eLife

Latest preprint reviews

1. Resource-rational account of sequential effects in human prediction

   This article has 3 authors:

   1. Arthur Prat-Carrabin
   2. Florent Meyniel
   3. Rava Azeredo da Silveira

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This work is relevant to understanding how people represent uncertain events in the world around them and make decisions, with broad applications to economic behavior. It addresses a long-standing empirical puzzle from a novel perspective, where the authors propose that sequential effects in perceptual decisions may emerge from rational choices under cognitive resource constraints rather than adjustments to changing environments. Two new computational models have been constructed to predict behavior under two different constraints, among which the one assuming higher cost for more precise beliefs is better supported by new experimental data. The conclusion may be further strengthened by comparison with alternative models and (optionally) evidence from additional data.

   Reviewed by eLife

2. High-throughput mapping of single-neuron projection and molecular features by retrograde barcoded labeling

   This article has 15 authors:

   1. Peibo Xu
   2. Jian Peng
   3. Tingli Yuan
   4. Zhaoqin Chen
   5. Hui He
   6. Ziyan Wu
   7. Ting Li
   8. Xiaodong Li
   9. Luyue Wang
   10. Le Gao
   11. Jun Yan
   12. Wu Wei
   13. Chengyu T Li
   14. Zhen-Ge Luo
   15. Yuejun Chen

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This manuscript describes a valuable new circuit mapping and profiling technique called Multiplexed projEction neuRons retrograde barcodE (MERGEseq) that combines transcriptome and projectome data at a single-cell resolution. The authors provide solid evidence that MERGEseq can be used to identify projection targets and cell type/layer/transcriptome differences of projection neurons in the mouse prefrontal cortex, and validation experiments are rigorous. While this report is a proof-of-principle that MERGEseq is useful for circuit mapping and profiling and many potential details will influence conclusions, this technique could easily be adapted to other regions with known projection targets and adds to a growing arsenal of combinatorial circuit mapping and profiling tools.

   Reviewed by eLife

3. Dopamine lesions alter the striatal encoding of single-limb gait

   This article has 5 authors:

   1. Long Yang
   2. Deepak Singla
   3. Alexander K Wu
   4. Katy A Cross
   5. Sotiris C Masmanidis

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This valuable work extends previous studies showing that the striatum multiplexes various aspects of locomotion, including velocity and movement transitions, by demonstrating that striatal neurons also encode single-limb gait. The authors present solid evidence to show that gait deficits induced by severe unilateral dopamine depletion are associated with an imbalance in the gait modulation of striatal firing. Although the source and function of this gait modulation remain unclear, this manuscript uncovers a role of striatal activity in gait, which may have implications for understanding gait disturbances in Parkinson's Disease.

   Reviewed by eLife

4. Key determinants of the dual clamp/activator function of Complexin

   This article has 7 authors:

   1. Mazen Makke
   2. Alejandro Pastor-Ruiz
   3. Antonio Yarzagaray
   4. Surya Gaya
   5. Michelle Zimmer
   6. Walentina Frisch
   7. Dieter Bruns

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important work shows compelling data that significantly advances our understanding of the regulation of neurotransmitter and hormone secretion by exploring the mechanisms of how the protein complexin 2 (Cplx2) interacts with the calcium sensor synaptotagmin. The function of mammalian Cplx2 is studied using chromaffin cells derived from Cplx2 knock out mice as a system to overexpress and functionally characterize mutant Cplx2 forms and the interaction between Cplx2 and synaptotagmin. The authors identify structural requirements within the protein for Cplx's dual role in preventing premature vesicle exocytosis and enhancing evoked exocytosis. The findings are of broad interest to neuroscientists and cell biologists.

   Reviewed by eLife

5. Multi-day neuron tracking in high-density electrophysiology recordings using earth mover’s distance

   This article has 6 authors:

   1. Augustine Xiaoran Yuan
   2. Jennifer Colonell
   3. Anna Lebedeva
   4. Michael Okun
   5. Adam S Charles
   6. Timothy D Harris

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important study proposes a new method for tracking neurons recorded with Neuropixel electrodes across days. The methods and the strength of the evidence are convincing, but the authors do not address whether their approach can be generalized to other brain areas, species, behaviors, or tools. Overall, this method will be potentially of interest to many neuroscientists who want to study long-term activity changes of individual neurons in the brain.

