Jadi
   6. Anirvan S Nandy

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This useful study by Nandy and colleagues examined relationships between behavioral state, neural activity in cortical area V4, and trial-by-trial variability in the ability to detect weak visual stimuli. They present solid evidence indicating that certain changes in arousal and eye-position stability, along with patterns of synchrony in the activity of neurons in different layers of V4, can show modest correspondences to changes in the ability to correctly detect a stimulus. These findings are likely to be of interest to those who seek a deeper understanding of circuit mechanisms that underlie perception.

   Reviewed by eLife

4. Antipsychotic-induced epigenomic reorganization in frontal cortex of individuals with schizophrenia

   This article has 11 authors:

   1. Bohan Zhu
   2. Richard I Ainsworth
   3. Zengmiao Wang
   4. Zhengzhi Liu
   5. Salvador Sierra
   6. Chengyu Deng
   7. Luis F Callado
   8. J Javier Meana
   9. Wei Wang
   10. Chang Lu
   11. Javier González-Maeso

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     The study by Zhu et al. provides important insights into cell-specific genome-wide histone modifications in the frontal cortex of individuals with schizophrenia, as well as shedding light on the role of age and antipsychotic treatment in these associations. The evidence supporting the conclusions is solid.

   Reviewed by eLife

5. Evolutionary rate covariation is a reliable predictor of co-functional interactions but not necessarily physical interactions

   This article has 3 authors:

   1. Jordan Little
   2. Maria Chikina
   3. Nathan L Clark

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This useful study seeks to address the importance of physical interaction between proteins in higher-order complexes for covariation of evolutionary rates at different sites in these interacting proteins. Following up on a previous analysis with a smaller dataset, the authors provide compelling evidence that the exact contribution of physical interactions, if any, remains difficult to quantify. The work will be of relevance to anyone interested in protein evolution.

   Reviewed by eLife

6. Dynamic localization of the chromosomal passenger complex in trypanosomes is controlled by the orphan kinesins KIN-A and KIN-B

   This article has 2 authors:

   1. Daniel Ballmer
   2. Bungo Akiyoshi

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important study identifies the mitotic localization mechanism for Aurora B and INCENP (parts of the chromosomal passenger complex, CPC) in Trypanosoma brucei. The mechanism differs from that in the more commonly studied opisthokonts and is supported by compelling RNAi and imaging experiments, targeted mutations, immunoprecipitations with crosslinking/mass spec, and AlphaFold interaction predictions. The findings will be of interest to cell biologists working on cell division, parasitologists, and those interested in the evolution of mitotic mechanisms.

   Reviewed by eLife

7. MAFB drives differentiation by permitting WT1 binding to podocyte specific promoters

   This article has 11 authors:

   1. Filippo M. Massa
   2. Fariba Jian-Motamedi
   3. Marijus Šerys
   4. Amelie Tison
   5. Agnès Loubat
   6. Sandra Lacas-Gervais
   7. Luc Martin
   8. Hassiba Belahbib
   9. Sandrine Sarrazin
   10. Michael H. Sieweke
   11. Andreas Schedl

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study presents valuable insights into the epigenetic landscape in adult kidney podocytes. A series of solid experiments demonstrate that genes that are regulated by a key kidney transcription factor, Mafb, are essential for H3K4me3 methylation and recruitment of Wt1 to Nphs1 and Nphs2. This new information provides insights into the potential relationship and coordination of transcription factors in regulating target genes in podocytes in glomerular diseases, although the conclusion that MafB is generally required for Wt1 to bind to podocyte-specific promoters is incomplete and should be extended beyond two or three genes.

   Reviewed by eLife

8. A kidney-hypothalamus axis promotes compensatory glucose production in response to glycosuria

   This article has 9 authors:

   1. Tumininu S Faniyan
   2. Xinyi Zhang
   3. Donald A Morgan
   4. Jorge Robles
   5. Siresha Bathina
   6. Paul S Brookes
   7. Kamal Rahmouni
   8. Rachel J Perry
   9. Kavaljit H Chhabra

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     The study presents valuable findings on compensatory mechanisms in response to glycosuria. The evidence supporting the claims is solid, although a causal relationship is somewhat uncertain and the addition of a more clinically relevant model would have strengthened the findings. The work will be of interest to diabetes investigators.

   Reviewed by eLife, PREreview

9. Early moderate prenatal alcohol exposure and maternal diet impact offspring DNA methylation across species

   This article has 15 authors:

   1. Mitchell Bestry
   2. Alexander N Larcombe
   3. Nina Kresoje
   4. Emily K Chivers
   5. Chloe Bakker
   6. James P Fitzpatrick
   7. Elizabeth J Elliott
   8. Jeffrey M Craig
   9. Evelyne Muggli
   10. Jane Halliday
   11. Delyse Hutchinson
   12. Sam Buckberry
   13. Ryan Lister
   14. Martyn Symons
   15. David Martino

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important study unveils the significant impact of prenatal alcohol exposure on epigenetic patterns, offering new insights into its adverse health outcomes through solid evidence from both mouse models and human data. The findings, which reveal how a high-methyl diet can mitigate these epigenetic alterations, present a promising prenatal care strategy. Despite its solid data overall, the study's small sample size and unaccounted confounders suggest the need for further research to confirm these findings and explore their practical implications.

   Reviewed by eLife

10. A latent clinical-anatomical dimension relating metabolic syndrome to brain structure and cognition

    This article has 17 authors:

    1. Marvin Petersen
    2. Felix Hoffstaedter
    3. Felix L Nägele
    4. Carola Mayer
    5. Maximilian Schell
    6. D Leander Rimmele
    7. Birgit-Christiane Zyriax
    8. Tanja Zeller
    9. Simone Kühn
    10. Jürgen Gallinat
    11. Jens Fiehler
    12. Raphael Twerenbold
    13. Amir Omidvarnia
    14. Kaustubh R Patil
    15. Simon B Eickhoff
    16. Goetz Thomalla
    17. Bastian Cheng

    This article has been curated by 1 group:

    • Curated by eLife

      eLife assessment

      This important work contributes to our understanding of the combined effects of metabolic syndrome on fronto-temporal gray matter morphology from two large-scale datasets. The evidence based on state-of-the art multivariate imaging analysis and detailed micro- and macrostructural contextualization analyses is convincing and provides an understanding of the neurological correlates of metabolic syndrome, although the study would have benefitted from the inclusion of longitudinal data.

    Reviewed by eLife