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   10.1101/2023.02.21.529403

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   10.1101/2022.09.05.506587

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   10.1101/2022.08.30.503982

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   10.1101/2022.01.01.474690

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   10.1101/2021.10.22.465432

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   10.1101/2023.11.28.569102

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   10.1101/2023.11.02.565285

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   10.1101/2023.11.01.565184

9. Coevolution with toxic prey produces functional trade-offs in sodium channels of predatory snakes

   This article has 9 authors:

   1. Robert E. del Carlo
   2. Jessica S. Reimche
   3. Haley A. Moniz
   4. Michael T.J. Hague
   5. Shailesh R. Agarwal
   6. Edmund D. Brodie
   7. Edmund D. Brodie
   8. Normand Leblanc
   9. Chris R. Feldman

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This valuable study describes an investigation of the properties of two heterologously-expressed Nav1.4 channels, with mutations close to the selectivity filter found in tetrodotoxin(TTX)-resistant snakes. The authors studied these mutants by electrophysiological methods, assessed the muscle properties of two types of snakes bearing these mutations, and built homology models of the channels to hypothesize a molecular explanation of the altered channel properties. The methods employed and the results are generally solid, although some aspects would benefit from additional experiments and a more nuanced discussion.

   Reviewed by eLife

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    10.1101/2023.12.08.570758