   Reviewed by eLife

6. Whole-brain in situ mapping of neuronal activation in Drosophila during social behaviors and optogenetic stimulation

   This article has 3 authors:

   1. Kiichi Watanabe
   2. Hui Chiu
   3. David J Anderson

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This work reports an important new method for activity-dependent neuronal labeling in Drosophila using in situ hybridization, with the potential to establish a new standard in the field. The authors demonstrate the method's applicability by generating compelling evidence of the function of male-specific neurons in both aggression and courtship behaviors. These results and the new method will be of great interest to the neuroscience community.

   Reviewed by eLife

7. mitoBKCa is functionally expressed in murine and human breast cancer cells and potentially contributes to metabolic reprogramming

   This article has 23 authors:

   1. Helmut Bischof
   2. Selina Maier
   3. Piotr Koprowski
   4. Bogusz Kulawiak
   5. Sandra Burgstaller
   6. Joanna Jasińska
   7. Kristian Serafimov
   8. Monika Zochowska
   9. Dominic Gross
   10. Werner Schroth
   11. Lucas Matt
   12. David Arturo Juarez Lopez
   13. Ying Zhang
   14. Irina Bonzheim
   15. Florian A Büttner
   16. Falko Fend
   17. Matthias Schwab
   18. Andreas L Birkenfeld
   19. Roland Malli
   20. Michael Lämmerhofer
   21. Piotr Bednarczyk
   22. Adam Szewczyk
   23. Robert Lukowski

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     The large-conductance Ca2+ activated K+ channel BKCa has been reported to promote breast cancer progression. The present study presents convincing evidence that an intracellular subpopulation of this channel reprograms breast cancer cells towards the Warburg phenotype, one of the metabolic hallmarks of cancer. This important finding advances the field of cancer cell metabolism and has potential therapeutic implications.

   Reviewed by eLife

8. A hepatocyte-specific transcriptional program driven by Rela and Stat3 exacerbates experimental colitis in mice by modulating bile synthesis

   This article has 12 authors:

   1. Jyotsna
   2. Binayak Sarkar
   3. Mohit Yadav
   4. Alvina Deka
   5. Manasvini Markandey
   6. Priyadarshini Sanyal
   7. Perumal Nagarajan
   8. Nilesh Gaikward
   9. Vineet Ahuja
   10. Debasisa Mohanty
   11. Soumen Basak
   12. Rajesh S Gokhale

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     The current version of the study presents important findings on how the RelA/Stat3-dependent gene program in the liver influences intestinal homeostasis. The evidence supporting the conclusions is solid, with new data added compared to an earlier version of the study. The work will be of interest to scientists in gastrointestinal research fields.

   Reviewed by eLife

9. Knock-down of a regulatory barcode shifts macrophage polarization destination from M1 to M2 and increases pathogen burden upon S. aureus infection

   This article has 6 authors:

   1. Sathyabaarathi Ravichandran
   2. Bharat Bhatt
   3. Awantika Shah
   4. Debajyoti Das
   5. Kithiganahalli Narayanaswamy Balaji
   6. Nagasuma Chandra

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     The authors of this manuscript study the transcriptional regulators that allow macrophages to assume different functional phenotypes in response to immune stimuli. They generate a computational map of the gene regulatory networks involved in determining macrophage phenotypes and experimentally validate the role of putative regulatory factors in a myeloid cell line. This study represents a valuable approach to understanding how gene regulation impacts macrophage polarization and their conclusions are supported by solid computational and experimental evidence. The revision has clarified that the focus is the identification of the regulatory barcodes in a myeloid cell line. Future studies in primary cells and in vivo will be required to assess the roles of these regulators in a broader context.

   Reviewed by eLife

10. The title and authors for this article are not available from our external data provider yet:
    10.31219/osf.io/preprints/psyarxiv