eLife

Latest preprint reviews

1. STAT3 is a genetic modifier of TGF-beta induced EMT in KRAS mutant pancreatic cancer

   This article has 4 authors:

   1. Stephen D'Amico
   2. Varvara Kirillov
   3. Oleksi Petrenko
   4. Nancy C Reich

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study delves into the complex role of STAT3 signaling and its interplay with TGF-beta and SMAD4 in KRAS mutant pancreatic cancer. The authors demonstrate that both the presence and absence of STAT3, relative to SMAD4, can lead to poor PDAC differentiation and that STAT3 mutations affect p53-null fibroblasts with KRASG12D and induce an EMT-like phenotype. By providing convincing evidence, the authors were able to derive important insights into KRAS mutant cancers.

   Reviewed by eLife

2. SCC3 is an axial element essential for homologous chromosome pairing and synapsis

   This article has 12 authors:

   1. Yangzi Zhao
   2. Lijun Ren
   3. Tingting Zhao
   4. Hanli You
   5. Yongjie Miao
   6. Huixin Liu
   7. Lei Cao
   8. Bingxin Wang
   9. Yi Shen
   10. Yafei Li
   11. Ding Tang
   12. Zhukuan Cheng

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This fundamental study elucidates the function of the cohesin subunit SCC3 in maintaining homologous chromosome pairing and synapsis during meiosis. The observation of sterility in the SCC3 weak mutant prompted an investigation of abnormal chromosome behavior during anaphase I, and the discovery that SCC3's loading onto meiotic chromosomes is REC8-dependent. The convincing evidence presented in this study contributes to our understanding of meiosis in rice and attracts cell biologists, reproductive biologists, and plant geneticists.

   Reviewed by eLife

3. CEP44 is required for maintaining centriole duplication and spindle integrity

   This article has 9 authors:

   1. Donghui Zhang
   2. Wenlu Wei
   3. Xiaopeng Zou
   4. Hui Meng
   5. Fangyuan Li
   6. Minjun Yao
   7. Junling Teng
   8. Ning Huang
   9. Jianguo Chen

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This useful study investigates the role of the centrosomal protein CEP44 in centriole duplication and mitotic spindle formation. While the analysis of CEP44 mitotic phosphorylation and spindle recruitment is solid, the characterization of CEP44's role at centrioles is incomplete and would benefit from additional controls and analyses. Since the work links CEP44 reduced expression to poor survival in breast cancer patients, it is of interest not only to cell biologists but also to cancer researchers.

   Reviewed by eLife

4. Loss of CTRP10 results in female obesity with preserved metabolic health

   This article has 7 authors:

   1. Fangluo Chen
   2. Dylan C Sarver
   3. Muzna Saqib
   4. Leandro M Velez
   5. Susan Aja
   6. Marcus M Seldin
   7. G William Wong

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This manuscript presents a detailed characterization of male and female wildtype and Ctrp10 knockout mice, and reveals that knockout mice develop female-specific obesity that is largely uncoupled from metabolic dysfunction. The data are convincing, and the work will be an important contribution to understanding how obesity is coupled to metabolic dysfunction, and how this can occur in a sex-specific manner.

   Reviewed by eLife

5. Reassessing the substrate specificities of the major Staphylococcus aureus peptidoglycan hydrolases lysostaphin and LytM

   This article has 7 authors:

   1. Lina Antenucci
   2. Salla Virtanen
   3. Chandan Thapa
   4. Minne Jartti
   5. Ilona Pitkänen
   6. Helena Tossavainen
   7. Perttu Permi

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This manuscript describes a valuable study aimed at identifying the substrate specificity of two cell wall hydrolases LSS and LytM in S. aureus. The authors show that LytM has a novel function of cleaving D-Ala-Gly instead of only Gly-Gly by using synthetic substrates and compelling NMR-based real-time kinetics measurements.

   Reviewed by eLife

6. Prolonged cell cycle arrest in response to DNA damage in yeast requires the maintenance of DNA damage signaling and the spindle assembly checkpoint

   This article has 7 authors:

   1. Felix Y Zhou
   2. David P Waterman
   3. Marissa Ashton
   4. Suhaily Caban-Penix
   5. Gonen Memisoglu
   6. Vinay V Eapen
   7. James E Haber

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This is an important study on the damage-induced checkpoint maintenance and termination in budding yeast that provides novel and convincing evidence for a role of the spindle assembly checkpoint and mitotic exit network in halting the cell cycle after prolonged arrest in response to irreparable DNA double strand breaks (DSBs). The study identifies particular components from these checkpoints that are specifically required for the establishment and/or the maintenance of a cell cycle block triggered by such DSBs. The authors propose an interesting model for how these different checkpoints intersect and crosstalk for timely resumption of cell cycling even without repairing DNA damage that has been revised by addressing the bulk of the reviewers' comments to the first version of the manuscript.

   Reviewed by eLife

7. Quantitative mapping of proteasome interactomes and substrates using ProteasomeID

   This article has 12 authors:

   1. Aleksandar Bartolome
   2. Julia C Heiby
   3. Domenico Di Fraia
   4. Ivonne Heinze
   5. Hannah Knaudt
   6. Ellen Spaeth
   7. Omid Omrani
   8. Alberto Minetti
   9. Maleen Hofmann
   10. Joanna M Kirkpatrick
   11. Therese Dau
   12. Alessandro Ori

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study presents an important method and resource in cell lines and in mice for mass spectrometry-based identification of interactors of the proteasome, a multi-protein complex with a central role in protein turnover in almost all tissues and cell types. The method presented, including the experimental workflow and analysis pipeline, as well as the several lines of validation provided throughout, is convincing. Given the growing interest in protein aggregation and targeted protein degradation modalities, this work will be of interest to a broad spectrum of basic cell biologists and translational researchers.

   Reviewed by eLife, preLights

8. The title and authors for this article are not available from our external data provider yet:
   10.48550/arxiv.2302.14157v2

9. Autoacetylation-mediated phase separation of TIP60 is critical for its functions

   This article has 3 authors:

   1. Shraddha Dubey
   2. Himanshu Gupta
   3. Ashish Gupta

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This is a valuable study on K187 acetylation of the nuclear protein, TIP60, required for its phase separation and function. The evidence supporting the primary conclusion is incomplete and warrants more scrutiny.

   Reviewed by eLife

10. Multiple objects evoke fluctuating responses in several regions of the visual pathway

    This article has 12 authors:

    1. Meredith N Schmehl
    2. Valeria C Caruso
    3. Yunran Chen
    4. Na Young Jun
    5. Shawn M Willett
    6. Jeff T Mohl
    7. Douglas A Ruff
    8. Marlene Cohen
    9. Akinori F Ebihara
    10. Winrich A Freiwald
    11. Surya T Tokdar
    12. Jennifer M Groh

    This article has been curated by 1 group:

    • Curated by eLife

      eLife assessment

      This important study adds to the growing body of evidence that neural responses fluctuate in time to alternatively represent one among multiple concurrent stimuli and that these fluctuations seize when objects fuse into one perceived object. The present study provides solid evidence from multiple brain areas and stimuli types to support this hypothesis. Overall, the study illustrates how the brain can use time dimension and synchrony to either parse or integrate stimuli into a coherent representation.

    Reviewed by eLife