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  1. Mapping variation in the morphological landscape of human cells with optical pooled CRISPRi screening

    This article has 8 authors:
    1. Ramon Lorenzo D. Labitigan
    2. Adrian L. Sanborn
    3. Cynthia V. Hao
    4. Caleb K. Chan
    5. Nathan M. Belliveau
    6. Eva M. Brown
    7. Mansi Mehrotra
    8. Julie A. Theriot
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      In this important study by Theriot et al., the authors utilize an impressive set of innovative approaches to conduct a CRISPRi pooled screen in human cells using large-scale microscopy screen data. They leverage an improved barcoding approach to identify genes targeted in specific cells and examine the effects on cell morphology using high-dimensional phenotypic analysis. The method and data presented are compelling.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
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