eLife

Latest preprint reviews

1. Reduced mitochondrial transcription sensitizes acute myeloid leukemia cells to BCL-2 inhibition

   This article has 11 authors:

   1. Laleh S Arabanian
   2. Jenni Adamsson
   3. Anke Unger
   4. Raffaella Di Lucrezia
   5. Tim Bergbrede
   6. Arghavan Ashouri
   7. Erik Larsson
   8. Peter Nussbaumer
   9. Bert M Klebl
   10. Lars Palmqvist
   11. Claes M Gustafsson

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This solid study assesses a mitochondrial polymerase inhibitor in combination with the BCL-2 inhibitor venetoclax, with the aim to increase the elimination of acute myeloid leukemia. It provides valuable findings of combinatorial efficacy using preclinical models in vitro and in vivo, confirming the overall importance of targeting oxidative phosphorylation to overcome venetoclax resistance in acute myeloid leukemia, and could be strengthened through mechanistic studies demonstrating on target effects and pharmacodynamic efficacy in vivo. The study is of interest to hematologists because it addresses a key biomedical issue in acute myeloid leukemia (venetoclax resistance) and provides data regarding the safety and activity of a novel inhibitor of the mitochondrial polymerase in combination with venetoclax.

   Reviewed by eLife

2. We couldn't get details of this article at this time:
   10.1101/2023.08.22.554368

3. We couldn't get details of this article at this time:
   10.1101/2023.05.30.542747

4. We couldn't get details of this article at this time:
   10.1101/2024.04.10.588911

5. We couldn't get details of this article at this time:
   10.1101/2024.03.25.586546

6. We couldn't get details of this article at this time:
   10.1101/2024.04.18.590147

7. We couldn't get details of this article at this time:
   10.1101/2023.12.20.572676

8. Widespread Horizontal Gene Transfer Among Animal Viruses

   This article has 7 authors:

   1. Christopher B. Buck
   2. Nicole Welch
   3. Anna K. Belford
   4. Arvind Varsani
   5. Diana V. Pastrana
   6. Michael J. Tisza
   7. Gabriel J. Starrett

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study is a computational analysis using publicly available deep sequencing datasets and the findings support the models that propose widespread gene transfer amongst DNA viruses. The evidence supporting the claims of the authors is solid, but reproducing the analysis based only on the information as presented in the Materials and Methods would be difficult as the data are currently presented. A Flow chart that details the process would help. This is an almost entirely computational study without experimental evidence but one that has the potential to become a fundamental resource for virus hunters - an activity of increasing importance.

   Reviewed by eLife

9. We couldn't get details of this article at this time:
   10.1101/2022.09.26.509455

10. We couldn't get details of this article at this time:
    10.1101/2024.04.02.587731